VJOncology
@vjoncology.bsky.social
The Video Journal of Oncology is dedicated to providing up-to-date information & international expertise 🩺 🎥 🗞️ #BCsm #LCsm #GUsm #GIsm #PCsm #CRCsm
Terence Friedlander, MD, shares 3.5-year #EV103 Cohort K data at #ESMO25 — enfortumab vedotin + pembrolizumab continues to show durable responses & survival benefits in 1L la/mUC. 🎥 Watch: buff.ly/kWn5KkI #UroOnc #UroSoMe #Blcsm #ImmunoOnc #CTSM #TrialUpdate
EV-103 Cohort K: long-term outcomes of EV ± pembrolizumab in la/mUC - VJOncology
Terence Friedlander, MD, University of California, San Francisco, CA, discusses updated results from Cohort K of the Phase Ib/II EV-103...
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At #ESMO25, Dr Llombart Cussac presents #EMPRESS trial results: giredestrant led to greater Ki67 reduction and stronger ER/PR decreases vs tamoxifen in premenopausal ER+/HER2- early #BreastCancer. 🎥 Watch: buff.ly/vLWxnoe #BCSM #CTSM #TrialUpdate #Oncology
EMPRESS: giredestrant vs tamoxifen in ER+/HER2- early breast cancer - VJOncology
Antonio Llombart Cussac, MD, PhD, Arnau de Vilanova Hospital of Valencia, Valencia, Spain, discusses results from the Phase II EMPRESS...
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🎥Janice Wing-Hang Tsang, MBBS, MRCP, FRCP, @HKUniversity, shares highlights from the #MetastaticBreastCancer track at #ESMO25 - including updates from VIKTORIA-1, novel ADCs in #TNBC, and PRO/QoL insights. Watch here ➡️ buff.ly/E4FLjXD #BreastCancer #BCSM #CTSM #TrialUpdate #ImmunoOnc #ESMO25
Metastatic breast cancer updates at ESMO 2025 - VJOncology
Janice Wing-Hang Tsang, MBBS, MRCP, FRCP, University of Hong Kong, Hong Kong, China, provides an overview of the metastatic breast...
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Emmanuel Seront, MD, PhD, discusses the Phase II RENALUT trial of 177Lu-PSMA-617 in metastatic ccRCC post-TKI/IO therapy, exploring PSMA-targeted radioligand therapy as a new option for resistant disease 🎥 buff.ly/dLhijGf #KidneyCancer #KCSM #CTSM #TrialUpdate #RadioligandTherapy #RadOnc #ESMO25
RENALUT: 177Lu-PSMA-617 in metastatic pre-treated ccRCC - VJOncology
Emmanuel Seront, MD, PhD, Cliniques Universitaires Saint Luc, Brussels, Belgium, discusses the Phase II RENALUT (NCT06783348) of 177Lu-PSMA-617 in patients...
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Charles Geyer, MD, reports #DESTINYBreast05 results in HER2+ early BC. 💊 T-DXd > T-DM1 for iDFS & DFS 🧠 Reduced brain mets risk ⚖️ Manageable safety → potential new SoC 🎥 buff.ly/r3AwOkw #BreastCancer #BCSM #CTSM #TrialUpdate #ImmunoOnc #Immunotherapy #HER2 #ESMO25 @myesmo.bsky.social
DESTINY-Breast05: T-DXd vs T-DM1 in high-risk HER2+ early breast cancer - VJOncology
Charles Geyer, MD, University of Pittsburgh Medical Center, Pittsburgh, PA, discusses results from the Phase III DESTINY-Breast05 trial (NCT04622319), comparing...
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Nima Nabavizadeh, MD, presents #PATHFINDERII data on multi-cancer early detection. 🧬 cfDNA test detects cancer signal & origin 📈 High specificity & PPV ⚕️ Boosted early-stage cancer detection 🎥 buff.ly/LDR0AgW #CancerScreening #Oncology #ESMO25
PATHFINDER II: assessing the efficacy and safety of a MCAD test - VJOncology
Nima Nabavizadeh, MD, Oregon Health & Science University, Portland, OR, discusses the PATHFINDER II study (NCT05155605), evaluating a multi-cancer early...
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Neal Shore, MD, FACS shares final OS data from EMBARK in high-risk BCR prostate cancer. 💊 Enzalutamide + leuprolide ↓ risk of death vs leuprolide alone 📈 Improved progression & skeletal outcomes ✅ Confirms enzalutamide-based therapy as SoC 🎥 buff.ly/LBEmrOa #ProstateCancer #ESMO25 #UroOnc #UroSoMe
EMBARK: final OS results of enzalutamide in hrBCR prostate cancer - VJOncology
Neal Shore, MD, FACS, Carolina Urologic Research Center, Myrtle Beach, SC, discusses final overall survival results from the Phase III...
