1/ We are thrilled to share that CHRF has been awarded a Wellcome Discovery Award to study severe RSV pneumonia in children. Read more in our press release: chrfbd.org/blogs/2c839d...

1/ In April 2024, a routine lab isolate of Salmonella Typhi showed phenotypic resistance to ceftriaxone, a key antibiotic for treating typhoid. By September, 47 similar cases had been identified across Bangladesh, and resistance had risen to 5%.

I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’ doi.org/10.1101/2025...

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage

Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could aver...

doi.org

One ceftriaxone-resistant #typhoid case last year set us on a path that is now live on Emerging Infectious Diseases. 47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1. #AMR #PublicHealth wwwnc.cdc.gov/eid/article/...

Outbreak of Ceftriaxone-Resistant <em>Salmonella enterica</em> Serovar Typhi, Bangladesh, 2024

Ceftriaxone-Resistant <em>Salmonella</em> Typhi, Bangladesh

wwwnc.cdc.gov

1/ Outbreaks don't stop during holidays. #Surveillance is year-round work and here is an urgent report on an ongoing outbreak of ceftriaxone-resistant #Salmonella #Typhi in Bangladesh. 📄 Findings: www.medrxiv.org/content/10.1... 🧵

Investigation of an ongoing outbreak of ceftriaxone-resistant Salmonella enterica serovar Typhi in Bangladesh

We report an outbreak of ceftriaxone-resistant Salmonella Typhi in Bangladesh, with 47 cases identified from April-September 2024. Isolates belong to genotype 4.3.1.2 and harbor the blaCTX-M-15 gene o...

medrxiv.org

This is amazing and important work by Glen Carter and colleagues at the University of Melbourne 'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus' www.nature.com/articles/s41...

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin - Nature

Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.

nature.com

When people ask me what we need the most for typhoid treatment, I always say a rapid diagnostic to accurately detect typhoid/paratyphoid. This truly could be a game changer if we can adopt it in clinical practice in LMICs. Great work from colleagues at @chrfbd.bsky.social and collaborators!!

Child Health Research Foundation@chrfbd.bsky.social · 2y ago

At CHRF, we evaluated the accuracy of the Dual-Path Platform for Typhoid (DPPT) assay in diagnosing suspected enteric fever in children. To explore details, read our recent publication: www.thelancet.com/journals/lan... (1/5)

Had the amazing opportunity to present our work at HCA Asia. RSV infections are a major health burden amongst children in Bangladesh and we aim to learn about the pathophysiology of RSV infections using single cell sequencing. Stay tuned for more insights from our work!

Child Health Research Foundation@chrfbd.bsky.social · 2y ago

Dr. Yogesh Hooda presented our latest updates on single cell genomics the HCA Asia 2024 Meeting in Hong Kong. He presented “Single-Cell Analysis of the Nasal Mucosa of Children during Respiratory Infections”. (1/5)

My heart swells with pride every time I realise that Bangladesh is generating its own single cell data @chrfbd.bsky.social !! Excellent presentation by @yogihooda.bsky.social at the #HCAAsia2024 meeting describing the changes in the nasal mucosa during #RSV infections!

Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of... #LMBResearch

Aging together, striving to become better scientists together, getting through this world together. 14 years with @yogihooda.bsky.social since our first date night - crazy!!!

Dr. Senjuti Saha recently took the stage at Cambridge University to share insights on the growing crisis of neonatal infections and antimicrobial resistance (AMR) in Bangladesh. She discussed how CHRF’s invasive bacterial disease surveillance is revealing crucial data on Klebsiella pneumoniae. (1/4)

Excited to share our preprint on characterizing NACHO, a ER-resident membrane protein that plays an essential role in assembling pentameric ion channels, like GABA and nicotinic acetylcholine receptors in our brains. #IonChannels #Neuroscience (1/5) www.biorxiv.org/content/10.1...

Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels

Pentameric ligand-gated ion channels (pLGICs) are cell surface receptors of crucial importance for animal physiology[1][1]–[4][2]. This diverse protein family mediates the ionotropic signals triggered...

biorxiv.org

Recently, I got an opportunity to present 18 years of impactful research from CHRF in Bangladesh at the 2024 Klebsiella Epidemiology and Biology Symposium in Paris—the first-ever event dedicated to this infection. (1/3)