What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach? I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:
maybe we just need more positive visions of what the future could look like if we develop mirror life
nothing cooler than watching a friend literally turn science fiction into reality it's been awe-inspiring to watch @andrewcpayne.bsky.social and co build E11 Bio and prove that the FRO model can produce amazing, unique science also expansion + molecular barcoding <3
Andrew Payne@andrewcpayne.bsky.social · 2y ago🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap
Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay www.cell.com/cell-reports...
Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay
Tay et al. demonstrate an antigen-specific assay producing exhausted T cells that reflect those found in human tumors. They identify IKZF1 (IKAROS) as a driver of exhaustion progression and validate t...
cell.com
to shy posters, a reminder that you can literally just post about science you think is cool & if you're looking for the next single-cell or spatial, I suspect single-molecule sequencing is about to blow up 👀 www.cell.com/cell/fulltex... www.biorxiv.org/content/10.1... www.nature.com/articles/s41...
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...
cell.com
just a pic of my dog maple taking "be one with nature" a little too literally
New episode! This time on The Climate Biotech Podcast, Homeworld Collective co-founders Dan Goodwin and Paul Reginato sit down with the legendary George Church—a pioneer in genomics and synthetic biology. Spotify: open.spotify.com/episode/6LfF... Apple Podcasts: podcasts.apple.com/us/podcast/e...
who knew it would be easier to get everyone to switch social media platforms than getting them to use hg38
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it" www.cell.com/action/showP...
cell.com
wake up babe, new george church skincare routine just dropped www.biorxiv.org/content/10.1...
Human skin rejuvenation via mRNA
Aging is characterized by a gradual decline in function, partly due to accumulated molecular damage. Human skin undergoes both chronological aging and environmental degradation, particularly UV-induce...
biorxiv.org
seems like a fun game for all the scientists excited by the move but also mourning having to rebuild their following (it me) I once made a meme to explain all of the drama surrounding the word "epigenetics" - to my horror, it is now used in at least several PhD classes
Sarah Cupcakes@cupcakesarenice.bsky.social · 2y agoI have a game. What were you "known" for on Twitter? I'll go first. I'm the woman who caused Dave Ramsey to mass-block Royals Twitter.
Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...
Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain - Nature Communications
Mapping the nature of multiprotein nanostructures in cellular contexts remains challenging. Here, Kang and Schroeder et al. report multiplexed expansion revealing, a technique which expands proteins a...
nature.com
7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/
