🧬 New preprint! We present an All by All analysis in All of Us: common and rare variant association testing across 392,030 whole genomes and 3,602 phenotypes. 1.337 trillion tests, ~50k significant signals, all publicly browseable. www.medrxiv.org/content/10.6...

Systematic common and rare variant association testing in 392,030 whole genomes in All of Us

Large-scale genome-wide association studies (GWAS) and rare variant association studies (RVAS) from population biobanks provide valuable resources for gene discovery in complex human traits. We presen...

medrxiv.org

🎉New preprint: Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk. We evaluate disease risk along 2 complementary axes: • how genetic liability is represented • the social context in which it is expressed

medRxivpreprint@medrxivpreprint.bsky.social · 4mo ago

Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk https://www.medrxiv.org/content/10.64898/2026.04.16.26351039v1