UK MND Research Institute
@ukmndri.bsky.social
A national network of MND centres that work together to understand how #MND happens, what treatment works, and test possible treatments in clinical trials.
Join us for the 7th UCL Queen Square MND Centre ALS/MND International Symposium, in partnership with the UK MND RI. 📅 11 September 2026 | London & Zoom 🎟️ Free to register Speakers from Columbia, Oxford, Max Planck and more. Register below! www.eventbrite.co.uk/e/ucl-queen-...
UCL Queen Square MND Centre 7th ALS/MND International Symposium
One-day conference on emerging themes in ALS/MND research and in the clinic.
eventbrite.co.uk
New University of Sheffield research could shift how apathy in #MND is recognised and managed in clinical care, with practical implications for both clinicians and carers. Supported by TiM-R participants. Read more 👇 ukmndri.org/2026/07/23/r...
Apathy in MND: New Research on Effort vs Motivation
New Sheffield research suggests apathy in MND is often about effort, not motivation, recruited through Join MND Research. Read the findings.
ukmndri.org
Traditional clinical trials are essential, but for people with #MND, years of waiting isn't an option. EXPERTS-ALS uses short-term biomarker studies to identify promising treatments faster. Take a look at the first wave of drugs entering the platform. ukmndri.org/2026/04/22/b...
The first drugs entering EXPERTS-ALS — the UK's innovative MND treatment platform | UK MND Research Institute
EXPERTS-ALS is a UK-wide platform designed to rapidly test potential MND treatments. Meet the first three drugs — metformin, nifedipine, and ropinirole — now open to recruitment.
ukmndri.org
@mndassoc.bsky.social Grants are now open across a variety of areas, including PhD studentships and research fellowships. If you're working in #MND research, this is your window. Take a look at the link below. Apply👇 www.mndassociation.org/research/for...
Apply for funding
Discover how the MND Association leads global research to find a cure. Explore our cutting-edge grants and see how we fund the best science to defeat MND.
mndassociation.org
We're thrilled to announce that the drug RT1999 has been selected for EXPERTS-ALS. This is how we accelerate progress for people with MND. Participants are expected to receive the drug by the end of 2026. ukmndri.org/2026/03/10/n...
New MND drug selected for EXPERTS-ALS platform
Raya Therapeutic's smilagenin has been selected for EXPERTS-ALS. Read how this new drug could accelerate the search for MND treatments.
ukmndri.org
Today, we are celebrating the women driving MND research forward, from the lab bench and clinical trials to patient advocacy and care. Progress towards a cure is built on their vital work. Happy #InternationalWomensDay2026🔬
We're thrilled that the drug Neflamapimod has been selected for evaluation in our EXPERTS-ALS platform. 🧪 The drug will be tested on a small cohort of people living with ALS Read more below🔬 ukmndri.org/2026/02/24/n...
Industry partners are vital collaborators in our mission to find crucial new treatments for #MND/#ALS. Our co-director, @ammaralchalabi.bsky.social, teamed up with Raya Therapeutics at TRICALS to lead a discussion on Repurposing and Combination Therapies. Read more 👇 ukmndri.org/2025/11/13/r...
Three years after our launch, we’ve worked tirelessly to understand how and why MND occurs, identify promising treatments, and test them in clinical trials. Read about what we've achieved, together, in our first three years here: ukmndri.org/2025/12/17/u...
UK MND RI: Three Years of Progress in MND Research
Celebrating three years in MND research: building infrastructure, accelerating trials, and driving progress toward effective treatments.
ukmndri.org
🎉We're thrilled to announce that our biosampling platform has recruited 212 participants, surpassing our target of 200. This work will be vital in bringing us closer to new and more personalised treatments for #MND/#ALS.🔎 ukmndri.org/2025/12/12/b...
