We also made a website and python API to run starCAT with several other published gene program catalogs including a myeloid reference from @tymillerlab.bsky.social et al and a hematapoetic stem cell reference from @bloodandtime.bsky.social and Hojun Li

Case CCC/@uhcleveland.bsky.social researcher @tymillerlab.bsky.social targets myeloid cells in brain cancer www.uhhospitals.org/for-clinicia...

UH Seidman Researcher Parlaying Findings in Nature into More Effective Immunotherapy for Brain Tumors, Targeting Myeloid Cells

A major impediment to the successful use of immunotherapy in glioblastoma is the preponderance of a type of immune cell in the tumor, called myeloid cells, which can make up as much as 50% of all cell...

uhhospitals.org

Home cooked meals are the best. Grateful to have @vrishab_x's mother visit the lab from Seattle and cook us all authentic South Indian food for lunch today 😋❤️

Celebrating "UH100", the 100th brain tumor we've collected (in ~10 months!) & processed to learn more about these tumors & make patient organoids to test new therapies @uhreinstitute.bsky.social & @caseccc.bsky.social. Thanks to the patients, @staudtmd.bsky.social & Dr. Tiffany Hodges, & my lab!

Congratulations to @terminallycurious.bsky.social, Huang-lab MSTP student @CWRU, on her main thesis project!! Very happy we could help support her great story as our lab's first collaborative project. Turns out mechano-sensors are important in tumor-associated myeloid cells! @caseccc.bsky.social

Melissa Bonner@terminallycurious.bsky.social · last yr.

I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story! jitc.bmj.com/content/13/6...

I am excited to share my work which demonstrates that deletion of PIEZO1 surprisingly enhances cross-priming in tumor-associated myeloid cells. Thank you to @tymillerlab.bsky.social for your critical collaboration and @sitcancer.bsky.social for publishing my story! jitc.bmj.com/content/13/6...

Piezo1 deletion enhances cross-priming of CD8+ T cells by tumor-infiltrating CD11b+ dendritic cells

Background Tumor-associated myeloid cells (TAMCs) are an abundant, phenotypically plastic cell population that is critical for initiating a robust antitumor response. To properly combat cancer cells, ...

jitc.bmj.com

🚨Registrations now live! Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Register here: genelayinstitute.org/rtn/

A real privilege to be part of this meeting with so many leaders in the field that I admire. It is an inspiring group of passionate & dedicated physicians/scientists trying to tackle #GBM. Hoping that our collective efforts will lead to effective therapies for these patients. Thanks for the invite!

Banbury Center@cshlbanbury.bsky.social · last yr.

Thank you to participants of "Glioblastoma" for productive and invigorating discussions, with special thanks to organizers Drs. Melissa Bondy, Peter Dirks, and Bill Weiss. We are grateful to the @cshlnews.bsky.social - @northwellhealth.bsky.social Affiliation for support. Agenda: bit.ly/GBM-25

Our lab @caseccc.bsky.social, CWRU SOM, & University Hospitals is recruiting! We are looking for 2 talented immunotherapy postdocs eager to make an impact for brain tumor patients using cutting edge single-cell & spatial genomics & patient-tissue organoids - join us! Please share positions below:

Honored for our lab to be highlighted in the @caseccc.bsky.social annual report - I can't say enough great things about the environment and support for our new lab. 9 months in and so happy to be @CWRUSOM and @caseccc! A couple pictures in the lab that didn't make the report:

Case Comprehensive Cancer Center@caseccc.bsky.social · last yr.

From cutting-edge clinical trials to community outreach efforts, we’re making strides in the fight against cancer. Read the 2024 Case CCC Annual Report at www.flipsnack.com/caseccc/2024....

