Our new review on epithelial barrier homeostasis has been published in Trends in Cell Biology(www.cell.com/trends/cell-...)! Please use the following link for free access until May 1: authors.elsevier.com/a/1mlnq3QxxT...

Epithelial barrier homeostasis

Epithelia cover the body’s surface to form a barrier that segregates the internal body from the external environment. Tight junctions (TJs) seal the paracellular space and are crucial for the formatio...

cell.com

Please comment on this! The complexity of living systems cannot be fully recapitulated by in vitro or computational approaches alone. While advances in non-animal model technologies offer complementary tools, they lack the full physiological and developmental context of a living organism.

Needhi Bhalla 💅🏽@needhibhalla.bsky.social · last yr.

🧪 After the workshop on 7/7, the FDA and NIH are asking for public comments on implementing novel methodologies and other strategies to reduce the use of animal testing by 7/14: www.fda.gov/news-events/...

New preprint from the lab! We show that epithelial cells lacking ZO-1/ZO-2, the key scaffolding proteins of tight junctions, are eliminated when surrounded by normal cells. (1/n) www.biorxiv.org/content/10.1...

Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis

Epithelia cover the body and form a barrier to segregate the internal body from the external environment. Epithelial tissues contact the external environment and are exposed to various stresses that a...

biorxiv.org