The second story from my PhD is now online! We found that the +1 nucleosome actively functions in the initiation-elongation transition of Pol II transcription. Many thanks to @jabrilgarrido.bsky.social for the great collaboration and everyone involved! authors.elsevier.com/sd/article/S...

The +1 nucleosome functions in RNA Pol II transcription initiation and the transition to elongation

By combining biochemical assays and electron cryo-microscopy, Zhan, Abril-Garrido, et al. elucidated key steps of transcription initiation and the transition to elongation in the presence of the +1 nu...

cell.com

🛠️💉It's time for engineering contractile injection systems! @chipericson.bsky.social & @davidschaumann.bsky.social introduce programmable CIS - PROCIS, combining tail length control, non-native cargo loading, and cell retargeting all in one system! www.biorxiv.org/content/10.6... 🧵 1/5

Excited to share a preprint which is currently under revision! Together with the amazing @ymzhan.bsky.social in @patrick-cramer.maxplanck.de lab, we describe that the +1 nucleosome actively regulates the transition from transcription initiation to elongation www.biorxiv.org/content/10.6... 1/