Yan Leyfman, MD
@yleyfman.bsky.social
Physician | Executive Director & Host MedNews Week | Medical Correspondent | Conference Director | Journal Editor | Educator | Research #Oncology #COVID19 #Immunotherapy #celltherapy #tcellrx #CART #bmtsm #MedSKY #ONCSKY | About Me: http://nyti.ms/2VG3gUK
Could gene therapy someday replace morphine? In the newest episode of The Translational Edge, we explore one of the boldest ideas in modern medicine with Shuf: reprogramming pain itself. This one genuinely feels like a glimpse into the future. Watch here: www.shuf.ai/episode-play...
Shuf.ai
Shuf turns any medical content into a new format with AI so that you can increase your audience
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Excited to launch the 1st episode of the MedNews Week × OncoDaily partnership — built around one idea: global oncology education without borders 🌍 Tune in: lnkd.in/gUyXam9B
Precision at the Core: Advancing Nasopharyngeal Carcinoma Care with Proton Beam Therapy | Episode 1
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
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CAR-T therapy has transformed oncology—but toxicity remains its biggest limitation. In Episode 6 of The Translational Edge, we break down one of the most important questions in the field today: Can we push efficacy further without breaking safety?
Shuf.ai
Shuf turns any medical content into a new format with AI so that you can increase your audience
shuf.ai
Thank you to Cancer Network for the feature. Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease Gene editing has moved from concept to clinic. By leveraging CRISPR to reactivate fetal hemoglobin, we’re no longer just managing SCD—we’re aiming to rewrite its biology.
Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease | CancerNetwork
The RUBY trial demonstrates that disrupting the BCL11A binding site in the γ-globin promoters can normalize hemoglobin in severe sickle cell disease.
cancernetwork.com
Thank you to Cancer Network for highlighting: Rethinking Dual Targeting, Durability After CAR-T in Non-Hodgkin Lymphoma CAR T works—but not for everyone.
Rethinking Dual Targeting, Durability After CAR-T in Non-Hodgkin Lymphoma | CancerNetwork
The next frontier is not only building constructs that reduce one mechanism of relapse, but understanding why antigen-positive failures still occur.
cancernetwork.com
Episode 5 of The Translational Edge With Yan Leyfman on Exercise in Cancer Care - Jeremy Bellaiche @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Jeremy Bellaiche: Episode 5 of The Translational Edge With Yan Leyfman on Exercise in Cancer Care - OncoDaily
Jeremy Bellaiche: Episode 5 of The Translational Edge With Yan Leyfman on Exercise in Cancer Care / cancer, Jeremy Bellaiche, OncoDaily, Oncology, The
oncodaily.com
Exercise isn’t just supportive care anymore—it’s becoming therapeutic. In the latest episode of The Translational Edge, we explore how exercise is quietly reshaping cancer care—impacting outcomes, biology, and survivorship in ways we’re only beginning to understand.
Thank you to Cancer Network for highlighting: Reprogramming T Cells: The Promise of In Vivo Site-Specific CAR Engineering CAR T therapy—without the lab. A single infusion. Precise genome integration. T cells engineered in vivo. This is how we scale cellular therapy.
Reprogramming T Cells: The Promise of In Vivo Site-Specific CAR Engineering | CancerNetwork
A landmark Nature study demonstrates targeted CRISPR-based CAR transgene integration in living patients' T cells without ex vivo manufacturing.
cancernetwork.com
Thank you to Cancer Network for highlighting my latest piece: When the World Stopped: A Lesson in Strength and Second Chances A reflection on resilience, perspective, and what oncology teaches us when time stands still. www.cancernetwork.com/view/when-th...
When the World Stopped: A Lesson in Strength and Second Chances | CancerNetwork
Yan Leyfman, MD, reflected on resilience and hope in the face of cancer, recounting a 37-year-old diagnosed with stage IV colorectal cancer followed by HIV.
cancernetwork.com
MedNews Week is proud to announce our partnership with OncoDaily. This collaboration marks an exciting step forward as we continue to expand our platform, amplify our mission, and elevate the voices shaping the future of oncology and medicine worldwide.
Honored to be included in this outstanding group of innovators. It is especially meaningful to be recognized alongside colleagues and mentors who have helped shape the next generation of oncology. x.com/HemOncToday/...
x.com
Today we celebrate the extraordinary women shaping the future of medicine, science, and global education. At MedNews Week, we’ve had the privilege of learning from and collaborating with an incredible community of women leaders —
🎙️ Big News for The Translational Edge Podcast I’m excited to share that The Translational Edge Podcast is now officially available on Spotify and Apple Podcasts, in partnership with Shuf.
Grateful for the opportunity to present 2 oral presentations today to more than 160 attendees at the MSKCC Global Health Equity Conference. The questions were thoughtful, challenging, and exactly what moves work forward. That kind of engagement is why academic medicine matters.
