Atlas of Variant Effects Alliance
@varianteffect.bsky.social
Advancing the promise of the Human Genome Project by interpreting the landscape of human genetic variation. https://www.varianteffect.org https://www.linkedin.com/company/atlas-of-variant-effects-alliance #AtlasOfVariantEffects
Don't forget, we'll be live later for our Variant Effects Seminar. Today's talk is with @sarahgurev.bsky.social. Find your time zone and join us at 4.00 pm (UTC): www.varianteffect.org/seminar-seri...
Our Variant Effects Seminar Series returns next Tuesday, August 4! Join @sarahgurev.bsky.social for her presentation, 'Towards reliable viral mutation effect prediction for pandemic preparedness'. Discover Sarah's work and get the event joining info: www.varianteffect.org/seminar-seri...
Some of our Virology Interest Group have authored a review of the recent technological & conceptual advances in the deep mutational scanning methods being applied to virology. Also covered are the insights these advances are yielding & suggestions for future studies. Read now: tinyurl.com/84dcy96z
Scanning the horizon: deep mutational scanning approaches in virology | Journal of Virology
The development of deep mutational scanning (DMS) approaches has led to a fundamental shift in our ability to connect viral genotype and phenotype (1) and accelerated our understanding of viral evolut...
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As our Variant Effect Seminar Series (VESS) returns, we caught up with two of our earliest speakers, Mafalda Dias & Jonathan Frazer. Now group leaders at the Centre for Genomic Regulation (CRG) in Barcelona, we explore the role of VESS in their journey. Read their interview: tinyurl.com/m4ncw2nf
Mark your calendars for the next instalment of our Variant Effects Seminar Series. 🗓️ On August 4, Sarah Gurev will be our sole speaker, with her extended presentation, 'Toward reliable viral mutation effect prediction for pandemic preparedness'. More info: tinyurl.com/4ms3mmzy
You can still register for, 'Unmasking the Genome: Integrating WGS, AI and Functional Genomics', from 1-4 September at the University of Exeter, UK. The workshop is for all researchers working at the leading edge of genomic science. 🧬 Get the programme and register now: tinyurl.com/4vbrp63p
Unmasking the Genome: Integrating WGS, AI and Functional Genomics - UK Human Functional Genomics Initiative
Unmasking the Genome is a four-day advanced workshop designed for researchers working at the leading edge of genomic science. This programme brings together expertise from Google DeepMind, leaders in ...
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The new publication by members of the Atlas of Variant Effects Clinical Variant Interpretation working group provides guidance for combining data from multiple MAVEs to strengthen the functional evidence for clinical variant classification. Read now: tinyurl.com/yn6bkhhn
Combining multiplexed functional data to improve variant classification - Genome Medicine
Background With the surge in the number of variants of uncertain significance (VUS) reported in ClinVar in recent years, there is an imperative to resolve VUS at scale. Multiplexed assays of variant e...
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The latest episode of the Variants and Us (VUS) podcast explores how MAVEs are made with two scientists (@kmatreyek.bsky.social and @gregfindlay.bsky.social) that have transformed the generation of phenotypic data for thousands of variants simultaneously. Listen now: tinyurl.com/3kv774ee
Inside the toolbox: how MAVEs are made
Variants and Us (VUS) Podcast · Episode
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Our Variant Effects Seminar Series (VESS) is taking a break this month, but will be back on August 4 with an extended presentation from @sarahgurev.bsky.social, 'Towards reliable viral mutation effect prediction for pandemic preparedness'. Discover VESS and all speakers: tinyurl.com/4atzepeb
Our Variant Effects Seminar Series (VESS) is organized and led by a committee of early career scientists. We asked Priyanka Bajaj and @ohannab.bsky.social about their experiences on the VESS committee, as they depart for new adventures in variant science. Read now: tinyurl.com/lifeaftervess
Missed Abbye McEwan's excellent introduction to MAVE technology? It's now available on YouTube: www.youtube.com/watch?v=FeUp... Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.
VSN presents Beyond the VUS Using MAVE Data to Inform Clinical Variant Classification
YouTube video by Variant Scientists Network
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Did you know you can find all the Variant Effects Seminars on the AVE YouTube channel? Established in 2021, the seminar series reached its 100 speaker milestone last month. So, there are plenty of great talks to choose from. Find your next watch: tinyurl.com/AVE-VESS #AtlasOfVariantEffects
Why should you attend MSS 2027? We asked PhD student Rebeca Olvera-León about her experiences at the last four MSS events, and found out what she was most looking forward to for MSS 2027: bit.ly/4eHgiJz Tell us, what do you hope is on the program for MSS 2027?
