I am honored to share that I have been promoted to Associate Professor with tenure. It has been a privilege to build a lab at Duke, to ask questions that genuinely excite me, and to work alongside talented and curious trainees and colleagues. More than anything, I am excited for what comes next. 🎉

Now online @nature.com! Want to change the consequences of receptor activation? Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥 So many new possibilities! 🧪🧠🟦 www.nature.com/articles/s41... 🧵👇

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature

Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

nature.com

The lab had an excellent time at the annual Duke Pharmacology & Cancer Bio retreat! Katherine gave a great talk, and she and Matt each won a department award to recognize success in obtaining a fellowship and an impactful publication, respectively. 🎉

Our preprint “GPCR endocytosis rewires neuronal gene expression and cellular architecture” is now live on bioRxiv. 🔗 doi.org/10.1101/2025... We uncover how GPCR trafficking shapes protein content and neuronal structure. Congratulations to our team members, Katherine Hall and Matt Klauer! A short🧵

📣 We are looking for a full-time research technician. This is a great opportunity for recent grads seeking additional hands-on experience before grad or med school. Join our team in exploring GPCR signaling and pharmacology at @dukemedschool.bsky.social Description: careers.duke.edu/job/Durham-R...

Great science and stunning views of the Niagara Falls at the GRK and arrestin @faseborg.bsky.social meeting. Thanks to @sudarrajagopal.bsky.social @calebirolab.bsky.social @joann-trejo.bsky.social and Irene Coin for organizing an excellent conference and for the invitation. #GKASRC

Congrats to our grad student Peter on successfully passing his prelim 🎉

Celebrating all wins- big and small. Marking our new grant with a great evening of bowling and bonding with our collaborators, the Walsh lab at UNC!

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening www.nature.com/articles/s41...

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology

This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

nature.com

Check out our later take on GPCR signaling in space and time and the toolbox of chemogenetic and chemical biology approaches to explore this cool phenomenon ⬇️. I had a blast working with my colleagues @MiriamStoeber, @cyclic_Andreas and Braden Lobingier. doi.org/10.1038/s415...

Chemical biology approaches to resolve the subcellular GPCR signaling landscape - Nature Chemical Biology

This Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of sign...

doi.org

Congratulations to Malarie on passing her prelim exam with flying colors 🎉🍾

Celebrating some exciting wins in the Tlab lately (grants awarded, papers accepted, new jobs, and experiments finally behaving) with 🍹🌮

🎉 Thrilled to announce we have received the NoA for our new NIMH R01! Excited for the discoveries ahead and grateful to the NIH for the support.

Huge congratulations to Dr. Matt Klauer on a terrific PhD defense 🎊! Matt excelled consistently throughout his candidacy and has started a number of exciting new directions in the lab 🔬. We wish him all the best as he embarks on the next chapters of his scientific journey 👨🏻‍🎓🍾🎉

Excited to share the publication of our latest #NIH funded work led by Matt Klauer where we determine how #GPCRs shape the translational landscape of cells: www.pnas.org/doi/10.1073/...

Some much-needed good news 🎉: I am honored to receive the ASPET Molecular Pharmacology Division Early Career Award. Big thanks to Mikel Garcia-Marcos for the nomination. I am very grateful for the support and recognition by my colleagues at #ASPET and beyond. ow.ly/nYiB50UNQLF

I am thrilled to congratulate Katherine Hall in the lab on being awarded an @americanheart.bsky.social predoctoral fellowship 🎉! Way to go!!

My dept (Pharmacology and Cancer Biology) is conducting a joint search with the Department of Integrative Immunobiology at Duke for a tenure-track Assistant Professor in the area of tumor immunology. Join our collaborative and vibrant scientific community. academicjobsonline.org/ajo/jobs/29186

👋 Excited to join the @bsky.app community! We are a cell biology lab interested in how drugs shape gene expression, with particular focus on GPCR signaling and regulation.