The Immunobuddies

Podcast · Dr Ricky Frazer and Dr Anna Olsson-Brown · Buddies with an interest in the area of immunotherapy and its development. We simply discuss the dilemmas, challenges and progress made in the mana...

open.spotify.com

A UK Delphi consensus study on the definition and management of advanced cutaneous squamous cell carcinoma

Advanced cutaneous squamous cell carcinoma (acSCC) encompasses locally advanced and metastatic disease; however, no standardized definition exists. Recognition and categorization, therefore, often ...

tandfonline.com

UK Photon Radiotherapy Practice for Oligodendroglioma –Data From the Analysis of Proton vs Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health Trial (ISRCTN:1339049) Radiothera...

The APPROACH (Analysis of Proton vs Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health) trial is a UK randomised controlled study comparing photon radiotherapy (RT) with proto...

clinicaloncologyonline.net

Three layers and two revelations: A multidisciplinary framework for curating real-world data from electronic patient records reveals a decade of breast screening performance

AbstractObjectives. To develop and validate a scalable, semi-automated framework for extracting high-granularity research data from legacy Electronic Patie

academic.oup.com

Growing palliative and end-of-life care research in the United Kingdom: Findings from a mixed methods survey

Background Globally the number of people with an advanced progressive illness is increasing. Research is essential to inform policy, services and clinical practice to meet their needs. We investigated...

journals.plos.org

Quality of life and pain-response after stereotactic ablative radiotherapy of oligometastatic bone metastases in the phase 2 BONY-M trial

Bones are a common metastatic site for many cancers, including lung, breast, and prostate cancer [1]. Bone metastases are a frequent source of cancer-related pain and can lead to debilitating complica...

thegreenjournal.com

Patient-clinician symptom agreement before and after radiotherapy for prostate cancer: results from the randomized HYPO-RT-PC study

Prostate cancer (PC) is among the most common cancers in men worldwide [1]. Symptoms are frequent across treatment modalities and may persist long after therapy [2]. External beam radiotherapy (RT), a...

thegreenjournal.com

OPEN: optimising patient experience in head and neck radiotherapy, a phase 3 randomised control trial comparing open versus closed face masks

Radiotherapy remains a cornerstone of treatment for > 70% of patients with head and neck cancer [1]. Accurate dose delivery requires accurate immobilisation, traditionally achieved using thermoplastic...

thegreenjournal.com

Long-term safety of first-line osimertinib plus platinum–pemetrexed in EGFR-mutated advanced NSCLC: FLAURA2

Until 2024, the preferred first-line treatment for epidermal growth factor receptor (EGFR)-mutated (exon 19 deletion or L858R) advanced non-small cell lung cancer (NSCLC) was osimertinib, a third-gene...

lungcancerjournal.info

PDS0101 With Pembrolizumab in HPV16-Positive Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

This nonrandomized clinical trial examines the efficacy and safety of PDS0101 in combination with pembrolizumab in human papillomavirus 16–positive resistant/metastatic head and neck squamous cell car...

jamanetwork.com

Long-term efficacy and safety of avutometinib + defactinib in recurrent low-grade serous ovarian cancer: Results of a 2-year follow-up of ENGOT-OV60/GOG-3052/RAMP 201

In a phase 2 study, avutometinib (RAF/MEK clamp) and defactinib (FAK inhibitor) demonstrated efficacy in patients with recurrent low-grade serous ovarian cancer (LGSOC). Here, we report updated safety and efficacy data with 2 years of follow-up.

gynecologiconcology-online.net

70-gene signature MammaPrint for early-stage HR-positive, HER2-negative breast cancer: outcome in the MINDACT trial for key clinical-pathological high-risk subgroups

Adjuvant chemotherapy (ACT) can be safely omitted in patients above 50 years of age with stage I-II hormone receptor positive (HR+) HER2-negative (HER2-) breast cancer and a low-risk 70-gene signature...

ejcancer.com

Patient-reported symptom monitoring in patients with lung cancer (SYMPRO-Lung trial): long-term, post-hoc survival results of a multicentre, stepped-wedged, cluster-randomised clinical trial

Weekly PRO symptom monitoring was associated with meaningful improvement in long-term overall survival among patients with stage I–IV lung cancer. Median overall survival was 5 months longer in the in...

