Our new study evaluated magnetically responsive PLGA-MNPs for a stent-targeted drug delivery platform. Magnetic field exposure increased nanoparticle attachment to stents and drug detection in release assays. doi.org/10.1016/j.vp...

Aspirin may do more than stop platelets. Could it also reshape fibrin clots? This review explores how fibrinogen acetylation may alter clot structure, cross-linking, permeability, and breakdown, and why the clinical impact of this extra-platelet effect remains uncertain. #Thrombosis

New Review. This review explores the CAV1–EV axis as a key link between endothelial dysfunction, vascular aging, cardiovascular disease, and frailty, highlighting its potential as a biomarker and therapeutic target. #VascularBiology #Aging #CardiovascularResearch #Frailty doi.org/10.1016/j.vp...

Our recently published study highlights that ouabain's vascular effects depend on the contracting stimulus. Na⁺/K⁺-ATPase–Src pathway enhances Ca²⁺ sensitization, while BKCa channels act as a brake on excessive vasoconstriction. doi.org/10.1016/j.vp...

Not all TAVR patients carry the same stroke risk. In severe PAD patients treated via transfemoral access, combining CHA₂DS₂-VASc with the HOSTILE anatomical score improved prediction of 30-day CVA, highlighting the value of integrating clinical and anatomical risk for smarter prevention. #Cardiology

Our recently published study highlights that ouabain's vascular effects depend on the contracting stimulus. Na⁺/K⁺-ATPase–Src pathway enhances Ca²⁺ sensitization, while BKCa channels act as a brake on excessive vasoconstriction. doi.org/10.1016/j.vp...

Our new review highlights the importance of endothelial interface and transport barrier in vascularized tumor organoid models. The future lies in quantifying vascular transport, AI-driven analysis, and patient-specific models for precision oncology doi.org/10.1016/j.vp...

Cannabinoids can relax blood vessels, but is PPARγ truly involved, or are off-target drug effects and ion channels driving the response? This focused review challenges assumptions, weighs the evidence, and calls for better tools to decode vascular cannabinoid signaling. #VascularBiology'

Our recently published review highlights the importance of CMR in acute myocardial infarction (AMI) care. Emphasis on faster imaging, AI-assisted analysis, and integration with CT could be the future in clinical care after AMI doi.org/10.1016/j.vp...

Sex-specific differences in lineage-derived VSMCs may help explain why Stanford type A TAAD occurs more often in men. Female VSMCs showed enhanced ECM-related gene expression linked to greater mechanical resilience. #TAAD #AorticAneurysm #VascularBiology #CardiovascularResearch #scRNAseq

New review: m6A RNA methylation plays a key role in VSMC phenotypic switching and vascular disease pathogenesis. Targeting m6A writers, erasers, and readers may offer new therapeutic opportunities for vascular disorders. #VascularBiology #Epigenetics #RNAbiology #m6A #VSMC #CardiovascularResearch

Our recently published study reveals that the 21-amino-acid C-terminal domain of CaMKIIδ2 drives vascular smooth muscle cell migration via FYN kinase, a potential target for pathological vascular remodeling. 10.1016/j.vph.2026.107651

Impaired RV-PA coupling during exercise is linked to pulmonary congestion in HFrEF/HFmrEF patients, especially in those with elevated peak PAPs. Findings highlight a key mechanism driving exercise-induced EVLW increase #HeartFailure #Cardiology #Echocardiography #PulmonaryHypertension #HFmrEF #HFrEF

Heavy legs, swelling, pain, can venoactive drugs improve chronic venous disease care? This expert review spotlights micronized purified flavonoid fraction as a leading option for easing symptoms and improving quality of life, while weighing evidence for other therapies. #VascularPharma #VenousHealth

New hope for small abdominal aortic aneurysms? This meta-analysis shows anti-inflammatory therapies not only slowed AAA progression in mice, but were the only treatments linked to reduced rupture risk. A promising step toward translational AAA therapy.#AAA #VascularPharmacology #Inflammation #Cardio

