Why do some children develop food allergies after liver transplantation? Study shows that pediatric LT recipients with LT-associated food allergy have heightened T-cell activation & elevated inflammatory cytokines, suggesting persistent immune activation. tinyurl.com/bdfs3wds

🦠 Good news for transplant recipients: RSV vaccination was safe and immunogenic in solid organ transplant recipients, inducing durable antibody and T-cell responses for up to 6 months. #TXPforAll #Transplantation #OpenAccess tinyurl.com/5ed4ccsz

Jang et al. report that a CNI+EVR regimen remains cost-effective after liver transplantation, supporting a balanced approach to reducing cancer, infection, and renal risks. #TXPforAll #Transplantation tinyurl.com/3yyum3fz

🩺 This 8-year study of vascularized composite allotransplantation (#VCA) recipients found an early decline in kidney function that largely stabilized over time. #Transplantation #Immunosuppression #TXPforALL tinyurl.com/45rtvra2

#TBT to this week's featured top downloaded paper from 2024:Prevention of Trafficking in Organs, Tissues, and Cells #Transplantation #Med tinyurl.com/ywcb4cba

This review explores how exposure to partner alloantigens induces FOXP3⁺ Tregs promote fertility & fetal–maternal tolerance, while in some individuals triggering alloantibodies linked to infertility & potentially increased organ transplant rejection. tinyurl.com/2kzb8f92

This study demonstrates the potential of temporal PGD classification for improving our understanding of how the dynamic nature of PGD affects survival. #LungTransplantation #TXPforALL tinyurl.com/3k4dpktf

What ethical safeguards are essential for organ donation after MAiD? This international review identifies three priorities: preserving voluntariness and informed consent, ensuring ethical donation practices, and protecting patient care relationships. tinyurl.com/yvt7pkmk

🔬 A biological solution for complex hernias? Donor rectus fascia allotransplantation restored abdominal wall integrity in patients where conventional mesh repair was not feasible. Early results are encouraging. #TXPforAll #transplantation #Surgery tinyurl.com/379bybek

#TBT to this week's featured top downloaded paper from 2024: Late Treatment With Autologous Expanded Regulatory T-cell Therapy After Alemtuzumab Induction Is Safe and Facilitates Immunosuppression Minimization in Living Donor Renal Transplantation tinyurl.com/yk577auu

Can #dapagliflozin (DAPA) improve outcomes in kidney transplant recipients with chronic allograft dysfunction? In this randomized placebo-controlled trial, DAPA did not preserve eGFR but reduced proteinuria, BP, and HbA1c with a favorable safety profile. tinyurl.com/2h5fmejr

🦠 Norovirus after #Transplantation remains a major clinical challenge. Which treatments actually work? This comprehensive scoping review of 58 studies finds promising signals—but highlights a striking lack of high-quality evidence. #TXPforAll #OpenAccess tinyurl.com/yuxdpmza

🫁 What if a lung transplant could "tell" us it's rejecting—before clinical signs appear? This study identifies distinct BAL macrophage signatures linked to rejection and poorer outcomes, opening avenues for early detection. tinyurl.com/25kmb2p6

New insights into transplant tolerance: this study identifies IL-35 as a key mediator of bidirectional immune regulation after HLA-identical kidney #transplantation. Exosome-delivered IL-35 may help sustain local graft tolerance. #Immunology #TXPforAll tinyurl.com/4rbhjxn4

#TBT to this week's featured top downloaded paper from 2024:Five-day Wearable Respiratory Support With a Novel Ambulatory Pulmonary Assist System in an Awake Ovine Model #Transplantation #Med tinyurl.com/2s3edfrw

🌍 A new global milestone: 173,727 solid organ transplants were performed in 2024—the highest number ever recorded. Growth was driven by increased deceased donation, particularly donation after circulatory death. #Transplantation #TXPforAll tinyurl.com/bddw5snt

From bench to bedside: this review highlights the latest advances in vascularized composite allotransplantation (VCA), including innovative immunotherapies and improving outcomes in uterus, face, and limb transplantation. tinyurl.com/5n798bv8

🩸 EPO does far more than make red blood cells. This review reveals its surprising role as an immune regulator—promoting transplant tolerance, calming inflammation, and reshaping immune cell function. #Transplantation #TXPforAll tinyurl.com/nb9mcjvb

📊 Body surface area- and kidney function-based valganciclovir dosing achieved target drug levels more often than weight-based dosing and was linked to faster CMV clearance. #TXPforALL #Transplantation tinyurl.com/24jpfz79

#TBT to this week's featured top downloaded paper from 2024:Elevation of Donor-derived Cell-free DNA Before Biopsy-proven Rejection in Kidney Transplant #Transplantation #Med tinyurl.com/3nyh9efb

Can engineered liver tissue help solve the donor shortage? A new oxygenation system using decellularized livers and artificial red blood cells improved the function and engraftment of hiPSC-derived liver tissue in mice. #TXPforALL #Transplantation tinyurl.com/mv9f8he4

🫁 In a mouse model, delayed treatment reduced chronic airway injury and inflammation, but earlier therapy provided greater protection. #LungTransplantation #CLAD #TXPforALL tinyurl.com/8p7tjfdz

Who benefits from SLKT? Analysis of US liver transplants shows: No survival benefit of SLKT when pretransplant eGFR ≥30. Clear survival benefit for patients with eGFR <30. The findings support stage-specific SLKT allocation and OPTN "Safety Net" policy. tinyurl.com/yzjjpr2r

In a study of 1,146 liver transplants with up to 10 years of follow-up by Pollmann et al., sex mismatch was not an independent predictor of survival after adjustment. Bottom line: donor sex alone should not limit donor selection. 🫀➡️🫁 tinyurl.com/45s85xf4

#TBT to this week's featured top downloaded paper from 2024:Mechanistic Understanding of EBV+Lymphoproliferative Disease Development After Transplantation #Transplantation #Med tinyurl.com/yvns794d

French nationwide study: High-Emergency Lung Transplantation (HELT) was linked to higher postoperative morbidity but not higher 1-year mortality after adjustment. Findings support HELT as an effective strategy for the sickest patients. tinyurl.com/2w38ubkc

New study shows remarkable growth in U.S. Good Samaritan kidney donation. From 2000–2024, annual donations increased from 17 to 439. Voucher-based nondirected donation grew from 2 donors in 2015 to 314 in 2024, representing 72% of Good Samaritan donations. tinyurl.com/msd6wbxb

After liver transplantation, adding everolimus to CNI therapy: ✅ Reduced cancer risk ⚠️ Increased infection risk 💰 Remained highly cost-effective When accounting for cancer, infection, and kidney dysfunction, EVR-based therapy delivered good value. tinyurl.com/ye93kk9p

Prior Roux-en-Y gastric bypass may increase the risk of malabsorption, sarcopenia, recurrent steatohepatitis, and graft loss after liver transplantation. These cases highlight the importance of careful nutritional assessment and long-term monitoring. tinyurl.com/bpn6jke3

#TBT to this week's featured top downloaded paper from 2024: Cancer Surveillance in Solid Organ Transplant Recipients With a Pretransplant History of Malignancy: Multidisciplinary Collaborative Expert Opinion #Transplantation #Med tinyurl.com/3mw579zt