I am thrilled to announce that the completely redesigned TmDet algorithm by @ProtBioinfRG has just been published in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem!

doi.org

Structural basis of oligomerization-modulated activation and autoinhibition of orphan receptor GPR3. @CellReports Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9lyb

cell.com

#CryoEM #Structure of the Flagellar Motor Complex from Paenibacillus sp. TCA20. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9lu9

mdpi.com

Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2. @EMBOReports. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jfy

embopress.org

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ee8

nature.com

Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib. @CellReports Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zbs

cell.com

Mycobacterium tuberculosis CrgA Forms a Dimeric Structure with Its Transmembrane Domain Sandwiched between Cytoplasmic and Periplasmic β-Sheets... https://pdbtm.unitmp.org/entry/9nm2

pubs.acs.org

Structural basis for catalytic mechanism of human phosphatidylserine synthase 1. @CellDiscovery Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kqf

nature.com

Structural basis for cholesterol sensing of LYCHOS and its interaction with indoxyl sulfate. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j3x

nature.com

A structural and mechanistic model for BSEP dysfunction in PFIC2 cholestatic disease. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/

biorxiv.org

#CryoEM #structure of a phosphotransferase system glucose transporter stalled in an intermediate conformation. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hnp

sciencedirect.com

Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P2. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9do0

biorxiv.org

The completely redesigned TmDet algorithm by @ProtBioinfRG has just been accepted in the Nucleic Acids Research! Simple, double, curved membrane or even erroneously modeled tm proteins are no problem! Check it here: https://tmdet.unitmp.org.

The structural diversity of psychedelic drug actions revealed. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9arx

nature.com

Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters. @JBiolChem Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8zoj

jbc.org

Structural basis for the substrate recognition and transport mechanism of the human y+LAT1-4F2hc transporter complex. @ScienceAdvances Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kh5

science.org

Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jdm

nature.com

#CryoEM #structure of the human monocarboxylate transporter 10. @Structure Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9hhq

sciencedirect.com

Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel. @BJP Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ex6

bpspubs.onlinelibrary.wiley.com

#CryoEM #structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9b3j

nature.com

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9dhp

nature.com

Structure of the CD33 Receptor and Implications for the Siglec Family. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9bet

pubs.acs.org

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8u6z

researchsquare.com

#CryoEM #structures of mouse bestrophin 1 channel in closed and partially open conformations. Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9kc9

sciencedirect.com

Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. @Science Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jhj

science.org

Transport and inhibition mechanism for human TauT-mediated taurine uptake. @CellResearch Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9jvc

nature.com

Structure and mechanism of the plastid/parasite ATP/ADP translocator. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9j3j

nature.com

Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus. @Structure Check this #membrane #protein in UniTmp: https://pdbtm.unitmp.org/entry/9ilt

sciencedirect.com

The ABC transporter MsbA in a dozen environments. @Structure Check the #cryoEM #structure all of these #membrane #proteins in the UniTmp database: https://pdbtm.unitmp.org/entry/9fuq

ars.els-cdn.com

Narrowed pore conformations of aquaglyceroporins AQP3 and GlpF. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8y8n

nature.com