Vincent Nicholson
@vnchlsn.bsky.social
Graduate Student in the Holehouse Lab at Washington University in St. Louis. Posting mainly about science and occasionally about hockey and politics. Professional Contact: vincentn@wustl.edu Linktree: https://linktr.ee/vnchsln
I'm super excited to share the most recent work from my time in the lab of Thomas Boothby at the University of Wyoming, in collaboration with @shaharsu.bsky.social! Read the paper here: www.cell.com/action/showP...
cell.com
More exciting news from the Center for Biomolecular Condensates at WashU McKelvey School of Engineering - Discoveries through technological innovations and conceptual leaps engineering.washu.edu/news/2025/Un...
Uncovering the electrochemistry of condensates
Researchers at Washington University in St. Louis are discovering the electrochemical properties of biomolecular condensates which could help in development of cancer or ALS treatments.
engineering.washu.edu
“NO SCIENCE, NO BEER” is potentially the most Fort Collins, Colorado protest chant of all time
When universities cut their budgets, research and the local economies suffer 🧪: www.forbes.com/sites/michae...
As Feds Slash Funds, Research Universities Start To Trim Their Budgets
Amid worries about the Trump administration’s plans for research funding and higher education, major research universities have begun to tighten their budget belts.
forbes.com
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...
Very happy to announce that my first-author paper, "LEA_4 motifs function alone and in conjunction with synergistic cosolutes to protect a labile enzyme during desiccation", is now published in Protein Science!! onlinelibrary.wiley.com/doi/10.1002/...
LEA_4 motifs function alone and in conjunction with synergistic cosolutes to protect a labile enzyme during desiccation
Organisms from all kingdoms of life depend on Late Embryogenesis Abundant (LEA) proteins to survive desiccation. LEA proteins are divided into broad families distinguished by the presence of family-s...
onlinelibrary.wiley.com
One of the highest compliments on scientific work is: “certainly someone must have done that earlier”
Our paper is out! To identify new protectant proteins we expressed tardigrade genes in bacteria and screened for those that could improve desiccation survival. It was a fun (and effective) screening approach. Check it out and see what we found! www.sciencedirect.com/science/arti...
A bacterial expression cloning screen reveals single-stranded DNA-binding proteins as potent desicco-protectants
Desiccation kills most cells. Some proteins have been identified to help certain cells survive desiccation, but many protein protectants are likely to…
sciencedirect.com
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler. Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations. pubs.acs.org/doi/10.1021/...
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations
It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facili...
pubs.acs.org
Breaking news: President-elect Donald Trump announced he had selected Robert F. Kennedy Jr. to run the Department of Health and Human Services, the agency responsible for administering millions of Americans’ health insurance and responding to infectious-disease outbreaks.
Live updates: Trump selects vaccine skeptic Robert F. Kennedy Jr. to lead HHS
Get the latest news on the transition to the new administration of President-elect Donald Trump and a new Congress.
washingtonpost.com