Mine is generally addressed to Reviewer 2, who is petty, ignorant, unfair and self-obsessed.

Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples. 👉 www.researchsquare.com/article/rs-8... @nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social

Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples. 👉 www.researchsquare.com/article/rs-8... @nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social

Heroic effort by Luke Snell, Suzy Pickering and Rui Galao and many colleagues at KCL, clinical collaborators at GSTT and of course the individuals concerned, several of whom sadly passed away.

This is finally out. Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year. This is why persistent infections matter www.cell.com/cell-reports...

Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections

Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...

cell.com

📣 Foley et al assess #syphilis PCR & serology in >8K Australian patients #Serology: still essential for first infections & reinfections #PCR: limited add'l benefit in first infections; w/ serology can improve detection of reinfections #IDSky #clinmicro #diagnosticstewardship ow.ly/hh0M50Y5j50

The utility of combined syphilis PCR and serology during an outbreak in Western Australia: A multicentre retrospective diagnostic evaluation

Syphilis has re-emerged as a global public health concern. Although serology is well established, the role of PCR remains unclear. We evaluated the di…

ow.ly

Today marks the end of #WorldAMRAwarenessWeek! Over the last week on LinkedIn, we have been sharing how respiratory metagenomics supports smarter antimicrobial use and personalised care. 👉 Follow our LinkedIn page to find out more: www.linkedin.com/company/1095... #AMR #WAAW25 #Metagenomics

As #WorldAMRAwarenessWeek wraps up, we share how respiratory metagenomics is transforming care. Faster and accurate detection of pathogens help clinicians target treatment sooner and reduce unnecessary antibiotics, whilst improving personalised care and antimicrobial stewardship across the NHS.

💬 “Learn at scale, deliver at pace.” At today’s Genomics Summit, Prof. Ian Abbs highlighted the NHS Respiratory Metagenomics Network as a great example of partnerships driving innovation & improving clinical practice. 📩 Let’s keep the conversation going! #NHSGenomics2025 #Metagenomics #Genomics

What a year! From expanding to new sites, to celebrating publications and hosting our second annual network event, 2025 has been full of milestones for the network. 🎥 Press play to have a look back at some of what we have achieved this year! #Metagenomics #LifeSciences

We are proud to be working collaboratively with multiple sites including hospitals and laboratories, across the UK, to help scale and advance respiratory metagenomic testing in the NHS. 👇 Check out our map below to see sites that are currently involved in the network. #Metagenomics

This is what systematic racism looks like.

LongTime🤓FirstTime👨‍💻@longtimehistory.bsky.social · 8mo ago

ICE detain U.S. citizen for looking Somali—use illegal chokehold to tackle him to ground. Man repeatedly begs agents to look at his digital passport ID—they refuse. Drove him 7 miles away before releasing him alone into Minnesota snow storm—told him to "walk home" in freezing weather advisory.

H3N2 subclade K dominating early flu season in UK. Emerged at end of the southern hemisphere flu season, varies from the J.2 subclade chosen for this year’s vaccination. Current vaccine still thought to offer protection so… Get your flu Vax! #IDSky #vaccines www.gavi.org/vaccineswork...

Everything you need to know about ‘subclade K’ flu - and vaccine protection against it

As a new branch of H3N2 influenza gains ground, we explore what it means for this season’s flu vaccine.

gavi.org

Our new preprint covering the improvements we made to our respiratory metagenomic assay is out now: www.medrxiv.org/content/10.1... ✅ Now implemented in 6 NHS hospitals ✅ Increased sensitivity ✅ Increased pathogen genome coverage (1/3)

Optimisation of whole cell human depletion provides increased sensitivity and microbial genome coverage from respiratory metagenomic assays

Metagenomics is being adopted worldwide as a laboratory developed test. We have previously reported a unified metagenomic method for the direct detection of microorganisms from respiratory samples, de...

medrxiv.org

Optimisation of whole cell human depletion provides increased sensitivity and microbial genome coverage from respiratory metagenomic assays https://www.medrxiv.org/content/10.1101/2025.10.10.25337716v1

Implementing rapid pan-microbial metagenomics in paediatric intensive care https://www.medrxiv.org/content/10.1101/2025.10.07.25337257v1

What if ICU doctors could diagnose infections in hours, not days? A new test, developed from a PhD project at King's, now makes this possible.🔬 🔗 www.kcl.ac.uk/metagenomics...