thelancet.com

Radiation Therapy for Bladder Cancer: An ASTRO Clinical Practice Guideline

This guideline provides evidence-based recommendations addressing the indications for radiation therapy (RT) for bladder cancer in a variety of clinical settings, ranging from patients with localized ...

practicalradonc.org

sciencedirect.com

Pembrolizumab plus chemotherapy as first-line therapy for advanced HER2-negative gastric or gastroesophageal junction adenocarcinoma: 4.5-year follow-up from the randomized phase III KEYNOTE-859 study

KEYNOTE-859 showed a favorable benefit–risk profile for pembrolizumab plus chemotherapy compared with placebo plus chemotherapy, regardless of programmed death-ligand 1 (PD-L1) status, in participants...

esmoopen.com

NCCN Guidelines® Insights: Esophageal and Esophagogastric Junction Cancers, Version 4.2026

Esophageal cancer is the seventh leading cause of cancer-related deaths worldwide. Esophageal cancers are histologically classified as squamous cell carcinoma (ESCC) or adenocarcinoma (EAC), which dif...

jnccn.org

B-Cell Lymphomas, Version 4.2026, NCCN Clinical Practice Guidelines In Oncology

Mantle cell lymphoma (MCL) is a heterogenous subtype of B-cell non-Hodgkin lymphoma (NHL). The treatment landscape of newly diagnosed MCL has evolved in recent years with the incorporation of covalent...

jnccn.org

Deep learning-based CT model for non-invasive prediction of tertiary lymphoid structures in pancreatic cancer: a multicenter study with prospective validation in an immunochemotherapy cohort

Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Tertiary lymphoid structures (TLS) have emerged as key components of the tumor immune microenvironment, ...

jitc.bmj.com

Neoadjuvant chemoimmunotherapy with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-2): an open-label, single-arm, phase 2 study

Background While immune checkpoint inhibitor-based neoadjuvant therapy shows promise in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), the optimal regimen has yet to be established...

jitc.bmj.com

Expansion of the world health organization (WHO) gastric neuroendocrine tumor classification: introducing types 4 and 5

Abstract. The 6th Edition of the World Health Organization Classification of Digestive System Tumours has introduced two new categories of gastric neuroend

academic.oup.com

Effectiveness of an eHealth intervention to improve quality of life in long-term breast cancer survivors: a 9-month randomized controlled trial

AbstractBackground. Quality of life may deteriorate in long-term breast cancer survivors after treatment. Evidence on the long-term effectiveness of eHealt

academic.oup.com

End-of-life sedation and gendered narrative registers: a longitudinal qualitative study of spouses bereaved by cancer - Supportive Care in Cancer

Purpose This study investigates gendered narrative registers in spousal grief following cancer, within this sample and interview context, in palliative care settings including continuous deep sedation...

link.springer.com

Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial - Supportive Care in Cancer

Purpose To explore the effectiveness and safety of self-acupressure intervention on the fatigue-sleep disturbance-depression symptom cluster (FSDSC) among breast cancer (BC) survivors and to explore w...

link.springer.com

Breast Cancer Screening in Pregnant and Lactating Patients: A Practical Approach | RadioGraphics

Breast cancer screening is increasingly performed during pregnancy and lactation owing to delayed childbearing and improved identification of high-risk individuals, highlighting the importance of c...

pubs.rsna.org

Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy | NEJM

Tambotatug pelitecan (known as Tam-Peli, a new antibody–drug conjugate that targets the immune-checkpoint molecule B7-H3) showed promising clinical efficacy in patients with relapsed extensive-stag...

nejm.org

nejm.org

Colonoscopy Intervals and Colorectal Cancer Incidence after Adenoma Removal | NEJM

More evidence is needed to inform recommendations for intervals of colonoscopy surveillance after polyp removal. In this ongoing noninferiority trial conducted in eight European countries, we rando...

nejm.org

ASCO Publications

ascopubs.org

Early Termination of Phase II-III Genitourinary Oncology Trials: A Two-Decade Analysis of Causes and Trial-Level Risk Factors | JCO Oncology Practice

PURPOSEEarly termination of clinical trials delays scientific progress and wastes resources, yet factors associated with trial completion in genitourinary (GU) oncology remain incompletely characteriz...

ascopubs.org