Huge congratulations to Daniel Rodrigues who led this study on trying to understand how BAS-2 binds to HDAC6. www.nature.com/articles/s41... An amazing collaboration with David Christianson and Juana Stollmaier who provided key structural insights through X-ray crystallography.

Congratulations to Dr. Eoin O'Cearbhaill. www.ucd.ie/innovation/n...

2026 NovaUCD Innovation Award

ucd.ie

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

science.org

A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki... It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/.... The goal is to understand network-based signalling.

Congratulations to the recipients of the Nobel Prize in Physiology or Medicine 2025 - Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" including the identification of regulatory T cells #NobelPrize #Tregs @nobelprize.bsky.social 🧪🔬🏆

🏆 Congratulations to our Director, Prof @dchenshall.bsky.social, on receiving the ILAE Ambassador for Epilepsy Award at the 36th International Epilepsy Congress in Lisbon—recognising his global impact on epilepsy research. @ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social

Cells swapping their #mitochondria - this sounded like science fiction 🧪 when the first studies started coming out! But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!

Cells are swapping their mitochondria. What does this mean for our health?

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

nature.com

Huge congratulations to Andy on the publication of his PhD work! This was a massive team effort, thanks to the lab for helping out & collaborators: Ingmar Schoen, Emmar Kerr @mariemcilroy.bsky.social Link here: www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications

Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...

nature.com

Very excited about the first Irish Multiple Myeloma Meeting being held this September 12th!! Mark the calendars it should be a great meeting.

ApoList – April 2025 – Articles on apoptosis and cell death With several articles about how mRNA splicing problems cause necroptosis by zDNA, and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis) celldeath.wordpress.com/2025/05/06/a...

ApoList – April 2025

Bcl-2 family proteins Structural basis of BAK sequestration by MCL-1 in apoptosis Shagun Srivastava, Giridhar Sekar, Adedolapo Ojoawo, Anup Aggarwal, Elisabeth Ferreira, Emiko Uchikawa, Meek Yang, …

celldeath.wordpress.com

Congratulations to Dr. Ludovica Di Martino @rcsi.bsky.social for receiving the Prof. John Fitzpatrick award at the IACR meeting for her presentation on Multiple Myeloma. We celebrated with delicious Italian treats! Thanks to collaborator Prof. Siobhan Glavey @Beaumont RCSI Cancer Centre.

www.nature.com/articles/s41...

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

nature.com

Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪 "Embracing #cancer complexity: Hallmarks of systemic disease" Swanton et al, 2024 www.sciencedirect.com/science/arti... @charlesswanton.bsky.social @cancerresearchuk.org @cp-cell.bsky.social

Cell - a Cell Press journal@cp-cell.bsky.social · 2y ago

As we wrap up our year-long celebration of Cell’s 50th anniversary, we present “Cell Line: 2014–2024,” a timeline highlighting a set of exceptional scientific works—both landmark papers and essential reviews—published in the journal. www.cell.com/action/showP...

Huge congratulations to the newly minted Dr. Andy Roe on his viva 🎉!! Thanks so much to examiners @crismunozp.bsky.social and Dr. Niamh Connolly (not on Blue sky!) and the chair @christophertorrens.bsky.social @rcsi.bsky.social @rcsi-research.bsky.social. Looking forward to following your 💫 career.

An interesting paper just published in Nature on HDAC6 as a valine sensor: rdcu.be/d1waX

Human HDAC6 senses valine abundancy to regulate DNA damage

Nature - The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

rdcu.be

Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!

Ferroptosis—disease perils and therapeutic promise

Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment

science.org

Unfortunately, we have to postpone tomorrow’s webinar with Emma Farley. We will reschedule as soon as we can!

All-Ireland Chromatin Consortium@aicc-ireland.bsky.social · 2y ago

Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday! We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