A fun article about our work and the Olympics. There's some interesting relationships between skiing and basal ganglia function. Also see the front of @cmu.edu 's homepage! @cmuscience.bsky.social @cmu-neuroscience.bsky.social @ahmarilab.bsky.social theconversation.com/hesitation-i...

Hesitation is costly in sports but essential to life – neuroscientists identified its brain circuitry

There are specific parts of the brain that trigger hesitation in times of uncertainty.

theconversation.com

Hot off the @nature.com press!! Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties @flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu www.nature.com/articles/s41...

Mimicking opioid analgesia in cortical pain circuits - Nature

The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...

nature.com

So proud of @mattgeramita.bsky.social and this stellar work on striatal dynamics, decisions, and impulsivity. Really pertinent for thinking about probabilistic vs deterministic frameworks too And yes the song by @ahmarilab.bsky.social is absolutely worth listening to!

Matt Geramita@mattgeramita.bsky.social · 8mo ago

Excited to share my postdoc work with @yttrilab.bsky.social and @ahmarilab.bsky.social where we show that the striatal indirect pathway mediates hesitation in mice (www.nature.com/articles/s41...). And I'm honored to have @ahmarilab.bsky.social introduce the findings with a musical abstract!

I hope this new-ish paper will challenge people to think about the interpretations of our models STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!) tinyurl.com/HodgeAndYttri @cmuscience.bsky.social @cmu-neuroscience.bsky.social #neuroskyence

Striatal modulation supports context-specific reinforcement and not action selection

Hodge et al. used closed-loop optogenetic stimulation and naturalistic behaviors to determine that striatal activity does not select the action to perform but rather biases performance through reinfor...

tinyurl.com

In an effort to bring #neuroskyence to @bsky.app I wanted to share our recent paper in Neuron tinyurl.com/LesionsOfM1 @markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions @cmuscience.bsky.social @the-cnbc.bsky.social

Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions

Nicholas and Yttri find that in the absence of motor cortex, the stratum alone is not capable of producing goal-directed behavior. Lesions of motor cortex also produce a freezing of gait-like behavior...

tinyurl.com