Tom Golde
@tomgolde.bsky.social
biophysics. post-doc @XavierTrepat lab barcelona. currently focused on intermediate filaments and epithelial tissues.
New paper in @natphys.nature.com! We uncovered a stress adapation mechanism where keratin intermediate filaments in stretched epithelia undergo a supracellular bundling transition that uncages the nucleus. www.nature.com/articles/s41... @ibecbarcelona.eu, @upc.edu @qmul.bsky.social
Coming back from the EMBO workshop "Structure and Function of the Cytoskeleton" in Paris. Happy to report that I won the best poster award for a story about intermediate filaments in a conference full of actin and microtubule people. Many thanks to the organizers for a great conference!
Spending the week at the EMBO workshop "Structure and Function of the Cytoskeleton" in Paris. I had a bit off a rough start since the airline insisted on checking in my poster roll at the gate and then loosing it somehow. Luckily, there are copy shops in the area so now I can focus on the science!
Tissue mechanics and synth morphogenesis folks, bump on this: Would you or someone in your lab be up for a video of a protocol you use getting recorded? The tips and tricks, the hard-to-explain-without-seeing-it-done? In the name of standardization and reproducibility in the field: get in touch! 🫀
Marija Matejčić (mateytch-itch)@marija-matejcic.bsky.social · 8mo agoI am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech
I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech
Today I'm traveling to Portimao, Portugal to play with the German Men's Masters National team at the World Beach Ultimate Championships 2025. Wish me luck. wbuc.sport
Check out the preprint of my main work in the lab of @xaviertrepat.bsky.social @IBECBarcelona. Many thanks to all the people involved!
Xavier Trepat@xaviertrepat.bsky.social · 11mo agoNew preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...
I'm proud to contributing to the development of the experimental system of this amazing study. I heard @onenimesa.bsky.social will do a whole thread soon. And maybe we have even more in the pipeline...
Xavier Trepat@xaviertrepat.bsky.social · last yr.🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu www.biorxiv.org/content/10.1...
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering
What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations? I'm @juliaeckert.bsky.social. Let's explore some analysis software!
Xavier Trepat@xaviertrepat.bsky.social · last yr.New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs). www.nature.com/articles/s41... @ibecbarcelona.eu
Great stuff from our lab!
Xavier Trepat@xaviertrepat.bsky.social · 2y ago🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
Hello world! I wrote something about intermediate filaments and epithelial mechanics back on twitter. But you can also find it here :)
epithelial mechanics fan club@epimechfc.bsky.social · 3y agoBut what about intermediate filaments? This question is often in my head when I see a talk about cell mechanics focused on actin or microtubules. I am @tom_golde and today I will give you a short overview about the role of intermediate filaments (IF) in #EpithelialMechanics
