Tyler Kent
@tylervkent.bsky.social
Postdoc @ University of Chicago Ecology & Evolution Evolutionary genomics mostly The opinions expressed are my own, and they do not necessarily represent the views or opinions of my employer
🚨 The Grieshop Lab is hiring at all levels!!! 🚨 Oct 2027 start: 👉 4-year BBSRC-funded PhD position (closes 30 Nov) 👉 3.5-year NERC-funded PhD position (closes 16 Dec) Feb 2027 start: 👉 3-year NERC-funded post-doc 👉 3-year NERC-funded lab tech 👉 (part-time) 3-year NERC-funded tech
*** please share widely *** Georgia Tech is hiring an ecologist tinyurl.com/GT-eco-coasts - general search - submit by Dec 1 - come join us, we have a growing group of excellent + collegial eco eco folks (e.g., @armanafzadeh.bsky.social, Sean Anderson, @jameststroud.bsky.social, Lauren Speare)
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New preprint from the team #AdaptiveIntrogression #Haplotagging #PopGen #MarEvol "Adaptive introgression in subdivided populations leaves distinct genomic footprints under global and local selection: a case study in Ciona intestinalis" www.biorxiv.org/content/10.6...
Adaptive introgression in subdivided populations leaves distinct genomic footprints under global and local selection: a case study in Ciona intestinalis
Adaptive introgression, the transfer of beneficial alleles between species through hybridization, is increasingly recognized as an important source of adaptation to novel environments. However, the th...
biorxiv.org
actual link: www.biorxiv.org/content/10.6...
Divergence in wilt tolerance across the range of Mimulus guttatus in the absence of stomatal regulation
Whether phenotypes and environments predict performance under stress is central to ecology and evolution and can reveal species' vulnerability to global change. We sampled Mimulus guttatus range-wide ...
biorxiv.org
Just over two weeks left to apply! I may be biased, but it’s hard to imagine a better place to do plant evolutionary biology.
Jeffrey Ross-Ibarra@jrossibarra.bsky.social · 2mo agoI am excited to announce a job for an Asst Prof in Plant Evolution in the dept. of Evolution and Ecology at @ucdavis.bsky.social. We're looking broadly, from macro (speciation, comparative genomics, evo-devo) to micro (pop biology, adaptive evolution, evo-eco). recruit.ucdavis.edu/JPF07777
Very cool new preprint I was very excited to be a VERY small part of, from @viralverity.bsky.social and @nathangrubaugh.bsky.social: "Phylodynamic analysis reveals asymmetric and accelerating global spread of dengue virus" www.biorxiv.org/content/10.6...
I'm hiring a postdoc to help build tools for inferring complex speciation histories with genomic data. strong computational skills are a must, but this is a training opportunity. 60K$+ salary, 2 years, details flexible. please reach out! (and repost) ad here: jobs.montana.edu/postings/53150
Postdoctoral Researcher
The Department of Ecology at Montana State University is seeking a Postdoctoral Research Scholar as part of NSF-funded research on speciation under alternating cycles of gene flow and isolation (fundi...
jobs.montana.edu
Ethan Linck@elinck.bsky.social · 3mo agograteful to have received the lab's first NSF grant to study cyclical processes of speciation with new theory and tools (applied to Melanesian birds). ad to come, but I'll be looking for a postdoc with computational biology chops—please reach out! (and repost) www.nsf.gov/awardsearch/...
I'm hiring a postdoc in population and evolutionary genetics at Indiana University Bloomington! We're a computational lab working on spatial demographic inference using genomic data and machine learning. You can apply here: indiana.peopleadmin.com/postings/34508
Indiana University Academic Positions
indiana.peopleadmin.com
JOB ALERT: UNC Bio is hiring 2 tenure track assistant profs doing molecular, cell, and dev bio. The search is intentionally broad, so please share widely and spread the word! Find more information and apply here: unc.peopleadmin.com/postings/325... Application review begins Nov 1.
