A simple and mild approach to alpha-hydroxyglycine synthesis and derivatization that is compatible with commonly used amino acid protecting groups. Congrats to coauthors Pooja Solanke, Debolina Sarkar, and Pranab Saha! www.biorxiv.org/content/10.6...

Our red-shifted aromatic cation manuscript is now out in @jacs.acspublications.org! Lots of data to unpick, including mechanistic photochem, protein labelling, sensing in live cells, and chemical proteomics. Congrats to coauthors Pranab, Pooja, Sanwayee, and Vishal! pubs.acs.org/doi/10.1021/...

Designer Aromatic Cations for Photoinduced Protein Ligation, Imaging, and Intracellular Labeling at Extended Wavelengths

Photoinduced protein labeling strategies have become essential tools in chemical biology, but most strategies require high-energy wavelengths of light as input to drive reactivity. Recently, we report...

pubs.acs.org

Check out the final version of our work on photocatalytic protein ligation in @jacs.acspublications.org. Using a matched pair of simple aromatic cations, we show rapid labelling at the peptide, protein, and intracellular level. Great work by Vishal, Hieu, and Sam! pubs.acs.org/doi/abs/10.1...

Cation–Cation Photosensitization for Protein Ligation and Intracellular Catalysis

We report here a photosensitized strategy for protein labeling in which N-substituted pyridinium salts are activated using a 2,4-diaryl-N-methyl quinolinium scaffold. Structure–reactivity relationship...

pubs.acs.org

Check out our latest preprint in @biorxivpreprint.bsky.social. Like charges usually repel each other, but here we show the right pair of aromatic cations can actually be sensitize each other for protein labelling, even inside a cell. Congrats to Vishal Hieu and Sam! www.biorxiv.org/content/10.1...

Check out our 2nd preprint of the week! It was a privilege to collaborate with @gustafsonlabsbu.bsky.social to demonstrate that our recently developed radical photocages enable quick and simple photo-induced trifluoromethylation of small molecule organics and API's. chemrxiv.org/engage/chemr...

Facile Trifluoromethylation of Arenes and Heterocycles via a Bench Stable Photocaged Trifluoromethylation Reagent

Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic, aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid a...

chemrxiv.org

Check out our latests work in collaboration with @taylorlab-chembio.bsky.social! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected rapid trifluoromethylation of diverse aromatics, including several APIs. chemrxiv.org/engage/chemr...

Happy to share our preprint in @biorxivpreprint.bsky.social on designed aromatic cations for photochemical protein ligation. We show intracellular labelling w/ green light, wash-free imaging, and mechanistic insights. Congrats to Pranab, Pooja, Sanwaye, and Vishal! www.biorxiv.org/content/10.1...

Designer Aromatic Cations for Photo-Induced Protein Ligation, Imaging, and Intracellular Labelling at Extended Wavelengths

Photo-induced protein labelling strategies have become essential tools in chemical biology, but most strategies require high energy wavelengths of light as input to drive reactivity. Recently, we repo...

biorxiv.org

Hey Organic Asst Profs coming up for tenure (and your senior colleagues) — it is nomination season for the ACS DOC Young Academic Investigators Symposium. Deadline is Feb. 6, 2025. The website has last year’s date 😳 but the other info is right. #ChemSky www.organicdivision.org/meetingsuppo...

I have an AstraZeneca-funded PhD position available (4 years), based in my lab (School of Chemistry, University of Nottingham); start date Oct 2025! Traceless Chemoenzymatic Peptide Synthesis Application deadline: 6 Jan 2025. Get in touch!!! www.findaphd.com/phds/project...

Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham on FindAPhD.com

PhD Project - Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham, listed on FindAPhD.com

findaphd.com

Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1: go.bsky.app/3P5i7nJ V2: go.bsky.app/Cr4ej7

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

What better way to open our acct on bsky than by announcing a new paper! Check out the final version of our pyridinium-ylide alkylation approach for accessing highly bespoke #chembio pyridinium probes in JOC/@amerchemsociety.bsky.social! Congrats to authors Ash and Ben on the great work!