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Alexandra Drakaki, MD, PhD, discusses FORAGER-1 testing LY3866288 in FGFR3-altered tumors 🧬 200 mg BID = well tolerated 💥 Encouraging antitumor activity in mUC 🧪 Activity seen post-FGFR inhibitor exposure 🎥 buff.ly/ozWqgdG #BladderCancer #Blcsm #UroOnc #UroSoMe #CTSM #TrialUpdate #ESMO25
FORAGER-1: dose optimization of LY3866288 in FGFR3-altered tumors - VJOncology
Alexandra Drakaki, MD, PhD, University of California, Los Angeles, CA, discusses the Phase I FORAGER-1 study (NCT05614739) of LY3866288, a...
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Shigehira Saji, MD, PhD, shares final OS data from EMERALD in 1L HER2+ #BreastCancer. 💊 Eribulin or taxane + trastuzumab + pertuzumab 📈 Median OS >6 years, similar across arms 🧬 PIK3CA = poor prognosis, no impact on treatment effect 🎥 buff.ly/R9sZAVk #BCSM #TrialUpdate #CTSM #ImmunoOnc #ESMO25
EMERALD: eribulin plus dual HER2 blockade in first-line HER2+ breast cancer - VJOncology
Shigehira Saji, MD, PhD, Fukushima Medical University, Fukushima, Japan, comments on discusses final survival results from the EMERALD study (NCT03264547)...
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Andreas Dietz, MD, PhD, discusses the ADRISK Phase IIb trial in adjuvant HNSCC. 💉 Pembrolizumab + chemoradiation ➡️ No sig. EFS/OS gain, but favorable trends ⚖️ Safety consistent; supports further study 🎥 buff.ly/NlJqVv0 #HNSCC #Immunotherapy #Oncology #ESMO25
ADRISK: pembrolizumab plus adjuvant chemoradiation in HNSCC - VJOncology
Andreas Dietz, MD, PhD, University Hospital of Leipzig, Leipzig, Germany, discusses the Phase IIb ADRISK trial (NCT03480672), which evaluated pembrolizumab...
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At #ESMO25, Enrique Grande, MD, presents results from the Phase II DISCUS trial in aUC. 💊 3 vs 6 chemo cycles before avelumab maintenance 📈 Similar OS & PFS 💪 Better QoL & fewer toxicities with 3 cycles 🎥 buff.ly/UjqkfNT @myesmo.bsky.social #BladderCancer #ImmunoOnc #GUcancer #Oncology
DISCUS: comparing 3 vs 6 chemotherapy cycles before avelumab in aUC - VJOncology
Enrique Grande, MD, MD Anderson Cancer Center Madrid, Madrid, Spain, discusses the Phase II DISCUS trial (NCT06892860), which evaluated whether...
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Clara Steiner, MD, presents new transcriptomic findings from COSMIC-313 in #RCC at #ESMO25 🧬 RNA sequencing of baseline tumors 🔍 Distinct gene signatures by metastasis site 🌡️ Pathways: metabolism, hypoxia, EMT 🎥 Watch: buff.ly/dIMvnoC @myesmo.bsky.social #KCSM #CTSM #TrialUpdate #UroOnc #UroSoMe
COSMIC-313: transcriptomic predictors of metastatic sites in RCC - VJOncology
Clara Steiner, MD, Dana-Farber Cancer Institute, Boston, MA & University Hospital Leipzig, Leipzig, Germany, discusses a post-hoc transcriptomic analysis from...
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Alexander Wyatt, DPhil, shares IMvigor011 results of ctDNA-guided adjuvant atezolizumab in high-risk #BladderCancer: 🧬 Atezolizumab improved DFS & OS in ctDNA+ pts 🚫 ctDNA– pts had low recurrence risk ✅ Safety consistent with known profile 🎥 Watch: buff.ly/g35zqx2 @myesmo.bsky.social #ESMO25
IMvigor011: ctDNA-guided adjuvant atezolizumab in MIBC - VJOncology
Alexander Wyatt, DPhil, University of British Columbia, Vancouver, Canada, discusses the Phase III IMvigor011 trial (NCT04660344) of circulating tumor (ctDNA)-guided...
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At #ESMO25, Shigehira Saji shares new MonarchE data on Ki-67 as a biomarker in HR+/HER2– high-risk #BreastCancer: 📊 High Ki-67 = ↑ recurrence risk 💊 Abemaciclib + ET effective across all Ki-67 subgroups ✅ Broad benefit, regardless of Ki-67 change 🎥 Watch: buff.ly/F1mziDY #BCSM #CTSM #TrialUpdate
MonarchE: Ki-67 dynamics and prognostic value in HR+/HER2- breast cancer - VJOncology
Shigehira Saji, MD, PhD, Fukushima Medical University, Fukushima, Japan, discusses the MonarchE trial (NCT03155997) evaluating the prognostic and predictive value...
