Amir Toor
@aat2357.bsky.social
Stem cell transplant physician; apply mathematics to immunology; Professor UTSW
www.medrxiv.org/content/10.6...
Spectral Analysis of the T Cell Repertoire Recovery Following Allogeneic Stem Cell Transplantation
The human T cell repertoire is generated through recombination of a multitude of T cell receptor gene segments, yielding a complex array of T cell clones. T cell receptor beta (TRB) V gene segment def...
medrxiv.org
www.science.org/doi/10.1126/...
Uneven TCR chain pairing constraints govern epitope recognition
Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope reco...
science.org
Teclistamab in Multiple Myeloma with One to Three Previous Lines of Therapy | New England Journal of Medicine www.nejm.org/doi/full/10....
Teclistamab in Multiple Myeloma with One to Three Previous Lines of Therapy | NEJM
The efficacy of teclistamab, a bispecific antibody targeting B-cell maturation antigen and CD3, as early-line monotherapy in relapsed or refractory multiple myeloma is unclear. We randomly assigned...
nejm.org
Turning up the temperature on the world’s hottest forests | Science | AAAS www.science.org/content/arti...
Turning up the temperature on the world’s hottest forests
Innovative experiments are revealing how plants in the tropics can cope with heat
science.org
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
nature.com
www.nature.com/articles/s41...
Fasting boosts breast cancer therapy efficacy via glucocorticoid activation - Nature
Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting...
nature.com
www.medrxiv.org/content/10.1...
T cell tolerant fraction as a predictor of graft-vs-host disease following allogeneic hematopoietic cell transplantation
Background Donor T cell reconstitution following allogeneic hematopoietic cell transplantation (HCT) is crucial for protective immunity against infections and cancer relapse. However, its use remains ...
medrxiv.org
Tumor Lysis Syndrome | New England Journal of Medicine www.nejm.org/doi/full/10....
Tumor Lysis Syndrome | NEJM
Tumor lysis syndrome has evolved and become less predictable with the introduction of new cancer therapies. This review explores risk factors and causes of the syndrome, as well as strategies for t...
nejm.org
The IL-33 and IL-4Rα blocking antibodies itepekimab and dupilumab modulate both distinct and common inflammatory mediators in asthma | Science Translational Medicine www.science.org/doi/10.1126/...
science.org
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine | Science Immunology www.science.org/doi/10.1126/...
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall.
science.org
T-cell lymphopenia characterizes immunodeficiency in a broad spectrum of TBDs. buff.ly/6B7IlyR #hemesky
