We’re excited to share a new article from @insitro.bsky.social (first author @zmccaw.bsky.social) in @ajhgnews.bsky.social, introducing a summary-statistic-based implementation of the COding-variant Allelic Series Test, COAST-SS: www.sciencedirect.com/science/arti...

A scalable framework for identifying allelic series from summary statistics

Genes where a dose-response relationship exists between functionality and phenotypic impact are appealing therapeutic targets, as the effects of pharm…

sciencedirect.com

We’re @ #ASHG to share our work that uses high-content phenotypic data, genetics & AI/ML to unblock new biology. @sominenihk.bsky.social presents work to identify a key gene as a clinical driver of #MASLD @twsoare.bsky.social presents on #AMD & how we use OCT scans to better predict disease risk

Today insitro announces an exciting new collaboration with insighteyehub.bsky.social at Moorfields Eye Hospital, London, through the development of a novel #AI foundation model to identify and to support #drugdiscovery. Learn more: www.businesswire.com/news/home/20...

Excited to share a new paper from @insitro.bsky.social (first author @zmccaw.bsky.social ) in @hggadvances.bsky.social vances.bsky.social on scrutinizing the practice of using a ratio trait (numerator / denominator) for GWAS. www.cell.com/hgg-advances...

Pitfalls in performing genome-wide association studies on ratio traits

Any variant associated with either numerator or denominator will associate with the ratio in GWAS of sufficient size. Associations with ratio traits are thus not specific to the ratio. Instead, we rec...

cell.com