Uwe Ohler

@uweohler.bsky.social

Scientist and music nerd. All things machine learning and genomics for gene regulation. Faculty at Max Delbruck Centrum and Humboldt University Berlin @mdc-berlin.bsky.social http://www.mdc-berlin.de/ohler Baritone at www.byrdland.org

To evaluate computational models, we rely on trusted benchmark data and metrics So what if a metrics is widely used… but plain wrong? It means that evaluations in dozens of papers are meaningless. This has happened in single cell genomics… (1/)

Nature Biotechnology@natbiotech.nature.com · last yr.

Shortcomings of silhouette in single-cell integration benchmarking - @uweohler.bsky.social @prauten.bsky.social @mdc-bimsb.bsky.social @mdc-berlin.bsky.social @humboldtuni.bsky.social go.nature.com/4fcQzZr

Finally!! “No government — regardless of which party is in power — should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue” Harvard president Alan M. Garber www.nytimes.com/2025/04/15/u...

Why Harvard Decided to Fight Trump

The Trump administration will freeze over $2 billion in federal funds because Harvard refused to comply with a list of demands. Harvard leaders believed saying no was worth the risk.

nytimes.com

PLOS has issued a statement on recent US Executive Orders and scientific integrity. We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry. plos.io/3D4O8cH

PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog

Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

plos.io

❓ What do you think about nf-core ❓ 🤔 We want your thoughts on the initiative, whether you are a user, developer, newcomer or veteran. ✏️ Fill out this short and anonymous <5min survey to help us guide the community! seqera.typeform.com/2025-nf-core #bioinformatics #nextflow #nfcore #pipelines

nf-core community survey 2025

This short 8-question survey aims to gauge the current feelings about the nf-core initiative and community. Say what you love and how we can make the community even better!

seqera.typeform.com

In which employees of a private company gain total access to files of every citizen, and government offices are stacked with ‚loyals‘. It makes me wonder, dear friends in the US: do you see it differently? Because from here, it does look like a coup. With a lot of added noise for distraction. 2/2

Uwe Ohler@uweohler.bsky.social · 2y ago

Tonight, the US correspondent of Austrian public broadcasting expressed consternation at the laissez faire of the American public that they are essentially victims to a coup. Not a military coup but one in which a billionaire‘s employees take over the government and fire public servants at will. 1/

Tonight, the US correspondent of Austrian public broadcasting expressed consternation at the laissez faire of the American public that they are essentially victims to a coup. Not a military coup but one in which a billionaire‘s employees take over the government and fire public servants at will. 1/

Important study from Pia @prauten.bsky.social in the lab: some popular evaluation metrics for #singlecell analysis #benchmarking are intrinsically flawed and report near optimal scores even when methods completely fail. This issue is found in dozens of papers. Read her thread for the whole story!

Pia Rautenstrauch@prauten.bsky.social · 2y ago

1/4 🧵 Preprint alert: In "Metrics Matter: Why We Need to Stop Using Silhouette in #SingleCell #Benchmarking," we reveal critical flaws in common #Evaluation metrics for #Integration and propose robust alternatives. @uweohler.bsky.social www.biorxiv.org/content/10.1...

So. the cowardly abandonment of fact checking and content moderation at #Meta makes it more urgent - how can we let our children use any social media? How can we educate to make use of the good things and support facts while not promoting fascism, autocrats, xenophobia, lgbtqia+phobia etc?