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At #ESMO25, Scott Tagawa, MD, MS, FACP, discusses the Phase III PSMAddition trial in PSMA-positive mHSPC: 💥 Adding ¹⁷⁷Lu-PSMA-617 to ADT + ARPI improved rPFS 📈 OS trend & manageable safety ✅ No major QoL impact 🎥 Watch: buff.ly/vSBfVPS @myesmo.bsky.social #PCSM #UroOnc #UroSoMe #RadOnc #CTSM
PSMAddition: 177Lu-PSMA-617 plus ADT and ARPI in PSMA-positive mHSPC - VJOncology
Scott Tagawa, MD, MS, FACP, Weill Cornell Medical Center, New York, NY, discusses the Phase III PSMAddition trial (NCT04720157), which...
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At #ESMO25, Clara Steiner, MD, presents 5-year results of CheckMate 274 in MIUC 💊 Adjuvant nivolumab vs placebo after surgery 📈 Sustained DFS, OS & disease-specific survival benefit 🧫 ctDNA-positive pts saw enhanced benefit ✅ No new safety concerns 🎥 Watch: buff.ly/ou4EvLv #UroOnc #UroSoMe #Blcsm
CheckMate 274: 5-year results of adjuvant nivolumab in MIUC - VJOncology
Clara Steiner, MD, Dana-Farber Cancer Institute, Boston, MA & University Hospital Leipzig, Leipzig, Germany, gives an overview of updated 5-year...
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At #ESMO25, Stephanie Graff, MD, addresses key questions in #BreastCancer care. 💊 Updates on CDK4/6 inhibitors 💪 Managing endocrine therapy toxicities 🌍 Global survivorship & trial access insights 🎥 Watch the full session: buff.ly/LdOXB18 #BCSM #Oncology
Ask the Expert: Stephanie Graff answers your breast cancer questions at ESMO 2025 - VJOncology
Stephanie Graff, MD, Brown University Health Cancer Institute, Providence, RI, joins us for an “Ask the Expert” session at ESMO...
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At #ESMO25, Emmanuel Seront discusses the RENALUT trial of ¹⁷⁷Lu-PSMA-617 in metastatic ccRCC 💥 PSMA-targeted radioligand therapy after TKI + ICI progression 🎯 Evaluating response, PFS, OS, & safety 🧠 Imaging-guided treatment w/ added cycles for responders 🎥 buff.ly/sswLUyk #kcms #UroOnc #UroSoME
RENALUT: 177Lu-PSMA-617 in metastatic pre-treated ccRCC - VJOncology
Emmanuel Seront, MD, PhD, Cliniques Universitaires Saint Luc, Brussels, Belgium, discusses the Phase II RENALUT (NCT06783348) of 177Lu-PSMA-617 in patients...
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🎥Prof. Jun Ma of Sun Yat-sen University Cancer Center, Guangzhou, China, discusses sequencing IO and radiotherapy in nasopharyngeal carcinoma: ➡️ buff.ly/K24ba3d ⬅️ #ASCO25 #ImmunOnc #hncSM
Sequencing IO and radiotherapy in nasopharyngeal carcinoma - VJOncology
Jun Ma, MD, Sun Yat-sen University Cancer Center, Guangzhou, China, comments on the potential benefits of integrating PD-1 immunotherapy (IO)...
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🎥Cecile Riviere-Cazaux, PhD, highlights the emerging role cfDNA as novel biomarkers in neuro-oncology, noting their ability to detect molecularly defined biomarkers and monitor treatment response: ➡️ buff.ly/xCKCsRY #BTSM #Oncology
The future of CSF liquid biopsies in precision medicine for brain tumors - VJOncology
Cecile Riviere-Cazaux, PhD, Mayo Clinic, Rochester, MN, highlights the emerging role cell-free DNA (cfDNA) as novel biomarkers in neuro-oncology, highlighting...
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🎥Prof. Jun Ma of Sun Yat-sen University Cancer Center, Guangzhou, China, discusses current immunotherapy approaches in nasopharyngeal carcinoma: ➡️ buff.ly/egOS3ia #ASCO25 #ImmunOnc #hncSM
The future of immunotherapy in nasopharyngeal carcinoma beyond PD-1 - VJOncology
Jun Ma, MD, Sun Yat-sen University Cancer Center, Guangzhou, China, discusses current immunotherapy approaches in nasopharyngeal carcinoma. There is a...
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🎥Christina Fotopoulou, MD, PhD, of @imperialcollegeldn.bsky.social highlights accessibility as a key barrier to optimal surgical care in advanced #OvarianCancer: Watch here➡️ buff.ly/yLzNHzG #ESMOGynae25 #GynOnc #GyncSM #CTSM #TrialUpdate #SurgOnc
Hurdles to providing equitable surgical care for ovarian cancer - VJOncology
Christina Fotopoulou, MD, PhD, Imperial College London, London, UK, emphasizes the importance of accessibility as a major barrier in providing...
