Excited to share our recent paper (doi.org/10.1016/j.ce...)! In this multi-year effort, we developed RT&T-AMP-MERFISH, enabling whole-transcriptome-scale, isoform-resolved single-cell spatial transcriptomics and imaging ~33,000 RNAs in the brain.

What is the global structure of cell-state space—and how do perturbations drive transitions within it? Excited to share our new preprint (www.biorxiv.org/content/10.6...), a work in collaboration with @weissmanlab.bsky.social.

Check out this preprint on Perturb-multi (doi.org/10.1101/2024...), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing. bsky.app/profile/weal...

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function

Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...

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