How it started: Quantify. Calculate. Dilute. Pool. Hope. How it's going: Normalize. Pool. Sequence. Replacing manual quantify-&-dilute workflows with rapid normalization, EquiPlex™ helps reduce opportunities for error while making it easier to achieve balanced sequencing pools

Choosing a library amplification mix used to mean compromise. Until now. Equinox Prime delivers high-fidelity amplification with excellent yield, GC coverage uniformity, PCR efficiency, & reduced polymerase slippage. Learn more in the comments. #NoCompromise #NGS #Genomics

Let’s #ThrowbackThursday to #AGBT2026! Our collaboration with @atlasxomics.bsky.social , NYU Langone Health, & Ultima Genomics combined spatial ATAC-TAPS+ to map chromatin accessibility + DNA methylation in one tissue section. Full poster in the comments. 👇

That’s a wrap on #ESHG2026! Great week in Gothenburg discussing TAPS+, EquiPlex, & Equinox Prime with the human genetics community. Thanks to those who joined our workshop, visited our posters, & stopped by Booth 256. Link in comments for workshop & poster copies! #Genomics #NGS

Don't let your library amplification mix have you slippin’. Polymerase slippage creates false indels in homopolymers & repetitive regions - especially problematic for MSI profiling. Equinox Prime reduces indel errors so repeat lengths better reflect biological reality. #SkipTheSlip #NGS #Genomics

Heading to #ESHG2026? Join us in Gothenburg! View our posters on methylation sequencing & PCR-free WGS Sunday, then attend our workshop Monday: "From Multiomics to Multiplexing." Visit Booth 256 for details, posters & more: watchmakergenomics.com/events/eshg2026

You've heard the normalization promises before. We built EquiPlex differently. No template destruction. No library jackpotting. No dilution calculations. No variable-volume pipetting. Just fast, simple normalization that fits existing #NGS workflows. Data in comments. #Genomics

Finally! No more trade-offs in library amplification. 🎉 Equinox Prime is here. ✔ Up to 55% lower polymerase error rates ✔ Reduced slippage for improved indel calling ✔ Uniform GC coverage ✔ Fewer PCR cycles, higher yield Learn more: link in comments. #NGS #Genomics

As sequencing workflows scale, bottlenecks in normalization, pooling, & amplification can impact efficiency & data quality. At #ESHG2026, we're unveiling EquiPlex & Equinox Prime. Visit Booth 256 & join our June 15 workshop to learn more. Full announcement: link in comments.

👋 Watchmaker is at #SEASR & ready to chat about how our #NGS solutions are helping labs streamline workflows, improve accuracy, & get more out of every sample. Stop by & chat about your sequencing challenges, or to see how Watchmaker can help you get more out of every sample. 🧬

Join Watchmaker at #ESHG2026 for a 90-minute workshop with Dr. Laura Glaser (MGZ) & Dr. Pieter Mestdagh (CellCarta) on improving sequencing accuracy & scalability. We’ll also unveil Equinox Prime & EquiPlex Normalization. Visit us at Booth 256! www.watchmakergenomics.com/events/eshg2...

For the 4th year in a row, our Watchmakers teamed up with #HabitatForHumanity to help build a home for a family in need. 🏡🔨 From painting & nailing to sealing gaps, the team put their skills to work, & learned that “measure twice, cut once” is easier said than done. 😅

Data isn’t the only thing our teams have been generating lately. 😅 Across Boulder & Cape Town, Watchmakers came together to support survivors, vulnerable children, & local communities through donation drives, food support, & Slipper Day giving. #WatchmakerGivesBack

FFPE & cfDNA samples keep sequencing teams humble 😅 Low input. Damage. Artifacts. Coverage headaches. But difficult samples shouldn’t mean compromised data. Watchmaker’s high-efficiency #NGS library prep solutions help maximize usable insights from challenging samples. 🔑🧬

Why are developers switching from LAMP to RPA for point-of-care testing? RPA offers simpler 2-primer design, lower temps (~40°C), results in <10 min, strong inhibitor tolerance, & easier multiplexing - even from crude samples. More in the comments. #MolecularDiagnostics #RPA

We’re headed to Santa Fe for the 20th Annual #SFAFMeeting, a uniquely technical genomics meeting built around real discussion between academia, industry, & government. Excited to talk sequencing performance, scaling workflows, & multiomic data. If you’re there, Sara & Frankie would love to connect!

