Bryan Roth
@zenbrainest.bsky.social
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
Wow!! Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer www.cell.com/cell/fulltex...
Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinica...
cell.com
Altered Gi signaling in enteroendocrine K cells in vivo causes pronounced changes in glucose homeostasis | Science Advances www.science.org/doi/10.1126/...
Altered Gi signaling in enteroendocrine K cells in vivo causes pronounced changes in glucose homeostasis
Inhibition of Gi-type G proteins expressed by gastrointestinal K cells promotes insulin release and lowers blood glucose levels.
science.org
Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice | Science Advances www.science.org/doi/10.1126/...
Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice
Chemogenetic PV interneuron activation simultaneously rescues seizures and social deficits in polygenic absence epilepsy mice.
science.org
Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior | Science Advances www.science.org/doi/10.1126/...
Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior
Posterior striatal circuits control sensory-guided actions and are disrupted in a rodent model of neurodevelopmental disorders.
science.org
'Psilocybin engages 5-HT2A receptor-dependent dendritic signaling in frontal cortical pyramidal neurons' www.biorxiv.org/content/10.6...
Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors
How psychedelics act on cortical dendrites to produce long-lasting structural plasticity remains poorly understood. Here, we characterize the effects of psilocybin on dendritic calcium dynamics in pyr...
biorxiv.org
We get asked often - what is the duration of psilocybin's effects in the mouse brain? 🧠 There exist data, and now we have also measured it ourselves: Time to peak was 33 min and brain half-life was 56 min. Part of a preprint on drug-evoked dendritic Ca2+ signals: www.biorxiv.org/content/10.6...
“Seven days after the girl’s medical team infused trillions of viruses carrying the recipe for the base editor into her spinal fluid, she died of a severe immune reaction linked to the therapy…” This, in @science.org, is an important and tragic story. (It’s also an incredibly well reported one.) 🧪
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
science.org
Very cool paper! Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity www.nature.com/articles/s41...
Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity - Nature Communications
In this work, small-molecule ligands of neurotensin receptors were identified using structure-based virtual screening, leading to the discovery of potent agonists with in vivo antinociceptive effects ...
nature.com
Cool! Design of a new psychedelic quipazine analog with therapeutic efficacy and potentially fewer side effects #psychedelics www.science.org/doi/10.1126/...
Design of a new psychedelic quipazine analog with therapeutic efficacy and potentially fewer side effects
A psychedelic derivative promotes synaptic and behavioral plasticity without affecting GI motility.
science.org
Integrated 5-HT2A–TrkB and G protein signaling in serotonergic psychedelic responses #psychedelics pubmed.ncbi.nlm.nih.gov/42463904/
Integrated 5-HT2A-TrkB and G protein signaling in serotonergic psychedelic responses - PubMed
Serotonergic psychedelics have attracted considerable interest as promising therapeutic agents. However, the molecular mechanisms linking their acute hallucinogenic-like effects to longer-lasting neur...
pubmed.ncbi.nlm.nih.gov
Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex: Neuron www.cell.com/neuron/fullt...
Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex
Bissen et al. show that prey capture learning profoundly reshapes visual cortical circuitry and function during developmental critical periods, but not in adulthood. These learning-induced structural ...
cell.com
Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells pubs.acs.org/doi/full/10....
Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells
The serotonergic psychedelic N,N-dimethyltryptamine (DMT) produces rapid antidepressant effects in preclinical and early clinical studies. Therapeutic benefits have been linked to sustained neural pla...
pubs.acs.org
An anti-PMEL antibody−drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial Inhibitor=FR900359 www.nature.com/articles/s41...
An anti-PMEL antibody−drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial - Nature Medicine
In a phase 1 trial, treatment with the antibody−drug conjugate DYP688, targeting PMEL and delivering a Gq/11 inhibitor, in patients with GNAQ/GNA11-mutant metastatic uveal melanoma or other GNAQ/GNA11...
nature.com
Opposing GIPR brainstem circuits differentially control feeding behaviour https://www.biorxiv.org/content/10.64898/2026.07.01.735388v1
Basal forebrain projections to the lateral habenula sex-dependently regulate ethanol and sucrose consumption https://www.biorxiv.org/content/10.64898/2026.07.02.736151v1
Interesting paper: Psychedelics produce enduring enhancement of reward responsiveness in male rats #psychedelics www.nature.com/articles/s41...
Psychedelics produce enduring enhancement of reward responsiveness in male rats - Neuropsychopharmacology
Neuropsychopharmacology - Psychedelics produce enduring enhancement of reward responsiveness in male rats
nature.com
Really, really appreciate the effort @biorxivpreprint makes--now with: FULL TEXT FORMATTED/EMBEDDED IMAGE FORMAT (JUST LIKE A *REAL* JOURNAL) Check this out: biorxiv.org/content/10.6...
Hutter Says 'Check It Out' While Using Phone
ALT: Hutter Says 'Check It Out' While Using Phone
static.klipy.com
When there are summer interns in the lab, I often think more about the ambitions of people earlier in the academic science pathway. It often triggers these considerations. From the Archive: In which BikeMonkey discusses "ambition". drugmonkey.wordpress.com/2007/11/13/i...
In which BikeMonkey discusses “ambition”.
I was going to reply to the DM’s query on “ambition” in science careers (motivated by FSP here, followups here and here) in a comment but it got a bit lengthy. So, I present my am…
drugmonkey.wordpress.com
Autonomic C1 neurons promote anxiety via activation of vlPAG: Neuron www.cell.com/neuron/fullt...
Autonomic C1 neurons promote anxiety via activation of vlPAG
Fernández-Peña et al. used viral intersectional tools to selectively target epinephrine-expressing C1 neurons in mouse rostral ventrolateral medulla (RVLM). Adjusting their activity altered the severi...
cell.com
Ligand-Specific Effects of 5-HT2A Receptor Antagonists on Fear Extinction in C57BL/6J Mice: Comparative insights from MDL 11,939 and MDL 100,907 https://www.biorxiv.org/content/10.64898/2026.06.29.735330v1
Chemogenetic inhibition of the noradrenergic locus coeruleus promotes the development of risk-taking decisional strategies and selectively enhances motor impulsivity in females https://www.biorxiv.org/content/10.64898/2026.07.02.736138v1
Meditation Depth Enhances the Functional Signal-to-Noise Ratio of the Brain https://www.biorxiv.org/content/10.64898/2026.06.30.735351v1
Our observations support a nuanced acute psychedelic effect on brain entropy, empirically demonstrating that these metrics do not reflect a singular construct. #psychedelics www.nature.com/articles/s41...
Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy - Nature Communications
Five of 14 fMRI brain entropy metrics tracked acute psilocybin effects in healthy humans across data denoising pipelines in this replication study. This research highlights candidate clinical biomarke...
nature.com
New chemogenetic tool! www.nature.com/articles/s41...
Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent
nature.com
Nondual mindfulness meditation alters self representation and brain connectome in expert meditators https://www.biorxiv.org/content/10.64898/2026.07.01.735757v1
