Abraham Acevedo

@acevedolab.bsky.social

Molecular biologist, almost neuroscientist, neurodegeneration, ALS, mouse models

Congratulations to Dr Claire Leckey my PhD student. Using stable isotope labelled leucine we measured synthesis and turnover of neurofilament light in patients. The protein turns over very slowly showing brain trials need long timelines to reveal benefit. academic.oup.com/braincomms/a...

Stable isotope labelling kinetics of neurofilament light

Leckey et al. report novel measures of neurofilament light chain kinetics in the human central nervous system using stable isotope labelling. Translation o

academic.oup.com

2024 Swedish study on 2.5M people's data: "Acetaminophen use during pregnancy was not associated with children’s risk of autism, ADHD, or intellectual disability... This suggests that associations observed in other models may have been attributable to confounding." jamanetwork.com/journals/jam...

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

jamanetwork.com

An evergreen thread: Race/Ethnicity is *not the same* as genetics, and you can't use Race/Ethnicity as a sort of stand-in for genetics. These two concepts are connected via aspects like skin colour, but the connection is alot less profound and categorical than most people think.

Geneticist Liane Russell was born #OTD in 1923. She pioneered the study of mutagenesis and teratogenesis due to radiation, and identified the role of the Y chromosome in sex determination. Her work led to diagnostic x-ray safety standards for women of childbearing age. 🧪 👩‍🔬 ⚛️

A young Liane Russell working with a mouse. She is in a lab, wearing a white shirt. Someone outside the frame of the picture is also touching the mouse. Image: @ORNL