A two year post-doc in synthetic chemistry is available - working on plant alkaloids and terpenoids. The post is based with @unsworthchem.bsky.social as part of a close collaborations with my group and Prof Grogan in YSBL. Apply NOW, the deadline is the 9th April! jobs.york.ac.uk/vacancy/rese...

🔓Read a #OpenAccess paper in our latest issue by @prof-ian-fairlamb.bsky.social, @unsworthchem.bsky.social & co. @york.ac.uk reporting innovations to the ‘Clip-Cycle’ approach for functionalised pyrrolidines, pyrrolizidines and indolizidines #orgchem Find it in full🔽

‘Clip-Cycle’ approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines

The ‘Clip-Cycle’ approach is a versatile and modular synthetic method for the synthesis of aza-heterocycles via sequential cross metathesis and aza-Michael reactions. In this manuscript, a series of…

pubs.rsc.org

So pleased to share this work on alkaloid biosynthesis. Great collaboration with @unsworthchem.bsky.social. Well done to all authors. We have found key alkaloid producing enzymes that look like those normally found in bacteria. www.york.ac.uk/news-and-eve...

Plant discovery could lead to new ways of producing medicines

Scientists have shown how plants produce powerful natural chemicals that could help in the production of new medicines in more environmentally friendly ways.

york.ac.uk

New Phytologist@newphyt.bsky.social · 8mo ago

Parallel evolution of plant alkaloid biosynthesis from bacterial-like decarboxylases Wood et al. nph.onlinelibrary.wiley.com/share/HYPKAP...

New paper out today on alkaloid (bio)synthesis with @unsworthchem.bsky.social . Dr Lachlan Waddell made ten bioactive securinine alkaloids using "biomimetic" total synthesis - a strategy that we think is analogous to the plant makes the alkaloids by biosynthesis. pubs.rsc.org/en/content/a...

🔓Check out this #OpenAccess research by @unsworthchem.bsky.social ,Gideon Grogan & co @york.ac.uk in our latest issue describing cyclopropanation reactions by a class I unspecific peroxygenase #orgchem Read it in full below👇 pubs.rsc.org/en/content/a...

Cyclopropanation reactions by a class I unspecific peroxygenase

Non-natural biotransformations, such as alkene cyclopropanation through carbene insertion, have been demonstrated for the hemoproteins cytochrome P450 and myoglobin, but have not been investigated…

pubs.rsc.org

Clearing out my office and came across this much reused folder. You can just make out a scribbled date, 29 Jan 87, for a tutorial with Bruce Gilbert. So it's at least 38 yrs old. Channeling my inner womble, I think I'll keep it a little longer. @professor-dave.bsky.social @unsworthchem.bsky.social

Very happy to announce our latest paper - out today in Chemical Science A very enjoyable collaboration with @roly armRoly Armstrong on Stereoselective Synthesis of Atropisomeric Amides. doi.org/10.1039/D4SC05

🚨Funded PhDs available 🚨 2nd hiring round of the York-Oxford CDT in sustainable synthesis is open. Seeking a talented organic chemist to work with me, Gideon Grogan and Ed Anderson on a synthesis project using enzymes (#28). Inquiries welcome! cshp-cdt.chem.ox.ac.uk

Very happy to announced 2 new papers from the group in the last 24 hours! The first, Divergent Oxidation Reactions of E- and Z-Allylic Primary Alcohols by an Unspecific Peroxygenases, just out, with my amazing collaborator Prof Gideon Grogan onlinelibrary.wiley.com/doi/10.1002/...

Divergent Oxidation Reactions of E‐ and Z‐Allylic Primary Alcohols by an Unspecific Peroxygenase

Unspecific Peroxygenases (UPOs) catalyze the selective oxygenation of organic substrates using only hydrogen peroxide as the external oxidant. The PaDa-I variant of the UPO from Agrocybe aegerita cat...

onlinelibrary.wiley.com

Whisky night!

Happy to share our News and Views article on a very cool new ring expansion approached developed by Yifeng Chen and coworkers. Written with Jack Wootton, and just out in Nature Chemistry rdcu.be/d0ZAe

Cyclic amine ring expansion

Nature Chemistry - Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with their synthesis. Now, the conversion of 5- and 6-membered...

rdcu.be

Second post - major congratulations to Barbara Radzikowska for passing her viva.👩‍🎓 Thank you to examiners Dr Lianne Willems and Prof Chris Willis. Cosupervised by @unsworthchem.bsky.social . Seriously impressive project on complex alkaloid biosynthesis in Daphniphyllum. 🥳

Delighted to announce publication of the 2nd posthumous paper from the lab of our friend and colleague Prof Paul Clarke. With Saikiran Ravi, Chris Maddocks and Prof Ian Fairlamb We all miss you Paul – hope we have done the work justice pubs.rsc.org/en/Content/A...

Need something for my first post over here, so gone for a shameless plug of our JACS paper published earlier this year! Looking forward to interacting with you all again in a better and less angry place. pubs.acs.org/doi/10.1021/...

A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions

Macrocycles and medium-sized rings are important in many scientific fields and technologies but are hard to make using current methods, especially on a large scale. Outlined herein is a strategy by wh...

pubs.acs.org