@tsaiwenchen.bsky.social
We developed a new approach for mapping absolute membrane voltage, based on dynamic photocycle control in Voltron2. www.biorxiv.org/content/10.6... Here's my favorite example: human iPSC colonies break into electrical domains as they begin to differentiate.
Proud of this work from David Wong-Campos (@wongcamposd.bsky.social), Pojeong Park, Byung Hun Lee (@bhlee1117.bsky.social), and team: www.nature.com/articles/s41...
Voltage dynamics of cortical dendrites in vivo - Nature Neuroscience
Simultaneous voltage imaging of soma and dendrites in layer 2/3 cortical neurons in live mice reveals rich dynamics of spike back-propagation, with amplitude shaped by spiking history, dendrite locati...
nature.com
Mapping the Sense of Smell, Molecule by Molecule 🧠 🧪🧬 #AcademicSky #higherEd www.mcb.harvard.edu/department/n... @dulaclab.bsky.social @harvardbrainsci.bsky.social @yohisogai.bsky.social @zhuanglab.bsky.social @harvardbrainsci.bsky.social @hhmi-science.bsky.social @alleninstitute.org
Mapping the Sense of Smell, Molecule by Molecule - Harvard University - Department of Molecular & Cellular Biology
A new study from the lab of Catherine Dulac, the Xander University Professor of Molecular and Cellular Biology at Harvard, in collaboration with Xiawei Zhuang of Harvard’s Departments […]
mcb.harvard.edu
Designer indicators for two-photon recording of subthreshold voltage dynamics https://www.biorxiv.org/content/10.64898/2026.04.08.717226v1
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...
SCN2A is a top risk gene for autism. But how does losing one copy of it affect dendritic function during flexible decision-making? 🧬🐭🧠🧪 Our study in preprint @biorxivpreprint: www.biorxiv.org/content/10.1... Supported by a @simonsfoundation.org SFARI Pilot Award 🙌 #SCN2A #cureSCN2A
My debut on BlueSky! Here’s how we harvest the firing of neurons to see them better in the living brain! 👇 www.nature.com/articles/s41... Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
Imaging neuronal voltage beyond the scattering limit - Nature Methods
ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populati...
nature.com
Nature Methods@natmethods.nature.com · last yr.ALI, a method for analyzing voltage imaging data, allows resolving the activity of single neurons in densely labeled populations in scattering conditions. www.nature.com/articles/s41...
It's been done for a while, accepted almost a year ago, but I'm happy to share that my first analysis of the MICrONs cubic mm dataset is online! nature.com/articles/s41...
Inhibitory specificity from a connectomic census of mouse visual cortex - Nature
Using volumetric electron microscopy, the authors map and analyze the structure of cortical inhibition with synaptic resolution across a column of visual cortex.
nature.com
I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰 🔗 www.nature.com/articles/s41...
Connectome-driven neural inventory of a complete visual system - Nature
A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.
nature.com