Clinicians Must Shape How AI Impacts Patient Care - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Yan Leyfman: Clinicians Must Shape How AI Impacts Patient Care - OncoDaily
Yan Leyfman: Clinicians Must Shape How AI Impacts Patient Care / AI, cancer, OncoDaily, Oncology, Yan Leyfman
oncodaily.com
In this month’s ONCOLOGY, I write about presence, empathy, and the power of staying with our patients when language falls short. Because sometimes the most meaningful care is simply being there. Honored to share this reflection with CancerNetwork. www.cancernetwork.com/view/when-wo...
When Words Fall Short: A Lesson in Silence and Compassion | CancerNetwork
This section aims to enhance provider empathy, mitigate burnout, and center the patient’s lived experience within the rigorous framework of medical science.
cancernetwork.com
Seeing Trainees Move from Learners to Published Authors - Yan Leyfman(@yleyfman.bsky.social) oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Yan Leyfman: Seeing Trainees Move from Learners to Published Authors - OncoDaily
Yan Leyfman: Seeing Trainees Move from Learners to Published Authors / Ariana Pelosci, cancer, Chandler Park, Ishan Paduvagere, Jenna Ghazal, MedNews Week,
oncodaily.com
Why ASCT Remains Foundational Amid Modern Myeloma Advances - Yan Leyfman(@yleyfman.bsky.social) oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Yan Leyfman: Why ASCT Remains Foundational Amid Modern Myeloma Advances - OncoDaily
Yan Leyfman: Why ASCT Remains Foundational Amid Modern Myeloma Advances / ASCT, cancer, Chandler H Park, Ishan Paduvagere, Jenna Ghazal, multiple myeloma,
oncodaily.com
On World Cancer Day, honored to share my story with Oncology Times. What began as childhood tragedy became a lifelong calling in oncology—rooted in empathy, service, and healing. Grateful for the platform and the chance to reflect. 🎧 Listen here: ow.ly/yj8t50Y8TE8
Very excited to present these abstracts at the 2026 Tandem Meeting 🌍 Forever grateful to my mentors Dr. Bonilla and Dr. Park for their support and guidance 🙏, and to an incredible team of co-authors it was a pleasure to work with on these important projects 💡🤝.
Survey for Real-World Insights on AI Use in Medicine - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Yan Leyfman: Survey for Real-World Insights on AI Use in Medicine - OncoDaily
Yan Leyfman: Survey for Real-World Insights on AI Use in Medicine / cancer, OncoDaily, Oncology, Yan Leyfman
oncodaily.com
📣How are you actually using AI in practice?📣 We’re running a very short, anonymous survey (⏱️ 5 minutes) looking at real-world AI use in medicine — from documentation to clinical decision-making. #AIinMedicine #DigitalHealth #AIinHealthcare #ClinicalPractice #PhysicianVoices
The Competence - Confidence Gap in AI Oncology [Long Version]
Thank you for participating in this survey on the use of artificial intelligence (AI) in oncology practice. This anonymous survey explores how oncology clinicians interact with different AI tools in ...
docs.google.com
🧠⚕️ Beyond board exams: evaluating AI for real-world medicine Large language models can ace medical licensing exams—but that says little about how they perform in day-to-day clinical practice. Enter MedHELM, a new framework designed to evaluate medical AI where it actually matters.
Holistic evaluation of large language models for medical tasks with MedHELM - Nature Medicine
MedHELM, an extensible evaluation framework including a new taxonomy for classifying medical tasks and a benchmark of many datasets across these categories, enables the evaluation of large language mo...
nature.com
🧠💥 Decoding how opioids relieve pain—beyond sensation New work reveals how the anterior cingulate cortex (ACC) encodes the affective dimension of chronic pain—and how opioids selectively modulate this circuit.
Mimicking opioid analgesia in cortical pain circuits - Nature
The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...
nature.com
🦴🧬 Precision RNA delivery for osteoarthritis Intra-articular RNA therapeutics hold promise in OA—but efficacy hinges on getting the therapy to the right cartilage, at the right disease stage.
Client Challenge
nature.com
🧠🔊 Mapping consciousness with precision A new review highlights transcranial focused ultrasound (tFUS) as a breakthrough, non-invasive tool for probing the neural basis of conscious perception in humans.
Transcranial focused ultrasound for identifying the neural substrate of conscious perception
Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While pro…
sciencedirect.com
CAR-T saves lives—but we’re still missing the full picture 🧩 In Episode 8 of The Translational Edge, we dive into a novel method 🔬 that could transform how we monitor CAR-T cells in patients—answering long-standing questions about persistence, trafficking, and real-time response 📊
Shuf.ai
Shuf turns any medical content into a new format with AI so that you can increase your audience
shuf.ai
Adipose Manipulation Transplantation as a New Cancer Therapy Platform - Yan Leyfman @yleyfman.bsky.social oncodaily.com/voices/yan-l... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Yan Leyfman: Adipose Manipulation Transplantation as a New Cancer Therapy Platform - OncoDaily
Yan Leyfman: Adipose Manipulation Transplantation as a New Cancer Therapy Platform / cancer, OncoDaily, Oncology, Pancreatic Cancer, Yan Leyfman
oncodaily.com
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