Multifunctional antibody responses from a primate Shigella outbreak inform vaccine design

An outbreak of Shigella in nonhuman primates enabled discovery of more than 100 protective and pathogenic antibodies against key vaccine antigens.

science.org

Multifunctional antibody responses from a primate Shigella outbreak inform vaccine design

An outbreak of Shigella in nonhuman primates enabled discovery of more than 100 protective and pathogenic antibodies against key vaccine antigens.

science.org

Supercharging the Superheroes of the Immune System

When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling the immune response...

primate.wisc.edu

What Wisconsin Researchers Learned About Zika Virus and Infant Development - NPRC

New Concern for Newborns Researchers from the University of Wisconsin–Madison, in collaboration with the National Primate Research Center (NPRC), found that Zika exposure during pregnancy may cause de...

nprc.org

Supercharging the Superheroes of the Immune System

When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling the immune response...

primate.wisc.edu

Supercharging the Superheroes of the Immune System

By Bekah McBride When illness strikes, white blood cells are the first cells on the scene. Much like a team of superheroes they each complete their specialized task, engulfing bacteria, controlling th...

stemcells.wisc.edu

What Wisconsin Researchers Learned About Zika Virus and Infant Development - NPRC

New Concern for Newborns Researchers from the University of Wisconsin–Madison, in collaboration with the National Primate Research Center (NPRC), found that Zika exposure during pregnancy may cause de...

nprc.org

Frontiers | Replicable generation and stable maintenance of rhesus macaque iPSCs for in vitro modeling of genetic frontotemporal dementia

At the Wisconsin National Primate Research Center, we have identified a family of rhesus carrying the microtubule-associated protein tau (MAPT) R406W mutatio...

frontiersin.org

David Abbott retires after decades of field-changing PMOS/PCOS research - Ob-Gyn UW-Madison

obgyn.wisc.edu

Frontiers | Replicable generation and stable maintenance of rhesus macaque iPSCs for in vitro modeling of genetic frontotemporal dementia

At the Wisconsin National Primate Research Center, we have identified a family of rhesus carrying the microtubule-associated protein tau (MAPT) R406W mutatio...

frontiersin.org

Monkeys Understand Shapes in Almost the Same Way as Humans (Gift Article)

Our geometric intuition, long considered something that sets us apart, seems to be shared with other primates.

nytimes.com

Mysterious orange-lipped monkey discovered deep in the Congo rainforest is a new species

“Likweli” find highlights importance of conservation work, researchers say

science.org

sciencedirect.com

CD8ɑ+ cells suppress SIV replication without the development of mutations within MHC class-I-restricted epitopes during post-treatment control | Journal of Virology

While rare, a subset of PLWH, termed post-treatment controllers (PTCs), maintains viral control following antiretroviral treatment (ART) interruption. However, little is known about whether this control reflects a complete absence of viral replication or continual, subclinical replication. Here, we address a key knowledge gap regarding how viral populations change during CD8ɑ+ cell-mediated PTC of SIV. We utilized our Mauritian cynomolgus macaque model of HIV infection, in combination with barcoded SIVmac239M and deep sequencing, to characterize viral lineages and MHC-I-restricted CD8+ T-cell epitopes throughout the study. Our findings demonstrate that early ART initiation limits viral diversity, that pre-ART replication predicts post-ART reactivation, and that CD8ɑ+ cells can suppress viral replication without the emergence of mutations within CD8+ T-cell epitopes. These insights establish MCMs as a valuable model for dissecting mechanisms of durable ART-free viral control and highlight the potential of CD8-mediated immune control as a therapeutic target for HIV cure strategies.

journals.asm.org

Biocompatible Glycoconjugation Enables Sensitive In Vivo Cell Tracking by PET/CT

Cell-based therapies have transformed the treatment landscape for cancer, yet their clinical translation remains limited by unpredictable in vivo behavior and variable patient responses. Accurate, non...

pubs.acs.org

madison.com

TRANSLATIONAL CONVERSATIONS | BRAD

bradglobal.org

CD8ɑ+ cells suppress SIV replication without the development of mutations within MHC class-I-restricted epitopes during post-treatment control | Journal of Virology

While rare, a subset of PLWH, termed post-treatment controllers (PTCs), maintains viral control following antiretroviral treatment (ART) interruption. However, little is known about whether this control reflects a complete absence of viral replication or continual, subclinical replication. Here, we address a key knowledge gap regarding how viral populations change during CD8ɑ+ cell-mediated PTC of SIV. We utilized our Mauritian cynomolgus macaque model of HIV infection, in combination with barcoded SIVmac239M and deep sequencing, to characterize viral lineages and MHC-I-restricted CD8+ T-cell epitopes throughout the study. Our findings demonstrate that early ART initiation limits viral diversity, that pre-ART replication predicts post-ART reactivation, and that CD8ɑ+ cells can suppress viral replication without the emergence of mutations within CD8+ T-cell epitopes. These insights establish MCMs as a valuable model for dissecting mechanisms of durable ART-free viral control and highlight the potential of CD8-mediated immune control as a therapeutic target for HIV cure strategies.

journals.asm.org

sciencedirect.com

A First for Parkinson’s: Autologous Cell Therapy Moves from the Wisconsin National Primate Research Center to Human Trials - NPRC

A new investigational treatment for Parkinson’s disease is showing early promise in its first human clinical trial, thanks in part to foundational work at the University of Wisconsin–Madison and the W...

nprc.org

Heart Regeneration Research in Nonhuman Primates: A Model for Ventricular Pressure Overload | Office of Research Infrastructure Programs (ORIP) – DPCPSI – NIH

Congenital heart defects are the most common type of birth defect in the United States and can result in heart failure early in life. Stem cell grafts offer potential as a treatment for cardiac defect...

orip.nih.gov

Heart Regeneration Research in Nonhuman Primates: A Model for Ventricular Pressure Overload | Office of Research Infrastructure Programs (ORIP) – DPCPSI – NIH

Congenital heart defects are the most common type of birth defect in the United States and can result in heart failure early in life. Stem cell grafts offer potential as a treatment for cardiac defect...

orip.nih.gov

Ending animal testing could set back xenotransplantation just as the field is poised for a breakthrough

“Innovations like xenotransplantation would never have reached clinical trials without animal experimentation,” writes transplant surgeon Joshua Mezrich.

statnews.com

A First for Parkinson’s: Autologous Cell Therapy Moves from the Wisconsin National Primate Research Center to Human Trials - NPRC

A new investigational treatment for Parkinson’s disease is showing early promise in its first human clinical trial, thanks in part to foundational work at the University of Wisconsin–Madison and the W...

nprc.org

SIRPα ablated iPSC-derived macrophages resist hypophagia and exhibit superior mAb-dependent and CAR-mediated cytotoxicity of solid tumors

Smith and colleagues report that SIRPA knockout iPSC-derived macrophages possess enhanced antitumor activity against various CD47-expressing tumors when combined with cancer-targeted monoclonal antibo...

cell.com

mdpi.com