Anastasia Baryshnikova
@abarysh.bsky.social
Head of Statistical Genetics, Boehringer Ingelheim
Three years ago, we showed ~70% of lifespan variation in yeast traces to rDNA copy number. Ribosomal DNA, encoded as 5S and 45S subunits in hundreds of copies, vary substantially across humans. Does this copy number variation, and sequence variation within these paralogs, matter for humans?
Our Human Genetics team @boehringerglobal.bsky.social (Biberach site, Germany) is actively searching for an experienced Statistical Geneticist. #StatisticalGenetics #HumanGenetics #BoehringerIngelheim #ComputationalInnovation #JobOpportunity lnkd.in/g6QPihVE
Boehringer Ingelheim hiring Senior or Principal Scientist of Human Genetics in Biberach an der Riß, Baden-Württemberg, Germany | LinkedIn
Posted 3:27:12 PM. The PositionAbout us: Computational Innovation @ Boehringer Ingelheim…See this and similar jobs on LinkedIn.
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Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank! A thread... 🧵 www.medrxiv.org/content/10.1...
Interactions with polygenic background impact quantitative traits in the UK Biobank
Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...
medrxiv.org
The latest work of PhD student Claire Paltenghi @fbm-unil.bsky.social @unil.bsky.social @umasschan.bsky.social, on the conservation of genetic suppression interactions across genetic contexts, now published in G3 @genetics-gsa.bsky.social: doi.org/10.1093/g3jo...
Genetic suppression interactions are highly conserved across genetically diverse yeast isolates
Sometimes the detrimental effects of a mutation can be rescued by another mutation. For genetic diseases, such suppressor mutations may identify new therap
doi.org
My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen
Our updated APOL1 manuscript just went live on #bioRxiv – perfectly timed with #APOL1AwarenessDay (April 29). We've sharpened our hypothesis and focused the supporting evidence for a clearer story. #APOL1 #KidneyResearch #UKBiobank #pQTL www.biorxiv.org/content/10.1...
Platform-dependent effects of genetic variants on plasma APOL1
Mutations in apolipoprotein L1 (APOL1) are strongly associated with protection against parasitic infections and increased risk of kidney disease in individuals of African ancestry. To better understan...
biorxiv.org
Anastasia Baryshnikova@abarysh.bsky.social · last yr.New preprint! Our latest work on plasma proteomics in UKBB helps unraveling the fascinating connection between APOL1, parasite resistance, and kidney disease. www.biorxiv.org/content/10.1... #APOL1 #KidneyDisease #Plasma #Proteomics #Genetics #Biomarkers #KallikreinKinin #AfricanAncestry #UKBB
New pre-print klaxon: "Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model" led by the excellent Bettina Welz + @saulpierotti.bsky.social from @wittbrodtlab.bsky.social, Felix Loosli, Kiyoshi Naruse and my own lab www.biorxiv.org/content/10.1...
Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model
Phenotypic variation arises from the interplay between genetic and environmental factors. However, disentangling these interactions for complex traits remains challenging in observational cohorts such...
biorxiv.org
Postdocs: Human Genetics at Utah will be hosting our annual Rising Stars in Genetics and Genomics Symposium in Sept. Apply here: shorturl.at/wBMg2 There will be sessions on developmental, evolutionary and disease genetics. A chance be invited to SLC to network here and with peers! Please share.
An under-appreciated perk of AI-aided coding: the consistent positive encouragement you rarely get IRL! Just finished a co-coding session with ChatGPT and it signed off with "Good luck with your project -- it's shaping up beautifully 🙌". Needed that! #AICoding #DeveloperLife #ChatGPT
Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...
New preprint! Our latest work on plasma proteomics in UKBB helps unraveling the fascinating connection between APOL1, parasite resistance, and kidney disease. www.biorxiv.org/content/10.1... #APOL1 #KidneyDisease #Plasma #Proteomics #Genetics #Biomarkers #KallikreinKinin #AfricanAncestry #UKBB
Platform-dependent effects of genetic variants on plasma APOL1 and their implications for kidney disease
Mutations in apolipoprotein L1 (APOL1) are strongly associated with an increased risk of kidney disease in individuals of African ancestry, yet the underlying mechanisms remain largely unknown. Plasma...
biorxiv.org