UK MND RI biosampling platform passes 200 recruits
Our biosampling platform has recruited 212 participants, exceeding its target and advancing biomarker research..
ukmndri.org
How are biomarkers are changing #ALS/#MND research?🔎 A new review from King's College London shows how specific biomarkers, such as neurofilament light chain (NfL), can accelerate trials and enable personalised medicine. 🔗 Read more 👇 ukmndri.org/2025/12/05/b...
Biomarkers in MND Clinical Trials
A new systematic review from KCL highlights how biomarkers, such as NfL, are enabling earlier treatment assessments and personalised medicine.
ukmndri.org
New research reveals what people with #MND/#ALS need when deciding on genetic testing: clear info, implications for family & tailored support.📃 This data can help inform decision aids to assist people when thinking about genetic testing. Read more🔗 ukmndri.org/2025/12/03/g...
Genetic Testing: What People Need to Make Informed Decisions
A new study reveals what people with MND need when deciding on genetic testing, including clear information and tailored support.
ukmndri.org
Our posters from ENCALS 2025 on findings from the MND Register are now published on our website. Click the link below to read about the epidemiological insights, incidence and prevalence, as well as gender differences in #MND/#ALS. mndregister.ac.uk/research-pap...
MND Research Papers - MND Register
Findings from the MND Register project will be published here, as well as via a patient newsletter. Results will also be disseminated through scientific publication, conference presentation and patien...
mndregister.ac.uk
We've hit 100 sign-ups to our Remote Research Platform! Thank you to everyone who has signed up; together, we’re building a more inclusive #MND/#ALS research community. 🔗If you haven't joined, sign up below! ukmndri.org/research/und...
Get involved in MND research from home - UKMNDRI
Get involved You can now take part in MND research without having to travel. In collaboration with researchers at the University of Sheffield, we’ve created a secure online platform that makes it s...
ukmndri.org
Drug development is a complex and costly process. By using medicines approved for other conditions, we can overcome barriers in drug development. Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS. ukmndri.org/2025/11/13/r...
Repurposed Drugs: Accelerating MND Treatment Discovery
Discover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research.
ukmndri.org
Yesterday, we attended @mndoddie5.bsky.social's Discovery Network Showcase 2025. Researchers, clinicians, industry partners, and people affected by #MND/#ALS discussed how the network can drive forward progress in better understanding MND and the development of new treatments.
Our Co-Director, Prof. @ammaralchalabi.bsky.social, gave a fantastic talk yesterday, hosted by @mndassoc.bsky.social, on #MND/#ALS genetics, why they matter and how discoveries are shaping new treatments. Thank you to everyone who joined in person & online! #MNDresearch #genetics
New research finds that #MND/#ALS may slow molecular transport and nerve cell growth before cells begin to die. These early changes could hold clues to how the disease starts and how to treat it. ukmndri.org/2025/10/24/e...
Cellular changes in sporadic ALS may reveal new treatment targets
A new study suggests that MND may slow molecular transport and cell growth before nerve cells die. This could help identify new therapeutic targets.
ukmndri.org
A new UK-wide study finds that people who experience a traumatic brain injury may face a higher short-term risk of developing MND. This risk appears temporary, suggesting injury may sometimes be an early consequence of undiagnosed disease. Read more👇 ukmndri.org/2025/10/21/t...
Traumatic brain injury linked to short-term MND risk
A new study finds traumatic brain injury linked to a short-term rise in MND risk, suggesting this may reflect early disease signs, not cause them.
ukmndri.org
We’re deeply sorry to hear that former England rugby captain Lewis Moody has been diagnosed with MND. His courage in sharing his diagnosis will raise vital awareness. Our thoughts are with Lewis and his family. We must find an effective treatment for #ALS/#MND. www.bbc.co.uk/sport/rugby-...
