Wake Forest Section on Infectious Diseases

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Learn more about the section at https://school.wakehealth.edu/departments/internal-medicine/infectious-diseases and wakeforestid.com #idsky #medsky #episky Not an official account of Wake Forest University School of Medicine.

Drs. Luis Barroso & Julia Cook from the Section on Infectious Diseases present Most Influential Papers in Section on Infectious Diseases: A Biennial Update - a review of the landmark studies shaping ID practice over the past two years. DoxyPEP, Dalbavancin, Long Acting Injectables, and more!

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🦠💉 Groundbreaking work by Dr. Wierzba & team on ETVAX, the first vaccine to protect children from deadly E. coli, reduced severe diarrhea by up to 68% in infants! Up to 42,000 young lives lost yearly. www.scientificamerican.com/article/firs...

First-of-its-kind vaccine protects children from deadly intestinal infections

ETVAX is the first vaccine that offers significant protection against pathogenic E. coli in children

scientificamerican.com

New publication! Congrats to Michael DeWitt and former Pennell Fellow Seth Addo on their paper, “Occurrence of Tick‑Borne Pathogens in Rhipicephalus sanguineus s.l. From Domestic Dogs in Kumasi, Ghana.” 🔗 buff.ly/QG7rEwN #idsky #wfuresearch #onehealth #globalhealth.

Occurrence of Tick-Borne Pathogens in Rhipicephalus sanguineus Sensu Lato From Domestic Dogs in Kumasi, Ghana

Tick-borne pathogens, transmitted by ticks, infect humans and animals worldwide. The brown dog tick, Rhipicephalus sanguineus sensu lato, is a significant vector of a number of pathogens, including Ehrlichia canis, Rickettsia and Anaplasma species. In Ghana, there is limited information on the pathogens carried by Rh. sanguineus s.l. As such, Rh. sanguineus ticks taken from domestic dogs in Kumasi were screened for tick-borne pathogens, including Coxiella burnetii, Rickettsia, Babesia, Theileria, Anaplasma, Ehrlichia and Hepatozoon species. A total of 204 ticks collected from 56 infested dogs were morphologically identified as Rh. sanguineus s.l. From the 88 pools screened, 36 (40.9%) were positive for pathogen DNA. The pathogens identified were Rickettsia africae (5 pools), Ehrlichia canis (10 pools) and uncultured Anaplasma sp. (21 pools) with maximum likelihood estimates as 2.48% (95% CI: 0.93, 5.38%), 5.22% (95% CI: 2.69, 9.15%) and 11.20% (95% CI: 7.32, 16.29%), respectively. There was no association between the detection of a pathogen and the tick sex or dog breed, age or sex. This study provides important baseline data on the circulation of tick-borne pathogens in Rh. sanguineus s.l. ticks in Kumasi, with implications for both veterinary and human health. The presence of uncultured Anaplasma sp. suggests a wider diversity of tick-borne bacteria with unknown pathogenicity. There is a need for integrated tick control, improved diagnosis and additional epidemiological studies to mitigate the impact of tick-borne diseases in Ghana.

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