Metagenomics testing: From PhD project to the ICU

A new diagnostic test that can detect a broad range of microorganisms in a single sample and give same-day results has been shown to improve the diagnosis and treatment of patients with…

kcl.ac.uk

New research article Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study www.thelancet.com/journals/lan... #IDSky #ClinMicro #OpenAccess #OA

Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study - The Lancet Microbe www.thelancet.com/journals/lan...

Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study

Respiratory metagenomics for ICU patients showed good performance and turnaround time, and diverse clinical and public health benefits. This ability to inform both personalised patient therapy and inf...

thelancet.com

Paracetamol remains an important option to treat pain or fever in pregnant women. Following rigorous assessment of the available scientific data, we find no evidence that taking paracetamol during pregnancy causes autism in children. Read more 👉 www.ema.europa.eu/en/news/use-...

Use of paracetamol during pregnancy unchanged in the EU | European Medicines Agency (EMA)

Paracetamol medicines can be used in pregnancy, in accordance with official recommendations

ema.europa.eu

El “Acuerdo de la Organización Mundial de la Salud sobre Pandemias” (20 de Mayo de 2025) establece un marco integral de acción ante pandemias, que incluye la prevención de zoonosis, la preparación de los sistemas de salud y la equidad en la respuesta. jamanetwork.com/journals/jam...

The WHO Pandemic Agreement

This Viewpoint describes the World Health Assembly’s newly adopted Pandemic Agreement, which lays a framework for action including preventing zoonotic spillovers, health system preparedness, and equit...

jamanetwork.com

Real-Time Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control: Clinical and Economic Impact ✅ Just Accepted ⭐ Editor's Choice ✍️ @sundermannaj.bsky.social #IDSky

Real-Time Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control: Clinical and Economic Impact

Current methods are insufficient alone for outbreak detection in hospitals. Real-time genomic surveillance offers the potential to detect otherwise unidentified outbreaks.

doi.org

Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections https://www.biorxiv.org/content/10.1101/2025.04.17.648944v1

Next speaker was Luke Blagdon Snell with Same-day pan-microbial metagenomics for personalized therapy and pathogen surveillance on the intensive care unit: a single-centre prospective study (escmid.reg.key4events.com/AbstractList...).

Robbie Hammond presented next with Implementing same-day respiratory metagenomic diagnostics in paediatric intensive care (escmid.reg.key4events.com/AbstractList...). Their method had a turnaround time of 6 hours.

New preprint! We developed a fast method that allows the use of hybridization capture workflows with @nanoporetech.com without additional ligation-based steps! We validated our method using targeted viral metagenomics @twistbioscience.com and Viral WGS @Agilent www.medrxiv.org/content/10.1...

Nanopore-based hybridization capture approaches for targeted viral metagenomics and whole-genome sequencing

Hybridization capture approaches can significantly increase the sensitivity of metagenomics. However, their implementation with Oxford Nanopore Technologies (ONT) sequencing has been limited due to th...

medrxiv.org

Join us at #ESCMID to discover how experts are utilising real-time Oxford Nanopore sequencing to deliver actionable insights into outbreak detection, pathogen identification, and AMR profiling faster than traditional methods. nanoporetech.com/about/events...

www.nature.com/collections/...

Top 25 downloaded papers of 2024

The 25 most downloaded papers published in Communications Medicine in 2024

nature.com

www.nature.com/collections/...

Top 25 downloaded papers of 2024

The 25 most downloaded papers published in Communications Medicine in 2024

nature.com

This is the updated metagenomics protocol for respiratory samples search.app/V491AEp3tmB7...