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Yildiz Tasdan

@yildiztasdan.bsky.social

Postdoctoral researcher in medicinal chemistry and drug discovery

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Yildiz Tasdan@yildiztasdan.bsky.social · last yr.

Our recent preprint, “Exploiting a Cryptic Pocket in DsbA Through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening,” is now available on ChemRxiv. chemrxiv.org/engage/chemr...

Exploiting a Cryptic Pocket in DsbA Through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening

Antibacterial resistance is a major global health problem, causing an increasing number of deaths worldwide. DsbA, a bacterial oxidoreductase enzyme, is pivotal for the correct folding and activity of...

chemrxiv.org

Scott Bagley@bagphos.bsky.social · 2y ago

#ChemSky cleanser The annual #JMedChem article on Synthetic Approaches to the New Drugs Approved during 2023 is out now with industry authors from Takeda, Crosswalk, Merck and Pfizer A great reference for anyone interested in the synthetic chemistry we use in pharma

Synthetic Approaches to the New Drugs Approved during 2023

This review is the next installment of an annual series that discusses the synthetic routes to access 28 small molecule drugs that were approved worldwide in 2023. A brief description of each drug’s mechanism of action, the history of its discovery and development, and the synthetic approaches published in primary or patent literature that were most likely used for clinical studies or development are included. Synthetic chemistry, used to convert complex intermediates to active compounds or build a new drug from basic building block chemicals, is critical to delivery of new drugs and treatments for disease to patients.

pubs.acs.org

Saloni@scientificdiscovery.dev · 2y ago

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!

A timeline titled "The Golden Age of Antibiotics" shows when each antibiotic drug class was first available for medical use, with example antibiotics labeled. Classes are color-coded by their source: actinomycetes, other bacteria, fungi, or synthetic. Milestones include the first antibiotics (arsphenamines in 1910), as well as the discovery of many actinomycetes-derived antibiotics, such as streptomycin, and sulfonamides, penicillins, and tetracyclines. Data: Hutchings, Truman, Wilkinson (2019). Created by Saloni Dattani for Our World in Data.