Our preprint, where we infer the fitness effects of new mutations in regulatory regions of the D. melanogaster genome. We find an abundance of weakly deleterious effects - www.biorxiv.org/content/10.6... Led by @adaigle.bsky.social .

Delighted and grateful for this recognition from @sse-evolution.bsky.social. The Dobzhansky Prize is a special honor, and I'm thrilled to have been in the conversation this year. Big congrats to Wendy Valencia-Montoya!

Society for the Study of Evolution@sse-evolution.bsky.social · 4mo ago

We are also pleased to announce the Dobzhansky Prize Honorable Mention, Dr. Sean Anderson! Learn more about his work: www.evolutionsociety.org/news/display... @seananderson.bsky.social

Congratulations to the winners of the 2025 Genomic History Inference Strategies Tournament challenges! Among the 9 challenges, we had five winners: @alwaysrong.bsky.social, @adaigle.bsky.social, @andrewhvaughn.bsky.social, @thymelicus.bsky.social, @rgollnisch.bsky.social

Community competitions help benchmark approaches in computational biology. Struck et al. now present GHIST 2024 - The First Genomic History Inference Strategies Tournament, for the inference of evolutionary history from genome data. 🔗 doi.org/10.1093/molbev/msaf257 #evobio #molbio #compbio #popgen

New research by @tylervkent.bsky.social @samurscicop.bsky.social & D. Matute analysed 131 genomes of the globally invasive Aedes aegypti, and found high genomic resilience despite historical eradication attempts for this globally invasive vector. 🔗 doi.org/10.1093/gbe/... #genome #mosquitoes

Demographic History, Genetic Load, and the Efficacy of Selection in the Globally Invasive Mosquito Aedes aegypti

Abstract. Aedes aegypti is the main vector species of yellow fever, dengue, Zika, and chikungunya. The species is originally from Africa but has experience

doi.org

Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...

Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin

The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the eff...

doi.org

Excited to see the final version of this paper with @samurscicop.bsky.social and Daniel Matute out in @genomebiolevol.bsky.social! We took a dive into the complicated demographic history of Aedes aegypti mosquitoes and its impact on the distribution of genetic diversity doi.org/10.1093/gbe/...

Demographic history, genetic load, and the efficacy of selection in the globally invasive mosquito Aedes aegypti

Abstract. Aedes aegypti is the main vector species of yellow fever, dengue, Zika and chikungunya. The species is originally from Africa but has experienced

doi.org

Amid the chaos, it was great to share results from the first Genomic History Inference Strategies Tournament at ProbGen25. Watch the talk to learn about the future of GHIST and @andrewhvaughn.bsky.social's nefarious metagaming of demographic inference. 😀 www.youtube.com/watch?v=3_dv...

Talk describing the results of GHIST1 at ProbGen 25.

YouTube video by Ryan Gutenkunst

youtube.com

Every day I wake up to new horrors and my Id demands blood but I have written this paper on pseudo-overdominance in polyploids instead www.biorxiv.org/content/10.1...

Recombination and the role of pseudo-overdominance in polyploid evolution

Natural selection is an imperfect force that can under some conditions fail to prevent the buildup of deleterious mutations. Small population sizes and the lack of recombination are two such scenarios...

biorxiv.org

Excited to share my first PhD project with my mentor, @johriparul.bsky.social! We examine how Hill–Robertson interference (HRI) in highly selfing species biases estimates of the distribution of fitness effects of new mutations (DFE). doi.org/10.1093/evol... @journal-evo.bsky.social #popgen #evobio

Thrilled to have been part of the inaugural GHIST competition in population genetics inference! Big thanks to the organizers for a fun and challenging event. Congrats to Andrew Vaughn and Ekaterina Noskova for their impressive performance, I'm looking forward to reading about everyone's methods.

Ryan Gutenkunst@ryangutenkunst.bsky.social · 2y ago

Congrats to Andrew Vaughn @andrewhvaughn.bsky.social, for winning 3 out of 4 challenges in the inaugural GHIST competition in population genetics inference. He not only submitted accurate inferences, he also gamed the system by further optimizing his score beyond the maximum likelihood inferences. 😜