Excited to be presenting this work today at the 3DEM Gordon Research Seminar and later this week at the Gordon Research Conference. Looking forward to the discussions and feedback! www.grc.org/three-dimens...

Debnath Ghosal@debnathghosal.bsky.social · 2mo ago

New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀

New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀

A Novel Pilus System in Candidate Phyla Radiation Bacteria

The Candidate Phyla Radiation (CPR) represents a bacterial superphylum estimated to include between 15–50% of all bacterial species, yet CPR bacteria remain challenging to culture and have been primar...

biorxiv.org

Last week we had the CCeMMP Symposium 2025. Fantastic event with an outstanding line-up of speakers. There were 2 poster prizes and 1 oral presentation prize; thrilled that we did a clean sweep! Huge congratulations @tiltedscientist.bsky.social @somavallyd.bsky.social and @lucatroman.bsky.social

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

biorxiv.org

Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r... Thanks to all interviewees🎤

Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine

Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.

quantamagazine.org

We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally! lnkd.in/geXUApmK

We are excited to share our new study which talks about the unique anti-phage system. Please check out the article for more details. Thank you Debnath Ghosal and Sigal Ben Yehuda for this amazing opportunity. Thank you University of Melbourne and Pursuit team!

Debnath Ghosal@debnathghosal.bsky.social · 11mo ago

We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally! lnkd.in/geXUApmK

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/ Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic ⚔️🦠❄️🔬

An Asgard archaeon from a modern analog of ancient microbial mats https://www.biorxiv.org/content/10.1101/2025.07.22.663070v1

Excited to share that our work on a family of pore-forming proteins is now live in Science Advances! We show structural snapshots across the entire pore-forming pathway for a cholesterol-dependent cytolysin-like (CDCL) bicomponent system.

Fabulous collaboration with Steve Petrovski lab at La Trobe University. Amazing team that made this happen @tiltedscientist.bsky.social, JaysonRose, MiladReyhani, @unimelb, @FMDHS, @ccemmp-outreach.bsky.social.

Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator" www.nature.com/articles/s41...

I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5 Read more in Nature: www.nature.com/articles/s41... 🧪

Briggs Group@briggsgroup.bsky.social · last yr.

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social

Oh this is me, hello bsky!

cryoEM papers@cryoempapers.bsky.social · last yr.

Mutations in Gordonia amarae mycolic acid biosynthetic pathway confer resistance to Patescibacteria parasite Mycosynbacter amalyticus pubmed.ncbi.nlm.nih.gov/40038264/ #cryoEM