What’s it like to work at Watchmaker? Fast-moving, collaborative, and focused on solving hard problems in genomics. We’re hiring curious, driven people who want to build meaningful things alongside a smart, supportive team. Open roles in the comments. #Hiring

Cancer research is built on difficult samples: aged FFPE tissue, ultra-low input liquid biopsies, & hard-to-recover signals. During Cancer Research Month, we’re recognizing the researchers turning challenging samples into meaningful data & progress. #CancerResearchMonth

Missed #ESCMIDGlobal2026? Catch Curtis on-demand as he shares how new RT-qPCR/qPCR chemistry enables rapid, extraction-free pathogen detection from crude samples with strong inhibitor tolerance, fast cycling, & reliable performance. 🎥 Link in comments

At Watchmaker, great chemistry is just the start - scaling it is where it counts. Our Process Development team ensures enzymes, buffers, & kits perform consistently from bench to production, delivering reliable supply & fewer surprises. #ScaleUpSquad #NGS #Genomics

🎸 We don’t need no degradation. Hey! Bisulfite! Leave those bases alone. TAPS+ delivers the full spectrum from one library: SNVs, indels, CNVs, and methylation. No harsh chemistry. No DNA damage. Just complete data. 🌈 🔬 See more: Link in comments #Epigenomics #TAPS #Genomics

🌎 This Earth Day, WOUCHEE took “spring cleaning” outdoors. The Boulder team spent the afternoon cleaning up a bike path & along with the standard litter haul, we also managed to pull a rug out of the river, which was not on anyone’s bingo card. 😅 #EarthDay #CleanUpCrew

RPA Fast Facts, Pt 2: How does #RPA actually work? In this video, take a closer look at the underlying chemistry behind recombinase polymerase amplification, including how exponential amplification occurs without thermal cycling. For more details, click the link in the comments

We’re off to San Diego for #AACR2026! Excited to connect with oncology community & share NGS innovation in tumor biology & biomarker discovery. Featuring TAPS+, Equinox Prime, & EquiPlex. Check out our posters on Mon - #1951 at 9AM & #3213 at 2PM #CancerResearch #Epigenetics

Introducing our RPA Fast Facts video series. We’re breaking down why recombinase polymerase amplification (RPA) is gaining traction for point-of-care & rapid testing. First: why developers are moving from LAMP to RPA. More to come - link in comments. #MolecularDiagnostics #RPA

Skip the cleanup. Keep the signal. Introducing Stellar RT-qPCR & qPCR Kits - built for inhibitor tolerance, enabling direct amplification from crude samples without sacrificing performance. Faster results, high sensitivity, & less prep. #MolecularDiagnostics #InfectiousDisease

High-performing chemistries don’t happen by accident. Our R&D Applications Development Group bridges innovation, customer needs, & commercialization, advancing workflows from concept to launch. Turning great enzyme design into solutions that work. #AppsIsAwesome #NGS #Genomics

We’re headed to #ESCMIDGlobal2026 in Munich & excited to connect with the clinical microbiology community. Introducing a new qPCR/RT-qPCR chemistry for fast, extraction-free amplification from tough samples. 📅 Sun, April 19 | 10:30–10:50 AM 📍 Booth G37 #MolecularDiagnostics

#ABRF2026, you delivered. Great conversations, excellent sessions, & top-tier karaoke 🎤 Always a highlight to spend time with such an engaged & collaborative community. Miss our session, or didn't get to stop by the booth? Check out our ABRF page in the comments. Until next time!

ABRF friends, see you tomorrow! ☀️🥂 Join our breakfast workshop: From Multiomics to Multiplexing 7:45–8:45 AM | Room 411–412 TAPS+, EquiPlex, and practical ways to scale genomics cores without sacrificing efficiency. Mimosas are included. See us in Booth 304 after!