Anesthesia is just like dreamless sleep, right? RIGHT? Cover story @anesthesiology.bsky.social this month - we developed an operating room protocol to promote dreaming during emergence from anesthesia... under the best conditions we found that **93%** of patients had experiences
Our (www.omarlab.org) latest paper -- effects of treatment with a single psychedelic dose on prefrontal cortex electrophysiology in a murine model of prenatal alcohol exposure! onlinelibrary.wiley.com/doi/10.1002/...
A Single Dose of a Psychedelic Drug Repairs Prefrontal Cortex Synaptic Physiology in a Mouse Model of Prenatal Alcohol Exposure
A single administration of the psychedelic drug 25CN-NBOH repairs synaptic physiology and intrinsic excitability of prefrontal cortex layer 5 (L5) pyramidal cells in adolescent mice following prenata...
onlinelibrary.wiley.com
Excited to share our latest publication -- psychedelic drugs can enhance synaptic connectivity of neurons not expressing 5-HT2ARs (but requiring 5-HT2AR expression in the input neurons -- lots in the supplementals too!) www.nature.com/articles/s41...
Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry
Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors
nature.com
Our latest manuscript (from www.omarlab.org) is now published and available online -- Long lasting enhancement in reversal learning after a single psychedelic dose pmc.ncbi.nlm.nih.gov/articles/PMC...
Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration
Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...
pmc.ncbi.nlm.nih.gov
Did you go to #GRCpsychedelics and not get soap? Don't worry, our themed soap will be ready in 2-3 weeks. Mouse brain toppers, rainbow swirl, dendrite+spine embed. Happy to send a free bar to ~10 people/ attendees. These are handmade by an amateur, so expect imperfections.
Somehow we got almost all the students and postdocs in one photo!! Until next time #GRCPsychedelics 🫡
#GRCPsychedelics is squad goals !! I learned so much, laughed even more, and slept even less Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.
A starter pack including all attendees (that I can find for now) Please let me know if I missed anyone! #GRCPsychedelics go.bsky.app/2ExXJcr
Awhile back we started a Slack group for psychedelic science. Researchers used it to organize meetups and panels at conferences. We discuss papers, including a lively discussion now of the Lu et al. preprint. DM @mikaelpalner.bsky.social or I if you work in academia and want to join
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
nature.com
Our latest preprint -- a single psychedelic dose induces a long-lasting improvement in reversal learning ability www.biorxiv.org/content/10.1...
Psychedelic enhancement of flexible learning weeks after a single dose
Psychedelic drugs have shown therapeutic potential for the treatment of multiple neuropsychiatric disorders chiefly by promoting long-lasting plasticity in the prefrontal cortex (PFC). A critical func...
biorxiv.org
Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬 www.biorxiv.org/content/10.1...
Psilocybin slows and reduces complexity of neural dynamics in medial prefrontal cortex. New paper with Ross Purple, Rahul Gupta, Matt Jones & Co.
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y agoShort- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1
Short- and long-term reconfiguration of rat prefrontal cortical networks following single doses of psilocybin https://www.biorxiv.org/content/10.1101/2024.12.10.627734v1
Our preprint on psychedelic control of prefrontal cortex pyramidal neurons! (from www.omarlab.org) www.biorxiv.org/content/10.1...
Cellular rules underlying psychedelic control of prefrontal pyramidal neurons
Classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2A receptors (5-HT2ARs). Here, we instead find that multiple classe...
biorxiv.org