Ceperognastat and the Limits of Tau Biomarker Translation

Tau PET tracks Alzheimer’s disease better than amyloid PET, but tracking disease is not the same as proving what will rescue the brain.

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Why Aren’t We Giving APOE2 to APOE4 Carriers?

APOE2 may protect the aging brain, but it is not a simple genetic upgrade.

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Protein Maxing Helps Muscle. But Does it Help Aging?

The Protein Longevity Paradox

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Exercise, Sitting, and APOE4

Why movement may matter most before symptoms begin — and what to do now.

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P-tau217 and the Search for a Goldilocks Window in Alzheimer Prevention Trials

What a Major New Study Says About an Alzheimer’s Blood Test, and What It Doesn’t

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A Reading of the MIND, FINGER, and US POINTER lifestyle interventions for AD

Progress, Missed Opportunities and Why Lifestyle Trials for Alzheimer’s Are So Hard to Get Right

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Are Omega-3 Supplements Actually Good for Your Brain?

nytimes.com

How to avoid dementia — what the science really says

Ambitious studies have been examining the protective effects of diet, exercise and socializing — with surprising results.

nature.com

Fish Oil Supplements Failed to Prevent or Slow Cognitive Decline in Trial

A placebo-controlled trial put fish oil supplements to the test. Over two years, the supplements failed to slow cognitive decline in adults.

beingpatient.com

How to Read A Study

Before You Believe the Headline

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Beyond Omega-3 supplements: What PreventE4 Taught Us About Omega-3s and the Brain

Alzheimer’s prevention may depend on how the brain metabolizes omega-3s.

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Of Mice and Men: The Rapamycin Problem in Alzheimer’s Prevention

Insights from tissue specific immune aging biomarkers

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Alzheimer’s Inflammation: Treating a Fire We Still Can’t Measure

The MINDFuL trial: A Case Study in the Missing Inflammation Biomarker

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Taurine, ALZ-801, and the Long Road to an Alzheimer’s Drug

Why Alzheimer’s science demands both hope and caution

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While You Were Sleeping

How Your Brain Cleans Itself -- and What It Means for Alzheimer's

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Are the New Alzheimer's Drugs Really "Disease-Modifying"?

What the evidence supports about lecanemab and donanemab — and what it does not.

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What a New Study Gets Wrong About Fish Oil

And why association is not causation

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Meet the Brain's Immune System — and Why It's the Next Big Bet Against Alzheimer's"

A drug designed to supercharge the brain's immune cells just failed its biggest clinical test; but all is not lost.

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Use It or Lose It

How mental activity affects the risk of dementia

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The Vascular Side of Alzheimer's: A New Hypothesis for Why the Brain Bleeds

A fresh Perspective on vascular inflammation in AD

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What the World's Oldest Person Teaches Us About Inflammation and Longevity

No single diet, supplement, or habit made her 117.

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When Your Brain's Immune System Burns Out: A New Way to Think About Alzheimer's Disease

What if Alzheimer's isn't just about the buildup of toxic proteins — but about the immune cells that were supposed to clean them up, and why they eventually stop doing their job?

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Red Meat, APOE4, and the Limits of Observational Nutrition Science

Observational studies can drive you nuts!

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SPARK (Supporting Progress in Alzheimer's Research and Knowledge) is a program that connects participants with research opportunities and helps advance discoveries in Alzheimer's disease and dementia. Your de-identified survey responses also contribute to research, ensuring your privacy while enabling researchers to better understand the factors that influence brain health.

redcap.link

The Amyloid Hypothesis of Alzheimer's Disease: What is Validated, What is Missed, and What Comes Next

One of the most debated hypotheses in modern medicine

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Hormone Replacement Therapy, Brain Health, and APOE4

Understanding the benefits, risks, and unanswered questions surrounding hormone therapy and cognitive aging.

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To Statin or Not To Statin for Alzheimer's?

Why the best case for statins in APOE4 is vascular, not “Alzheimer’s treatment”

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cPLA2 and the Synapse

New human data on an inflammatory enzyme linked to cognitive impairment in Alzheimer's disease

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Ketosis, weight loss, and the APOE ε4 brain

A 70-year-old man came for a second opinion on optimizing brain health.

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