Does pyroptosis drive thoracic aortic dissection? In a BAPN mouse model, knockout of Caspase-11 or GSDMD failed to alter TAD outcomes, challenging assumptions about non-canonical pyroptosis in aortic disease. Negative results, big implications. #VascularBiology #AorticDissection #Pyroptosis #Cardio

What happens when the lung can’t utilize more capillaries during exercise? First direct measurements in severe pulmonary arterial hypertension show impaired functional capillary surface area recruitment, even at maximal dyspnea. #VascularPharmacology #PAH #PulmonaryHypertension #ExercisePhysiology

Our new review analyzes the mechanistic link between chronic venous insufficiency (CVI) and cardiovascular risk, proposing to integrate proactive cardiovascular screening for CVI patients to improve long-term prognosis. doi.org/10.1016/j.vp...

A prospective study analyzed long-term survival in a real-world heart failure cohort and identified significant gaps in guideline-directed therapy. Bridging guideline recommendations and practice through early risk stratification and multicomponent therapy is key to improving survival.

Angiogenesis research is entering a new era 🧬 Our latest review maps in vitro, ex vivo & in vivo assays and integrates AI imaging, spatial transcriptomics & CRISPR to guide smarter assay selection. A decision matrix + algorithm for reproducible, translational science.

NEW article 🎉 mTORC1 (via RAPTOR) rewires amino acid metabolism in lymphatic endothelial cells, disrupting glutaminolysis, altering BCAA handling, and impacting vessel formation. Metabolism is central to lymphatic biology. #mTORC1 #Lymphatics #Metabolism #VascularBiology doi.org/10.1016/j.vp...

Extracellular vesicles (EVs) link vascular inflammation and coagulation. Our recently published review article proposes a unified mechanistic model that defines the common molecular drivers of EV thrombogenicity, advancing EVs towards precise clinical tools. doi.org/10.1016/j.vp...

Our systematic review on sodium nitroprusside highlights its pharmacology, clinical applications, and safety considerations in cardiovascular health. It also emphasizes the need for individualized dosing strategies to maximize long-term clinical impact and minimize toxicity. doi.org/10.1016/j.vp...

Benzo[a]pyrene (BaP) worsens atherosclerosis via SPP1-driven macrophage inflammation and lipid dysregulation. Integrative omics with cellular validation reveal SPP1 as a potential target in pollution-related vascular disease. #Atherosclerosis #EnvironmentalHealth #SPP1 doi.org/10.1016/j.vp...

New research shows low-dose colchicine disrupts macrophage microtubules,slashes cell footprint & matrix degradation, and reduces motility, uncovering a potential mechanism behind its CV protection in atherosclerosis. Inflammation meets cytoskeleton #Atherosclerosis#Colchicine doi.org/10.1016/j.vp...

Preeclampsia may shape brain health long after pregnancy. This review explores how angiogenic imbalance, endothelial dysfunction, and AD-related proteins could link PE to later cognitive decline, highlighting pathways for potential drug repurposing. #Preeclampsia #Alzheimers #WomensHealth

Can routine MRA predict which brain aneurysms will rupture? Our latest article shows how patient-specific CFD tool maps hidden blood-flow forces, revealing shear-stress patterns that distinguish stable from high-risk lesions, advancing noninvasive, personalized care #Neurosci #CFD #StrokePrevention

Our review examines chamber-specific expression and function of ion channels in the human heart. This comprehensive and integrative analysis could serve as a basis for developing therapeutic strategies for improved patient care. doi.org/10.1016/j.vp...

New article: This study reveals that EndMT contributes to atherosclerosis by generating osteogenic- and chondrogenic-like cells, linking endothelial dysfunction to vascular calcification in disease #EndMT #Atherosclerosis #VascularBiology #CardiovascularScience doi.org/10.1016/j.vp...

A new observational study using INSPECTIO supports the effectiveness of guideline-directed therapy and regular risk assessment to optimize treatment strategies in Pulmonary Arterial Hypertension. #PAH #ClinicalResearch #INSPECTIO #ObservationalStudy #Macitentan #Selexipag doi.org/10.1016/j.vp...