We are delighted that Jay Shendure will be a keynote speaker at MSS 2027. He says, "It's phenomenal to see the community that AVE has grown in to, and the impact that it's having. I'm excited to have the opportunity to share some perspective and our latest work." www.varianteffect.org/mss2027/
It's exactly 1 year until the 10th anniversary MSS 2027 in Seattle! MSS unites the functional genomics community, fostering field-defining discussions and collaborations. Co-organizer, Doug Fowler, PhD, discusses the event: bit.ly/4wbDzKV #VariantEffect27 #AtlasOfVariantEffects
Don't miss Abbye McEwen's deep dive into interpretation of variants of unknown significance (VUS) - happening today (12.00 pm ET / 9.00 am PT / 5.00 pm BST). Join here: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #AtlasOfVariantEffects
This Wednesday, are you ready to go beyond the VUS and learn more about using multiplexed assays of variant effects (MAVEs) to inform clinical variant classification? It's free to sign up: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #VUS #MAVE #AtlasOfVariantEffects
At last week's Variant Effects Seminar (VESS), @eag91.bsky.social discussed disentangling the biophysical effect of missense variants using protein dark energy. If you missed it, you can now watch it on our YouTube channel at a time to suit you. ⏯️ youtu.be/je5XosFTLPY
Disentangling the biophysical effect of missense variants using protein dark energy - E. A. Galpern
YouTube video by Variant Effects
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Last week our Variant Effects Seminar Series (VESS), reached its 100th speaker. Are you in our gallery? Let us know! VESS is led by and exists for early career scientists, enabling them share their work on interpreting human genetic variation. Learn more: www.varianteffect.org/seminar-seri...
MAVEs are transforming how labs evaluate genetic variants, providing functional evidence at scale. Join Dr Abbye McEwen for an introduction to MAVEs and to learn how these datasets may help resolve variants of uncertain significance. Register free: bit.ly/3Seq0LL #AtlasOfVariantEffects
@tylernstarr.bsky.social of the University of Utah recently presented for the AVE Virology Interest Group on his latest research into SARS-CoV-2 variants using deep mutational scanning. Watch now and subscribe: youtu.be/hQ6ArFcOwPA #AtlasOfVariantEffectsAlliance
“Deep mutational scanning of recent SARS-CoV-2 variants" - Tyler Starr
YouTube video by Variant Effects
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Happening today – don't miss out! Join here: www.varianteffect.org/seminar-seri... at ⏰ 9.00 (Pacific) ⏰ 12.00 (Eastern) ⏰ 17.00 (BST) ⏰ 18.00 (CEST)
Atlas of Variant Effects Alliance@varianteffect.bsky.social · 2mo agoJoin us tomorrow for a special VESS seminar, as we mark our 100th speaker milestone with a talk from postdoctoral researcher, Ezequiel Galpern. We also have some special guests, as we look to the next 100 speakers! Joining info: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects
Join us tomorrow for a special VESS seminar, as we mark our 100th speaker milestone with a talk from postdoctoral researcher, Ezequiel Galpern. We also have some special guests, as we look to the next 100 speakers! Joining info: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects
Join us, next Tuesday as we mark 100 speakers in VESS! After Ezequiel Galpern's presentation we will celebrate our first 100 speakers and a look to the future of this fantastic early-career seminar series. See you there ➡️ www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects
Our Variant Effect Seminar Series is marking a milestone! Join us on Tuesday, June 2, for our 100th speaker, Ezequiel Galpern. Plus, special VESS guests, as we celebrate and look forward to the next 100 speakers! Join here: www.varianteffect.org/seminar-seri... #AtlasOfVariantEffects
Both talks from the May episode of the Variant Effects Seminar Series (VESS) are now available to watch on our YouTube channel ⏯️ bit.ly/4ud02Xa. Catch up with Thea Klarsø Schulze and Jerome Freudenberg's presentations anytime! #Genomics #VariantInterpretation #AtlasOfVariantEffects
Catch up on all 3 days' talks from the Mutational Scanning Symposium (MSS) 2026 on our YouTube channel ⏯️ bit.ly/4diP7FD Whether you're watching for the first time or revisiting a favorite talk, there's something insightful to enjoy! #VariantEffect26 #AtlasOfVariantEffects
You can now find the Day 2 presentations from the MSS 2026 over on our YouTube channel. ⏯️ bit.ly/4tzo9hQ The final day's talks will be live soon, so watch this space! #VariantEffect26 #Genomics #DeepMutationalScanning #FunctionalGenomics #AtlasOfVariantEffects
Day 1 presentations from the Mutational Scanning Symposium (MSS) 2026 are now available on our YouTube channel: www.youtube.com/playlist?lis... Check back again soon for days 2 and 3 of MSS 2026! #VariantEffect26 #AtlasOfVariantEffects
MSS26 Day 1 - YouTube
Presentations from the Mutational Scanning Symposium (MSS) 2026, held March 25-27 in Melbourne, Australia.
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