We're hiring a Research Associate! We are looking for someone who's organized and comfortable managing day-to-day lab operations while also supporting ongoing experiments. Referrals very welcome, or apply directly here: careers-umms.icims.com/jobs/52001/j...

About UMass Chan Medical School

Our mission is to advance the health and wellness of our diverse communities throughout Massachusetts and across the world by leading and innovating in education, research, health care delivery and pu...

careers-umms.icims.com

Allostery is a widespread cause of loss-of-function variant pathogenicity by @xt117.bsky.social @sangerinstitute.bsky.social www.nature.com/articles/s41...

Allostery is a widespread cause of loss-of-function variant pathogenicity - Nature Communications

Mutations at sites distant from a protein’s active site can disrupt function through allosteric mechanisms. Here, authors present evidence that allostery is a widespread and underappreciated cause of ...

nature.com

Excited to share our new opinion piece exploring the potential of genetic suppressors—genetic variants that can rescue disease-causing mutations—as novel therapeutic targets for rare inherited diseases. Take a look here: www.cell.com/trends/genet... #RareDiseases #Therapeutics #Genetics

Now published! www.cell.com/cell-systems...

The modifiers that cause changes in gene essentiality

A systematic study of gene essentiality across 18 genetically diverse natural yeast strains identifies 39 genes that are essential in the laboratory reference strain but not in at least one other gene...

cell.com

Jolanda van Leeuwen@jsvanleeuwen.bsky.social · 2y ago

Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1... So what did we find?

Abstract submission is open! Looking forward to seeing everyone in Pacific Grove, CA 🧬

Saccharomyces Genome Database@yeastgenome.bsky.social · 7mo ago

Join SGD at #Yeast26 for cutting-edge #yeast research, networking opportunities, engaging talks, poster sessions, and workshops, for everyone from early career scientists to experienced researchers! Abstract submission by Mar5, early registration ends Apr16. See you there! @genetics-gsa.bsky.social

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26 genetics-gsa.org/yeast-2026/

Join a collaborative home of Nobel Prize-winning biomedical research. Advance discoveries of the treatment and prevention of diseases. The Morningside Graduate School of Biomedical Sciences is accepting applications for the Biomedical Sciences PhD program: direc.to/nEHU #PhD #PhDSky

I’m excited to highlight our latest paper, just published in Cell 🎉 We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression. 1/n 🧪 www.cell.com/cell/fulltex...

RNA Pol II inhibition activates cell death independently from the loss of transcription

When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...

cell.com

The May issue of #G3journal features work by Paltenghi and @jsvanleeuwen.bsky.social which identifies highly conserved genetic suppression mechanisms across genetically diverse yeast isolates in an effort to reduce disease severity in genetic disorders. Read more: buff.ly/AhEqx0f

The latest work of PhD student Claire Paltenghi @fbm-unil.bsky.social @unil.bsky.social @umasschan.bsky.social, on the conservation of genetic suppression interactions across genetic contexts, now published in G3 @genetics-gsa.bsky.social: doi.org/10.1093/g3jo...

Genetic suppression interactions are highly conserved across genetically diverse yeast isolates

Sometimes the detrimental effects of a mutation can be rescued by another mutation. For genetic diseases, such suppressor mutations may identify new therap

doi.org

<grumble> funding agencies, scoring schemes on “clarity of hypothesis” is quite a straightjacket. There is plenty of v good discovery/ hypothesis generating science which doesn’t have a “narrow” hypothesis

For those of you interested in cancer synthetic lethality, this should be a v interesting Gordon Conference organised by @mgarnett.bsky.social @vazquezf.bsky.social & Benjamin Schwartz- highly recommended ! www.grc.org/synthetic-le...

Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1... So what did we find?

The modifiers that cause changes in gene essentiality

biorxiv.org

We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church. www.science.org/doi/10.1126/...

Randomizing the human genome by engineering recombination between repeat elements

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

science.org

Yeast Genetics & Genomics at CSHL July 22 - August 12, 2025 Application Deadline: March 31, 2025 Arrival: July 22nd by 6pm EST Departure: August 12th around 12pm EST For more info and to apply please visit the Yeast Genetics & Genomics course website: meetings.cshl.edu/courses.aspx...

📢 #Yeast2025 News! Registration and abstract submission are NOW OPEN! Join us at the 32nd ICYGMB 📅 Save the Date: 21-24 July 2025 📍 Location: Paris @sorbonne-universite.fr 🔗 Submit: premc.org/yeast2025/su... 🕒 Register now to take advantage of the Early Bird fee premc.org/yeast2025/re...

Come join us at CSHL in March for the Network Biology meeting! Less than two weeks left to submit your abstract

CSHL Meetings@cshlmeetings.bsky.social · 2y ago

FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here: bit.ly/40cIfSl @fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social

Hey #networkbiology bubble and affinionados. Don't miss the CSHL Meeting: Network Biology in spring 2025. Great panel of speakers lined up by the organizers @fritzroth.bsky.social @pedrobeltrao.bsky.social, Roded Sharan, and @jsvanleeuwen.bsky.social. meetings.cshl.edu/meetings.asp...

Network Biology

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu

Calling all systems and computational biologists in search of a faculty position: We have Assistant and Associate Professor positions! 🚀 Pittsburgh is beautiful, and we are doing amazing science here. cfopitt.taleo.net/careersectio... cfopitt.taleo.net/careersectio... Please apply by Dec 2!