Xiaoyun Ding

@xyding.bsky.social

Glial biologist studying myelin and neuron-glia interactions at Baylor College of Medicine NEI K99 Fellow | Leading Edge Fellow

Happy to share our newest preprint! Using proximity proteomics, we identify Palm2 as a shared organizer of specialized membrane domains, with distinct regulation and functions in neurons vs oligodendrocytes. I’ll present a poster at #cshlglia this week—looking forward to discussions and feedback!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 4w ago

Paralemmin 2 is a shared, alternatively-spliced regulator of axon initial segments and paranodal junctions in oligodendrocytes https://www.biorxiv.org/content/10.64898/2026.08.18.745582v1

And the amazing @jiaxingli.bsky.social is hiring a postdoc! Reach out if you love glia, development, or watching cells dance. He’s one of the coolest people to share your passion for science with. Super talented and meticulous, yet incredibly humble and easygoing. #neurojob #academicjob

Zebrafish Rock!@zebrafishrock.bsky.social · 6mo ago

Oligodendrocyte precursor cell in the spinal cord of a transgenic zebrafish larva. Credit to @jiaxingli.bsky.social. #ZebrafishZunday 🧪

Excited to share that I’ve been awarded the K99 from NEI to support my work on the mechanisms of axon-glia interactions. Grateful to my mentors, colleagues, friends, and family for their support. It takes a village! You’ve all shaped the scientist I am today. 🔬Pictured here: developing nodes.

Bild

Fluorescence Friday - DNA-PAINT imaging of axon initial segment TRIM46 ('cyan') and bIV spectrin ('red') by the incomparable Allison Melton in my laboratory. Just spectacular!

Bild

The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!

A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment - Nature Communications

The existence of phosphatases specialized in regulating the axon initial segment (AIS) was unclear. Here, the authors show that a PP2A-B55 subunit is selectively enriched at the AIS and contributes to...

nature.com

In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me! Hope this tool helps more people see it too.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 11mo ago

OASIS: in vivo AAV-mediated transduction and genome editing of adult oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.10.20.683551v1