New preprint with grad student @linhngk.bsky.social. Big mystery in plants is why do their telomere length vary? We answered by analyzing 10Tb or 1.4 billion reads from 257 species of algae to land plants. We propose ecological adaptation shapes telomere length in plants. shorturl.at/0ox4x
Biogeographic cline is associated with the global plant telomere length variation
Telomeres have the crucial role of protecting chromosome ends and its length varies significantly between organisms. What evolutionary factor shapes this natural variation has been a long standing que...
biorxiv.org
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
I’m keen to share this preprint. There is growing evidence that associative overdominance leads to the maintenance heterozygosity and we wondered how this would affect variance for traits under stabilizing selection: www.biorxiv.org/content/10.6...
Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance
Mutation-selection balance is the most plausible general mechanism for the maintenance of additive genetic variance (VA) for quantitative traits in natural populations. It is well established that the...
biorxiv.org
The (literal) closing of a chapter, former Schrider Lab student Amjad Dabi's paper where he simulates evolutionary rescue scenarios to model the dynamics of treatment resistance in sequential cancer therapy is now published in PLoS Comp Bio: journals.plos.org/ploscompbiol... (1/5)
Evolutionary rescue model informs strategies for driving cancer cell populations to extinction
Author summary Cancer cells often evolve resistance to treatments during therapy by acquiring specific mutations, leading to eventual relapse and treatment failure. While using multiple treatments in ...
journals.plos.org
Dan Schrider@samurscicop.bsky.social · 2y agoIn the latest from the lab (www.biorxiv.org/content/10.1...), PhD student Amjad Dabi used simulation to investigate the emergence of resistance to therapy in cancer under an evolutionary rescue model. Why does treatment for some cancers fail after a period of initial effectiveness? (1/n)
New preprint! 🎉 How do populations adapt to a changing environment? We show how standing genetic variation enables polygenic adaptation, while the speed and magnitude of environmental change can determine whether populations adapt—or go extinct. www.biorxiv.org/content/10.6...
Standing genetic variation drives polygenic adaptation to different environmental shifts
Most organisms are well adapted to the environment they have been exposed to for many generations. However, changing environments pose existential threats to populations, unless they are able to adapt...
biorxiv.org
Princeton EEB is running a very broad faculty search at the Assistant Professor level. Please consider applying to join us! This is a wonderful, collaborative, cohesive department with diverse interests and amazing colleagues. apply.interfolio.com/193474
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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How & why does the distribution of fitness effects #DFE vary among species? Meixi Lin, @klohmueller.bsky.social &co analyze genetic variation from 11 animal species, finding that fitness effects are influenced by phylogeny, population size & organismal complexity @plosbiology.org 🧪 buff.ly/t5q7Mqo
If anyone looking for a postdoc with fantastic genomics/bioinformatics skills + strong intellect + great energy, please let me know! Preferably West Coast or remote/hybrid options & the candidate is open to a short (1 year) or longer term appointment
"...solving problems is only a tool and proxy for achieving the primary goal of conceptual understanding and insight. Forgetting this in the world of AI may turn the tool against the primary goal."
Terence Tao@teorth.bsky.social · last mo.A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...
Can selfish genetic elements get away with their selfishness? This depends on ecology of their host organisms. Under certain conditions, selfish genetic elements may spread virtually unopposed by selection: doi.org/10.1093/jeb/... @martijnschenkel.bsky.social @arvidagren.bsky.social & M. Patten
The ecological theatre of selfish elements
Abstract. Some selfish genetic elements enhance their transmission to the next generation by interfering with and eliminating competing variants within the
doi.org
Job opportunity at Columbia U., in "any combination of field, experimental, computational, or theoretical approaches to study fundamental questions in evolutionary biology".
Andres Bendesky@bendeskylab.com · last mo.We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding
Our lab's first journal cover! Art by @taylorblack.bsky.social and project led by @brynnjohnson13.bsky.social
Taylor Black@taylorblack.bsky.social · last mo.SO PROUD! @brynnjohnson13.bsky.social’s paper on temp dependent competition in secondary contact zones in darters is ofFISHally out in @journal-evo.bsky.social academic.oup.com/evolut/artic... As an extra hurrah related to this work, I had the opportunity to paint a corresponding journal cover!
