Honored and humbled to have received the UNC Charlotte Klein College of Science Excellence in Research Award (Advanced Scholar) for our work on Proteostasis and the Hsp70 chaperone code 🔥
Andy Truman PhD
@trumanlab.bsky.social
Group leader, Charlotte Group for Proteostasis Research | Associate Chair for Research in Biological Sciences at UNC Charlotte | Interested in the role of Hsp70 PTMs in yeast and mammalian cells | www.trumanlab.org
Voilà enfin le papier dont je vous parlais depuis un petit temps. Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co-chaperones such as JDPs and NEF...
febs.onlinelibrary.wiley.com
New article about our research: science.charlotte.edu/2026/02/23/u...
UNC Charlotte Truman Lab publishes new insights into cellular heat shock response in Nature Communications - Klein College of Science
A new study from the Truman Lab has been published in Nature Communications, offering a deeper understanding of how cells respond to heat-induced stress.
science.charlotte.edu
We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org
Cancer Research Laboratory | Trumanlab | UNC Charlotte | United States
The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...
trumanlab.org
Super excited to share our latest work on the Hsp70 chaperone code "Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response" out now in Nature Communications: www.nature.com/articles/s41...
Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response - Nature Communications
Cells must sense heat quickly to protect their proteins and membranes. Here, the authors show that membrane stretch detected by the membrane sensor Mid2 promotes rapid phosphorylation of the Hsp70 cha...
nature.com
Colleague Shan Yan doing a great job highlighting our Genome research at the NC Biotech Summit at the newly opened Pearl campus in Charlotte!
Had a wonderful time visiting Marquette University Biological Sciences to share our recent work on the Hsp70 Chaperone Code! Thanks to Emily Sontag for inviting me! Such a beautiful campus and loved talking with the students and faculty about the exciting research going on 🔥🔥🔥#hsp70
This study, led by Megan Mitchem & Ashley Choi at the Truman Lab (@trumanlab.bsky.social), provides a resource for dissecting the functional landscape of Cdc37 post-translational regulation & highlights new regulatory sites w/potential relevance to chaperone-kinase network dysregulation in disease.
ASBMB Journals@asbmbjournals.bsky.social · 11mo agoNew in JBC press: "Dissecting the Cdc37 Co-chaperone Code: Functional Roles in Chaperone-Mediated Stress Adaptation." Learn more: www.jbc.org/article/...
Excited to share our new work "Dissecting the Cdc37 Co-chaperone Code: Functional Roles in Chaperone-Mediated Stress Adaptation" in press at the Journal of Biological Chemistry www.jbc.org/article/S002...
Dissecting the Cdc37 Co-chaperone Code: Functional Roles in Chaperone-Mediated Stress Adaptation
Cdc37 is a kinase-specific co-chaperone that scaffolds protein kinase clients to the Hsp90 chaperone system. Although phosphorylation at residues S14 and S17 is known to regulate Cdc37 function, the b...
jbc.org
Friday was the 10th anniversary of setting up my lab! My amazing team hosted a party-the showstopper was the video they made that contained messages from all my previous students, mentors and collaborators!Finished the day by failing Beat the bomb in Charlotte!
@ronbeavis.bsky.social Hi Ron, I teach a graduate course on cell signaling and each year do a couple of classes on PTMs. I love showing the students how to use the gpmdb for their studies but can’t access it anymore from the US. Do you offer paid access/educational discount for those in the US?
Excited to begin my new role as Associate Chair for Research in the Department of Biological Sciences at UNC Charlotte 🔥🔥
Great time celebrating the achievements of the lab at Fahrenheit restaurant-graduations, proposal defenses, papers and grants! So grateful for the hard work and energy my team bring!
A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀
Classic NIH shenanigans-R03 scores: A0: ND A1: 26 (need 25 to be funded) Revised A0: 40 😭
On adaptation to a mesophilic environment and the chaperone network in Archaea Hopla il est là et je ferais une petite explication de ce que j'ai cherché à comprendre dedans. Mais ça parle de chaperonnes et d'archées et de relations entre évolution et HSP70. www.biorxiv.org/content/10.1...
On adaptation to a mesophilic environment and the chaperone network in Archaea
A prevailing hypothesis for the emergence of life on Earth holds that it might have originated in hydrothermal vents, where the environmental conditions, although physically and chemically extreme (ac...
biorxiv.org
Mathieu M.J.E. Rebeaud@chercheurjuteux.com · last yr.Hop article envoyé à Biorxiv. Je suis un peu sorti de ma zone de confort pour celui-ci quand même.
Grateful to have been awarded the first UNC Charlotte Klein College of Science award for Research and Scholarship (KNOBEL) 🔥🔥🔥
Proud of undergraduate students Shreya Patel and Erica Flores on doing a great job presenting their work at the University of North Carolina at Charlotte Undergraduate Research Symposium! Incredible findings on the Hsp70 and BiP PTM code!
The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net
Hi everybody! The Yeast journal is finally on Bluesky! Follow us to keep updated on the latest research articles, reviews and special issues on #Yeast biology and more! 🙂
The celebration of UNC Charlotte reaching R1 status was such a positive and inspiring event! Go Niners 🔥🔥🔥
Our inaugural Rising Stars in Proteostasis seminar was a roaring success! Thanks to Dr. Ian Guldner for visiting from Stanford University and giving an amazing talk on the decline of proteostasis in aging 🔥🔥🔥 #proteostasis #charlotte
Access to the GPM database removed for US researchers 😬
I can no longer access pubmed or eracommons WTH is going on????
In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n www.nature.com/articles/s41...
Hi everyone! New here 😄 excited to connect and learn about/share cool research in aquatic microbial ecology, or just science in general! Here's our lab photo to kick-start another year! #newPI
