When imaging is normal, but biology is not: Aligning diagnostics of pain states with nociceptive biology

Pain is the leading reason people seek medical care. Yet, the diagnosis of acute and chronic pain states remains tied to a structural paradigm that equates real disease with visible anatomical…

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Exploring exercise prescription parameters for pregnancy-related pelvic girdle pain: A systematic review and meta-analysis of effects on pain and function

Exercise is recommended for pregnancy-related pelvic girdle pain (PGP), while consensus on specific prescription parameters remains uncertain. We conducted a systematic review and meta-analysis of…

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Intravenous ketamine for complex regional pain syndrome: Pain outcomes and predictors of response. A systematic review and meta‑analysis

Intravenous ketamine is used for complex regional pain syndrome (CRPS), but variable response and uncertain durability limit patient selection. This systematic review evaluated reported predictors of…

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Neuroimaging correlates of pain in Parkinson’s disease: A systematic review of structural and resting-state fMRI studies

Chronic pain is a common non-motor symptom in Parkinson’s disease (PD), but its central neural mechanisms are not fully understood. Structural and resting-state functional MRI offer non-invasive…

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2027 Call for Symposia | USASP

Representing scientists nationwide who collaboratively research, diagnose, and treat pain in the United States.

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When one plus one doesn’t equal two: A commentary on strengthening the care of young people experiencing comorbid chronic pain and mental health conditions

Chronic pain and mental health conditions are often conceptualised and communicated to young people, and others, as totally separate entities. Taken together however, ‘one plus one does not equal…

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Patients’ pain experience in claudication: Biopsychosocial correlates of frequency, intensity, sleep interference, and chronic pain

Pain is the hallmark symptom of claudication, the early stage of peripheral artery disease (PAD), yet its relationship with psychological distress remains unclear. We described pain patterns and…

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What factors influence ratings of Global Perceived Effect by individuals with low back pain and physiotherapists?

The Global Perceived Effect (GPE) scale is widely used to evaluate perceived improvement in individuals with low back pain (LBP). However, factors that influence GPE ratings by patients and…

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Psychometric evaluation of interpretation bias measures for pain

Negative interpretation bias, the tendency to interpret ambiguous information in a threatening way, is thought to play an important role in the experience and maintenance of chronic pain. However,…

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How does caregiver protectiveness change between pain states and across different contexts? A vignette study of expected responses to pain

Greater caregiver protectiveness is often associated with poorer outcomes in children and adolescents with pain. However, there is a lack of understanding about the specific contexts of where…

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The endometriosis pain course: Exploring predictors of clinical response to an internet-delivered psychological pain management program for endometriosis

Emerging research indicates the potential of psychological pain management programs to address disability and distress associated with endometriosis-related pain. Understanding the characteristics of…

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A psychometric assessment of a new Spanish version of the pain self efficacy questionnaire (PSEQ) adapted for Spanish-speaking Mexican Americans

Chronic pain affects millions of people in the United States (U.S.), with Latinx individuals facing higher risks due to chronic illness, manual labor jobs, and limited access to healthcare and…

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“A lot of bureaucracy”: Structural barriers to prescription opioids in cancer pain management

Well-intentioned policies to reduce opioid prescribing can conflict with efforts to manage advanced cancer pain, resulting in structural barriers to opioid pain management that complicate the…

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Effect of self-management interventions on high impact chronic pain prevalence

Among persons with High Impact Chronic Pain (HICP), we assessed the impact of cognitive behaviorally-based self-management interventions on sustained HICP and on favorable chronic pain outcomes (mild…

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Structural network dysfunction and aberrant SC-FC coupling correlate with central post-stroke pain of thalamic origin

Central post-stroke pain (CPSP) of thalamic origin is one of the most frequent subtypes in all kinds of CPSP, and often be refractory to treatments and affect the long-term prognosis of thalamic…

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A critical role for α7 nicotinic acetylcholine receptor signaling in myeloid lineage cells in chronic neuropathic and inflammatory pain responses

Neuroinflammation influences the development of chronic pain, an increasingly prevalent condition impacting the lives of many worldwide. Given the challenges of managing chronic pain, it is essential…

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Illuminating ongoing pain in mice with novel bioluminescent imaging

Objectively measuring pain in laboratory animals is essential for pain research and analgesic development. Despite the development of various behavioral tests to measure evoked pain in animal models,…

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Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner

Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory and immune mechanisms are activated following TSE, play a role in the transition from acute…

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New strategy for treating visceral pain: Enhancing opioid antinociception by Sigma-1 receptor inhibition

Visceral pain remains a major clinical challenge, often resistant to conventional analgesics. Sigma-1 receptor (σ1R) antagonists enhance opioid antinociception in somatic and neuropathic pain, yet…

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The association between diverse dietary quality measures and the presence of acute or chronic pain in the UK Biobank

Chronic pain affects approximately 20% of adults worldwide and is a leading cause of disability. Emerging evidence suggest that nutrition may influence pain perception. However, the association…

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Treating pain and trauma: A systematic review of non-randomized studies of psychotherapeutic approaches

The co-occurrence of chronic pain and trauma symptoms is prevalent; thus treatment approaches that address both are required. This systematic review of non-randomized studies aims to describe…

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https://www.jpain.org/article/S1526-5900(26)00161-6/fulltext

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Temporal changes in mechanical pin prick sensitivity following high frequency induced sensitisation of central nociceptive pathways: A test re-test reliability study

High-frequency stimulation (HFS) is a human surrogate model of secondary hyperalgesia and a key experimental tool for understanding the mechanisms and modulation of central nociceptive pathways. An…

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Structural and individualized racism drives racial disparities in chronic low back pain: A cross-sectional serial mediation analysis

This cross-sectional study examined whether individualized racism, as measured by experiences of discrimination, internalized stigma of chronic pain, and perceived injustice, as well as structural…

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Bidirectional associations between daily sleep and pain severity in adults with rheumatoid arthritis: A daily diary and actigraphy study

Poor sleep and pain are common in rheumatoid arthritis (RA). This study sought to understand the temporal relationships between multidimensional sleep and pain in daily life among individuals with…

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Pre-surgical quantitative sensory testing and post-surgical pain among adolescents undergoing spinal fusion surgery: A longitudinal cohort study

Pediatric post-surgical pain is common and associated with diminished quality of life and significant medical costs. While quantitative sensory testing (QST) is a promising tool for predicting…

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Pain, pain catastrophizing, and autonomic nervous system dysfunction after traumatic injury: A prospective cohort study

Traumatic injuries from road traffic crashes are a major global health concern, resulting in significant physical, emotional, and social consequences, with pain being a frequent outcome. Chronic pain…

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Clinical features of central sensitization moderate the effect of repetitive transcranial magnetic stimulation in chronic low back pain

This secondary analysis of a randomized controlled trial investigated whether baseline clinical characteristics moderate the efficacy of repetitive transcranial magnetic stimulation (rTMS) and motor…

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Clinical features of central sensitization moderate the effect of repetitive transcranial magnetic stimulation in chronic low back pain

This secondary analysis of a randomized controlled trial investigated whether baseline clinical characteristics moderate the efficacy of repetitive transcranial magnetic stimulation (rTMS) and motor…

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Understanding pain and pain management patterns in construction workers: A latent class analysis of cross-sectional survey data

Understanding pain and pain management in the construction workforce is critical due to the physically demanding nature of their work. This study aimed to describe pain and quality of life among…

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