Glutamate is a major chemical messenger in the brain, and is fundamental for excitatory synaptic neurotransmission. This new discovery from CNC faculty members @jwadiche.bsky.social @wadichelabs.bsky.social reveals for the first time how glutamate concentration shapes glutamate receptor function.
Glutamate concentration tunes AMPA receptor function through conductance-state occupancy - Nature Neuroscience
This study shows that glutamate concentration at synapses can dynamically reshape how synaptic AMPA receptors pass current and calcium. This reveals a rapid way that synapses tune communication in the...
nature.com