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🎥Aslı Doğa Munzur, BSc, discusses clonal hematopoiesis (CH) as a potential biomarker in #mCRPC ⭐Ongoing work aims to define CH’s role in predicting blood disorder risk & guiding patient selection: ➡️https://buff.ly/Y9FKoJW @ascocancer.bsky.social #ASCO25 #UroOnc #UroSoMe #PCSM
Clonal hematopoiesis monitoring as a future biomarker in mCRPC - VJOncology
Aslı Doğa Munzur, BSc, Vancouver Prostate Centre, Vancouver, Canada, speaks on the potential of clonal hematopoiesis (CH) as a biomarker...
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🎥Fabrice André, MD, PhD, argues against continuing the same CDK4/6 inhibitor after progression in HR+/HER2– #BreastCancer Watch here➡️https://buff.ly/6Uqux4A @myesmo.bsky.social #ESMOBreast25 #BCSM
Post-progression CDK4/6 inhibitors in breast cancer: a failing strategy? - VJOncology
Fabrice André, MD, PhD, Gustave Roussy, Villejuif, France, shares his rationale against the continuation of CDK4/6 inhibitors following disease progression...
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⭐Christina Fotopoulou, MD, PhD, reports TRUST: primary debulking surgery improved PFS in advanced ovarian cancer, though OS was similar across arms: 🎥 buff.ly/DEDNtYW #ESMOGynae25 #GynOnc #GyncSM #CTSM #TrialUpdate #SurgOnc
TRUST: optimal timing of surgical therapy in advanced ovarian cancer - VJOncology
Christina Fotopoulou, MD, PhD, Imperial College London, London, UK, discusses the TRUST study (NCT02828618), a prospective randomized trial on the...
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⭐ Jason Mouabbi, MD, of @mdanderson.bsky.social, shares an overview of key studies in breast cancer presented at #ASCO25: 🎥 buff.ly/0IeuM2Z @ascocancer.bsky.social #BCSM #BreastCancer #CTSM #TrialUpdate #ImmunoOnc
ASCO 2025 highlights in breast cancer: ASCENT-04, SERENA-6, and more - VJOncology
Jason Mouabbi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, gives an overview of key studies in...
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⭐ Swati Kulkarni, MD, discusses the PROMISE study, assessing presurgical use of conjugated CE/BZA in postmenopausal women with ER-positive DCIS: 🎥 buff.ly/FJvSAAR @ascocancer.bsky.social #ASCO25 #BreastCancer #CTSM #TrialUpadte #SurgOnc
PROMISE: CE/BZA in postmenopausal, ER+ ductal carcinoma in situ - VJOncology
Swati Kulkarni, MD, Northwestern University Feinberg School of Medicine, Chicago, IL, discusses the Phase II PROMISE study (NCT02694809), which assesses...
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⭐ Fabrice André, MD, PhD, shares KEYNOTE-756 results: ➡️ Adding pembrolizumab to neoadjuvant chemo improved pCR in high-risk ER+/HER2- breast cancer. EFS data pending... 🎥 buff.ly/0R25Yjb #ESMOBreast25 #BreastCancer #BCSM #CTSM #TrialUpdate #ImmunoOnc
KEYNOTE-756: pembrolizumab & neoadjuvant chemotherapy in ER+/HER2- breast cancer - VJOncology
Fabrice André, MD, PhD, Gustave Roussy, Villejuif, France, discusses the Phase III KEYNOTE-756 study (NCT03725059) of pembrolizumab with neoadjuvant chemotherapy...
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⭐ Felix Hilpert, MD, stresses that age/frailty shouldn’t preclude ovarian cancer therapy: chemo & surgery can extend survival in older pts: 🎥 buff.ly/MUxPkAI #ESMOGynae25 #GynOnc #GyncSM
Unmet needs in treating ovarian cancer in geriatric patients - VJOncology
Felix Hilpert, MD, Krankenhaus Jerusalem, Hamburg, Germany, gives an overview of treatment gaps in elderly and frail patients with ovarian...
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⭐ Yue Che, MD, shares RAISN trial: ICG-guided sentinel node biopsy is feasible & well tolerated in stage I testicular cancer, aiming to reduce chemo use: 🎥 buff.ly/kF09jHH #EAU25 #UroOnc #UroSoMe #CTSM #TrialUpdate #TSCsm
RAISN: indocyanine green-guided lymph node dissection in testicular cancer - VJOncology
Yue Che, MD, University Hospital of Duesseldorf, Düsseldorf, Germany, discusses the evolving role of retroperitoneal lymph node dissection and therapy...
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