1/n: 2nd preprint this week: www.biorxiv.org/content/10.1.... We functionalized a G(13)PCR P2RY8 that keeps germinal center (GC) B cells confined. Taylor LaFlam performed saturation mutagenesis, Aashish Manglik's lab solved the structure, and collaboration with Cyster lab validated variant effects.

Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8

Missense variants can have pleiotropic effects on protein function and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G-protein-coupled re...

biorxiv.org

New preprint from the lab. Single-cell CITE-seq of 1.5M PBMCs identifies two immunological subtypes of Sjögren’s disease, the second most common autoimmune disease after rheumatoid arthritis: www.biorxiv.org/content/10.1.... 1/n

Single-cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease

Sjögren's disease (SjD) is a heterogeneous autoimmune disorder with significant clinical and molecular diversity. While anti-SSA antibodies serve as a hallmark serological biomarker, nearly half of pa...

biorxiv.org

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Come to UCSF and work with Chris. He’s got some really cool tech that could fundamentally change the way we study and control gene regulation. And oh yeah, this is my first post!

Chris Hsiung@chrishsiung.bsky.social · 2y ago

My lab at UCSF (hsiunglab.org) is looking to recruit multiple postdocs across the spectrum of wet/dry lab interests to contribute to our research in synthetic gene regulation, combinatorial genetics, and tissue biology (including liver biology and immuno-oncology).