3.5/3 This paper was amongst others driven with great care and supervision from @huveneerslab.bsky.social @anaangulo.bsky.social @vessel-integrity.bsky.social @aicjanelia.bsky.social

3/3 doi.org/10.1083/jcb.... 🐟 validated that SNX9 and PACSIN2 are required for collective cell migration in the common cardinal vein in zebrafish

2/3 doi.org/10.1083/jcb.... 💡 found that all 3 exhibit different dynamics & correlate with different stages of junctional remodeling 😱 discovered that SNX9 is essential to internalize junctions remodel, allowing cell movement

1/3 Find our new publication doi.org/10.1083/jcb.... where we 🔬 characterize the 3D membrane ultrastructure of interacting cells during migration. 🔎 found 18 curvature sensing BAR proteins that localize to endothelial cell-cell junctions 🔦 studied the dynamics of 3 proteins in exquisite detail

How do your cells hold hands when they move together? Find our new publication where the cell membrane, BAR proteins, cell-cell junctions, and the common cardinal vein all dance together to form a healthy vasculature

Journal of Cell Biology@jcb.org · last wk.

Janssen, Angulo-Urarte, et al. @huveneerslab.bsky.social @uva.nl show that nanoscale membrane curvatures at asymmetric endothelial cell–cell junctions serve as a scaffold to recruit BAR proteins, including BIN1 and SNX9, during collective migration. rupress.org/jcb/article/...

Fluorescence Friday! The formation of the common cardinal vein in zebrafish is an intruiging phenomenon. Endothelial cells migrate and delaminate all the while blood flow is rushing through this open-ended tube. Which is your favourite observation? Tg(kdrl-EGFP) transgenic lines 30-38 hpf

Moving to this platform and start enjoying the science atmosphere here 🔬 #developmentalbiology #collectivecellmigration #vascularbiology #regeneration #microscopy