How long does DNA damage last? @aaronquinlan.bsky.social and I found evidence that lesions are transmitted from parent (P0) to offspring (F1) in C. elegans. If they segregate unrepaired for multiple cell divisions, lesions generate multi-allelism in the F1 germline. www.biorxiv.org/content/10.6...
Inherited DNA damage generates multi-allelic mutations in C. elegans
Exogenous and endogenous mutagens generate a wide variety of DNA lesions, including bulky adducts, chemical modifications, and single- or double-stranded breaks. A phenomenon called “lesion segregation,” in which lesions evade repair and persist for multiple cell divisions, has recently been documented in tumors and healthy somatic tissues from mice and humans, respectively. Persistent lesions can generate multi-allelic variants (MAVs) by serving as templates for multiple rounds of error-prone replication. By reanalyzing data from a large C. elegans mutagenesis experiment, we observed robust evidence for MAVs at a small fraction (∼0.2%) of mutated sites in the offspring of strains treated with alkylating agents. Because these sequencing data were derived from the progeny of a single F1 animal — itself the offspring of a mutagenized P0 — all mutations should be biallelic. The presence of multi-allelic variation implies that some DNA lesions are transmitted to the F1 zygote, evade repair, and are repeatedly bypassed by error-prone polymerases during embryogenesis. We suspect that many more lesions are inherited than is suggested by MAV prevalence, and that a large fraction of biallelic mutations are also caused by inherited lesions. Our results demonstrate that DNA lesions serve as durable, transgenerational templates for mutagenesis in C. elegans . We speculate that lesion segregation in the early embryo may be a source of mosaicism and genetic diversity in humans, as well. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, https://ror.org/01cwqze88, R01HG012252
biorxiv.org
Recombination helps evolution—but it can also cause mutations. New theory shows that even small increases in mutation near crossovers can oppose the evolution of higher recombination rates. By @sarperotto.bsky.social and Bret Payseur academic.oup.com/evlett/advan...
Elevated mutation near crossovers inhibits the evolution of recombination
Abstract. Recombination diversifies offspring genomes and helps ensure chromosome segregation during meiosis. Mutation rates are elevated near crossovers d
academic.oup.com
I am currently searching for a postdoc to work on the evolution of adaptations, cold acclimation, and freezing tolerance in switchgrass. The position entails lab, growth facility, bioinformatics, and fieldwork. careers.msu.edu/jobs/postdoc...
Postdoctoral Scholar-Fixed Term - East Lansing, Michigan, United States
Position Summary The Lowry Lab at Michigan State University is searching for a postdoctoral research associate to conduct field and laboratory experiments to understand the causes of genetic variation...
careers.msu.edu
Transposable Elements and the Impact of Genomic Autoimmunity www.annualreviews.org/content/jour...
Transposable Elements and the Impact of Genomic Autoimmunity
Transposable elements (TEs), originally characterized in maize, are ubiquitous features of eukaryotes and replicate within genomes independent of the host replication cycle. This replicative advantage...
annualreviews.org
Great work by Cian Williams in his fourth year undergrad - predicting the range of an invasive pest in north america informed by genomics of local adaptation in native range - also @henrylnorth.bsky.social www.biorxiv.org/content/10.6...
Genetically informed distribution models refine predictions for the overwintering range of Helicoverpa armigera in North America
The ecological and economic threat posed by invasive pests demands proactive mitigation. Species distribution models (SDMs) are widely used in efforts to predict where invasive species might spread af...
biorxiv.org
What are the genetic mechanisms for the #evolution of novel traits? This study by @brhopkins92.bsky.social &co links #Drosophila sex comb teeth to expression changes within ancestral cells, leading to diverged metabolic/developmental rates, and a novel structure. 🧪 #AcademicSky plos.io/4gQOnZK
