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Thorsten Müller

@thmllr.bsky.social

Biochemist fascinated by visualizing biological processes with the finest spatiotemporal detail; Understand the human immune system to guide novel approaches for combating viral infections and cancer; Postdoc at Cissé Lab / MPI-IE

12 Posts268 Follower705 Folgt
Ulrich Schwarz@ulrichschwarz.bsky.social · 8mo ago

Wow, researchers from our #SFB1129 are implicated in the Science 2024 Breakthrough of the Year, because they showed that HIV-capsids are flexible and go through nuclear pores. The latest paper on Lenacapavir-induced capsid damage just came out in @embojournal.org link.springer.com/article/10.1...

Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles - The EMBO Journal

Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...

link.springer.com

Science Magazine@science.org · 8mo ago

Science’s 2024 Breakthrough of the Year was lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. Learn more about last year's #BOTY on #WorldAIDSDay: https://scim.ag/48pk7zZ

Science’s 2024 Breakthrough of the Year was lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. The drug attaches to the lattice-like capsid proteins that shield the virus’s genetic material—a mechanism that could inspire other antivirals. Lenacapavir could help end the HIV/AIDS epidemic, but that will hinge on access for those who need it most.
Thorsten Müller@thmllr.bsky.social · 8mo ago

New paper out! How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so? Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects! open access: link.springer.com/article/10.1... read below

Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles - The EMBO Journal

Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...

link.springer.com