Lewis Moody: Former England captain reveals motor neurone disease diagnosis
Former England captain Lewis Moody says in an exclusive BBC interview he has
bbc.co.uk
This is fantastic news and highlights the importance of consistently funding collaborative science in neurodegenerative diseases. We are committed to doing the same for #MND/#ALS and finding new ways to successfully treat the disease. www.bbc.co.uk/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
bbc.co.uk
Sign up now to a special symposium in memory of Euan MacDonald MBE, hosted by the Euan MacDonald Centre for #MND Research. 📍 Edinburgh 📅 8–9 October 🔬 Cutting-edge MND/ALS research 🌍 Public sessions on SpeakUnique & Euan’s Guide euanmacdonaldcentre.org/euan-macdonald-tribute-symposium-2025
A tribute to Euan MacDonald: celebrating the Euan MacDonald Centre and Euan's legacy
A 1.5-day symposium showcasing current MND research, and a celebration of Euan's legacy, including Euan's Guide and SpeakUnique.
euanmacdonaldcentre.org
Fatigue affects nearly all people with #MND/#ALS, yet it's often overlooked. A new UK-wide study reveals how fatigue evolves, its severity, and its link to other symptoms. This can inform future research and care. 🔗Read more👇 ukmndri.org/2025/09/04/f...
One of Raya Therapeutic's compounds has been selected for our EXPERTS-ALS programme. A pioneering initiative designed to fast-track promising treatments for #ALS/#MND. Read more about the story and why it is so significant below👇 ukmndri.org/2025/09/03/r...
Raya Therapeutics compound selected for EXPERTS-ALS platform
Raya Therapeutic’s ALS/MND compound joins the UK EXPERTS-ALS trial, aiming to accelerate development of a new promising treatment.
ukmndri.org
🧠 The @ukmndri.bsky.social is an #MND powerhouse, accelerating progress towards new treatments and, ultimately, a cure. Read their article about how the #LongitudePrizeOnALS could be a game-changer for drug discovery in neurodegenerative diseases. 🔗 bit.ly/40Tmmsh @ammaralchalabi.bsky.social
Longitude Prize launched to accelerate AI-driven drug discovery
A new international challenge prize has been launched to transform drug discovery for ALS, the most common form of MND through AI.
ukmndri.org
A new study has identified a blood-based biomarker panel that can detect #ALS up to a decade before symptoms appear. Using machine learning and protein profiling, researchers found 33 proteins that distinguish ALS from other conditions. ukmndri.org/2025/08/28/2...
Protein signature could predict ALS a decade early
A new study has identified a blood-based protein signature that may predict ALS up to ten years before symptoms appear.
ukmndri.org
A simple finger-prick blood test could transform how #MND/#ALS is monitored. New research from @ucl.ac.uk shows that NfL levels from capillary samples match those from traditional blood draws, suggesting a more convenient and less invasive way to sample blood. ukmndri.org/2025/08/20/f...
Finger-prick blood test could offer less invasive monitoring in MND
A simple finger-prick blood test could revolutionise how motor neuron disease and other neurological conditions are monitored.
ukmndri.org
The first treatment for a form of #MND/#ALS has been approved in the UK. #Tofersen is authorised for SOD1 MND, demonstrating the potential of gene-targeted therapies. UKMNDRI RI partners @sheffielduni.bsky.social & @kingsioppn.bsky.social contributed to the trials. ukmndri.org/2025/07/31/f...
First treatment approved in the UK for rare genetic form of MND - UKMNDRI
The MHRA has approved the use of tofersen, the first licensed treatment in the UK for MND caused by a variation in the SOD1 gene.
ukmndri.org
We're thrilled to see the first research nurse recruited to the @mndassoc.bsky.social’s new #MND Research Nurse Network. The network will be essential in providing the support and expertise needed to create equitable access to trials for all🔎 Read more 🔗 www.mndassociation.org/media/latest...
First nurse recruited into MND Association’s Research Nurse Network
The ambitious £7.2 million Research Nurse Network will give more people diagnosed with motor neurone disease (MND) the opportunity to take part in vital research
mndassociation.org