Celebrating two summer fellowships today with ice cream @ Mitchells! Congrats to Kaylie for being awarded the CanSUR fellowship for undergraduates and Medical student Alex Wang the @caseccc.bsky.social Medical Training Award! Both awards will support their work in the lab this summer 🔬

Was great to see friends and colleagues in London as part of the @braintumourcharity.bsky.social annual Scientific Advisory Board meeting! There are exciting things happening in brain tumor research around the world and honored to get to help guide it. Views were pretty good toon

New research uncovers four gene expression “programs” in immune cells that either suppress the immune system or make it more active — and could explain why brain cancer is often resistant to immunotherapy. @danafarbernews.bsky.social @nature.com

Why brain cancer is often resistant to immunotherapy

Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

broadinstitute.org

Proud to share our @nature.com paper, co-led by Chadi El Farran & Charles Couturier under mentorship of Brad Bernstein where we develop a new framework to understand immunomodulatory myeloid cells in #glioma & lay a foundation to develop more effective immunotherapies. www.nature.com/articles/s41...

Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature

A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...

nature.com

At #TRCCC @ejohnwherry.bsky.social gave an amazing talk about changing delivery of checkpoint blockade to increase efficacy, then ended with this slide, maybe his most important of the day. Share this information with your friends, family, neighbor!

Proud of my lab members who gave great talks today @ the #TRCCC conference!! Vrishab Kumar & Regan Murphy presented their computational projects this morning, and Shawn Ho & Alex Crane presented myeloid targeting projects this evening. CWRU SOM & @caseccc.bsky.social representing 💯

Annual @sitcancer.bsky.social crew picture at #TRCCC 2025 @immunegirl.bsky.social @ Michelle Williams and Sarah Gitto

The @tymillerlab.bsky.social rolling into #TRCCC 2025 and looking forward to 3 great days learning about the latest in immunotherapy!! #Roadtrip

Excited to be at @UCSF & @UCSFCancer to give the @UcsfPspg seminar today about our work and meet with friends and colleagues! Thanks to @LuRongze for the invite!

The Miller Lab birthday tradition continues at Mitchell's - happy birthday Namita!

I'll say it again, the best part of #SITC2024 is the people @NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁 Thanks for hosting @AkoyaBio!

The best thing about #SITC2024 is the people! @JennGuerriero @immunegirl @sm_blum @ Tom Moran @sitcancer

Excited to be at #SITC2024 - as faculty for the first time! 🤎 badge ribbons, which basically lay out my @sitcancer & @sitcancerECS journey 😀 Recruiting postdocs that are motivated to create effective immunotherapies for brain tumor patients! Reach out! http://Tymillerlab.org

I am honored and humbled to be appointed as the Paul and Betsy Shiverick Professor of Immuno-Oncology. I’m very grateful for generosity and the vision of Paul and Betsy to establish this Professorship &feel incredibly fortunate to be the inaugural chairholder @caseccc & @CWRUSOM!

Let's go Guards!!! @CleGuardians #thisiscleveland

Great to have @CouturierMDPhD visit the lab this week! Looking forward to many continued close collaborations, my friend!

Happy to support the @theABTA this morning in the first annual Cleveland BT5K! Thanks to my co-captain of the @caseccc team, @JustinLathia - proud to have @ClevelandClinic, @CWRUSOM, @UHhospitals researcher & docs team up! Cleveland is the place to be for #braintumor research!

The @TyMillerLab showed out this morning to support @theABTA as part of the @caseccc team! Love that the lab gets engaged supporting brain tumor research funding! Thanks @estrada__edward @Shawn_T_Ho @ReganMurphy20 @Vrishab_x & Meirola! #ClevelandBT5K

That's a wrap on #ReThinkNeuroimmunology 2024! Thanks to @IdoAmitLab and @jonykipnis for an incredible meeting with lots of thought-provoking presentations and conversations. Was honored to be able to present our work and ideas. Until next time!

Great to present our work on understanding and targeting immunosuppressive myeloid cells at #CRUKbrain2024 Also wonderful to get to catch-up with old and new friends! #braintumour