We are excited to announce that we are entering a strategic partnership with Bruker Fluorescence Microscopy to make whole-organ 3D imaging more accessible to the greater scientific community. (1/🧵)
Translucence Biosystems
@translucencebio.bsky.social
Leaders in next-generation 3D histology and AI-powered quantification for intact biological samples
Kit user highlight! The sample shown in the attached video was generated by Jenna McCloskey at The Ohio State University using a Translucence Biosystems Universal Tissue Clearing Kit. This video shows ΔFosB-positive cells across an intact rat brain hemisphere.
Coming up in less than two weeks: Join us at @ucberkeleyofficial.bsky.social for a Tissue Clearing Lunch ‘n’ Learn, presented in collaboration with the Cancer Research Laboratory’s Molecular Imaging Center.
This 3D visualization, captured on a #Zeiss lightsheet, shows Aquaporin-2 (AQP2) and smooth muscle actin (SMA) staining across an intact mouse kidney cleared with our Universal Tissue Clearing Kit!
This video highlights the power of tissue clearing and lightsheet imaging for providing deeper, spatially resolved insights in biological research.
Coming up next month: Join us at @ucberkeleyofficial.bsky.social for a Tissue Clearing Lunch ’n’ Learn, presented in collaboration with the Cancer Research Laboratory’s Molecular Imaging Center.
We love supporting and engaging with the next generation of scientists! Today at 1 PM, Director of Products and Business Development, Nathaniel Guansona, is speaking at University Lab Partners' Meet the Scientist series.
Tune in tomorrow for the Brainsight Breakthroughs webinar from ZEISS Microscopy featuring Melissa Cooper, PhD, and her recent work on astrocyte networks across the intact brain.
June is Alzheimer’s and Brain Awareness Month, a time to recognize the impact of Alzheimer’s disease and the importance of continued progress in brain research.
This video shows β-tubulin labeling across a cleared mouse embryo, highlighting cellular and cytoskeletal organization throughout the intact specimen.
cFos has been used for decades to map neuronal activity, however its expression is not a direct readout of neuronal activity, as cFos expression can be induced by broader signaling pathways, including cAMP-dependent pathways, neurotrophins, and other paracrine factors.
We are excited to attend the ASGCT 2026 Annual Meeting in #Boston this week, from May 11th to 15th. @asgct.bsky.social brings together the global cell and gene therapy community across scientific, translational, and regulatory areas to help advance these critical therapeutic areas.
Happy #FluorescenceFriday! This visualization shows a cleared whole-mouse spinal cord with left and right motor cortex neurons labeled in different fluorescent colors and traced continuously down the intact spinal cord in 3D.
On Monday, Translucence Biosystems attended the rally in Sacramento, CA, in support of SB 895, the California Science and Health Research Bond Act.
This 2D pan-through from a 3D light-sheet dataset shows a cleared mouse brain hemisphere stained for human IgG (red) and amyloid plaques (green).
Happy #FluorescenceFriday! Here is another look at how tissue clearing can support the evaluation of novel human antibody therapeutics for CNS-related diseases.
This visualization shows whole-brain tyrosine hydroxylase (TH) staining in a cleared mouse brain, revealing dopaminergic neuron cell bodies and projections at cellular resolution throughout the intact brain.
The data in this video highlights the power of tissue clearing for evaluating novel human antibody therapeutics for CNS-related disorders.
Happy #FluorescenceFriday! Today we are excited to share this video which shows a cleared mouse brain hemisphere following depletion of endogenous microglia and transplantation of human cells (magenta).
We had a great time at AD/PD™ 2026 in #Copenhagen, engaging with researchers driving advances in neurodegenerative disease research!
Today, we are presenting two posters at AD/PD™ 2026. Poster #3404 examines whole-brain measurement of plaques, microglia, α-synuclein, and tyrosine hydroxylase in AD and PD model mice using tissue clearing, light sheet imaging, and AI-powered quantification.
Today marks the start of AD/PD™ 2026 in #Copenhagen! We are excited to join the community this week to discuss new approaches for measuring CNS disease pathology and therapeutic distribution across intact brain tissue.
We are excited to announce our second poster that we will be presenting at AD/PD™ 2026!
We are excited to announce our first poster that we will be presenting at AD/PD™ 2026!
For the first Fluorescence Friday of the month, we want to take a moment to recognize Brain Awareness Month and celebrate the researchers and technologies helping us better understand the brain in health and disease.
Join CEO, Damian Wheeler, and Director of Products and Business Development, Nathaniel Guanzon, at #ADPD2026 as they present recent work applying our brain-wide measurement techniques to the evaluation of CNS therapeutics and disease pathology in intact tissue.
This dataset shows α-synuclein staining (green) in a cleared mouse brain following direct PFF injection. The video reveals the distribution of α-synuclein fibrils and cell bodies at cellular resolution across the intact brain.
This dataset shows alpha-synuclein staining in a cleared mouse brain following direct PFF injection. The video reveals the distribution of alpha-synuclein fibrils and nuclei at cellular resolution across the intact brain.
Your first look at our newest tissue clearing technology, TB.Clear™! Tissue clearing has transformed how we study intact biological systems, but many solvent-based methods (including widely used protocols like iDISCO+) can quench endogenous fluorescence.