Alessandro Esposito π¨βπ¬π¬π§¬π¨βπ©βπ§πͺπΊπ³οΈβπ
@aesposito1975.bsky.social
#Physicist and cancer #biologist studying how molecular networks encode cell decisions and how mutations hijack cells, leading to #cancer. Centre for Genome Engineering and Maintenance Brunel University of London
A personal reflection on cannabis/THC use and students at Universities. quantitative-biology.org/the-hangover... #university #THC
The hangover you canβt sleep off? A lower starting salary.
University life is an incredible journey β a time of immense learning, growth, new friendships, and yes, a fair bit of navigating newfound freedoms and pressures. Itβs a period where you are β¦
quantitative-biology.org
I am pleased to share a link to the latest paper from the Cook lab. www.biorxiv.org/content/10.6... The DYRK protein kinases, near neighbours to the MAPKs in the CMGC arm of the human kinome, control critical cell fate decisions and are deregulated in disease, much like the MAPKs and CDKs.
biorxiv.org
Confused about Fisher Information and optimisation of Fluorescence Microscopy, #FLIM specifically? I have just completed a tutorial for you hilight-horizon.github.io/HILIGTHer_FL... @hilighthorizon.bsky.social
How many photons do you need to measure a fluorescence lifetime? We are proud to release HILIGTHer, a #FLIM #DigitalTwin designed to simulate most features of time-domain FLIM systems, just announced at #FOM2026 and incredibly well-received. Beta release now available: github.com/HiLIGHT-HORI...
What is Focus on Microscopy for me? A scientific family, friends and amazing innovation. We often see, even 10 years in advance, the techniques that will eventually disrupt biology, biomedical research, and healthcare. Industry and academia, together. #FOM2026 #Microscopy #HILIGHT
Weβre open! Todayβs your chance to get hands on with world-leading science π¬ π§ͺβοΈπ±π #CamFest
I am honoured to be appointed as new Director for @cengem.bsky.social. With massive thanks for Prof Jo Bridger with whom I worked as deputy over the past few years, CHMLS senior leadership for entrusting me with CenGEM and my amazing colleagues for their support.
π Big news! Meet the new leadership team at #CenGEM!π§¬π¬ We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance. #GenomeMaintenance #BrunelUniversity #BioScience
We are excited to announce HILIGHT 2026: FLIM & Photonics, a free two day technical meeting at Brunel University London on 4thβ5th March 2026. The programme will include talks from leading experts, posters, flash talks, and dedicated industry exhibition. Register here: shorturl.at/AwEOv
π FLIM Advent Calendar π This December weβre revealing speakers for HILIGHT 2026: FLIM & Photonics Day 1: Prof Ruslan Dmitriev on using FLIM to track nanoplastics in organoids. Free Event: lnkd.in/eGUXXzNe LinkedIn Event page: lnkd.in/eBTRJRhq HILIGHT website Event page : lnkd.in/ewRw4G4j
π FLIM Advent Calendar π Hereβs the next speaker in our HILIGHT 2026: FLIM & Photonics Day 3: Dr Conor Treacy @c-trass.bsky.social on multiphoton FLIM and DNA signatures in Pancreatic Cancer Spheroids . Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 8: Dr Sylvain Boust, from III-V Lab, on versatile laser diode for 2ph FLIM at 8 Mpx/s in HILIGHT project. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 9: Prof Gail Mcconnell @gailmcconnell.bsky.social on Multiphoton mesoscale imaging with the Mesolens. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 4: Professor Edoardo Charbon on Picosecond Image Sensors: From FLIM to Quantum Imaging. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
exciting developments for fast FLIM... I have great expectations for 2026 :)
πTwo steps forward. One clear direction for the #HILIGHTProject. β‘Sub-nanosecond gating (<1 ns) now fully characterised at #FBK, and the HILIGHT detector has been coupled to a microscope for first photon-count images of Convallaria majalis πΏ. πΈ FLIM images coming next. hilighthorizon.eu/blog/
π FLIM Advent Calendar π The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 5: Dr Falk Schneider @faldalf.bsky.social on Navigating Cross-Excitation Challenges in Multiplexed NADH FLIM. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 7: Dr Gunnar Blume on short-pulse semiconductor lasers for fluorescence lifetime imaging and spectroscopy at FBH. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π The next speaker in our HILIGHT 2026: FLIM & Photonics event line-up. Day 6: Dr Sara Pellegrini on Pixels for FLIM: SPADs in monolithic and 3D stacked technology. Free Event: lnkd.in/eGUXXzNe LinkedIn: lnkd.in/eBTRJRhq HILIGHT: lnkd.in/ewRw4G4j
π FLIM Advent Calendar π Hereβs the next speaker in our HILIGHT 2026: FLIM & Photonics Day 2: Prof Marina Kuimova on measuring cellular viscosity with molecular rotors and FLIM. Free Event: lnkd.in/eGUXXzNe LinkedIn Event page: lnkd.in/eBTRJRhq HILIGHT website Event page : lnkd.in/ewRw4G4j
If you want to know why all biological models are wrong, you will be interested in our latest virtual debate. open.spotify.com/episode/6Usp... #biology #model #science
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph rudolphlab.com/blog/on-narr...
Rudolph BLOG
Pages of the Rudolph laboratory at Brunel University London.
rudolphlab.com
The audio overview of our latest paper is now available on Spotify: open.spotify.com/episode/6ej9... #KRAS #metabolism
EMBO Reports - FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer
open.spotify.com
I use #NotebookLM quite a bit for work. Useful for converting your content (in this case, our latest paper) into different formats. Here a #mindmap of "FOXO1 links #KRAS G12D and G12V alleles to glutamine and nitrogen #metabolism in #colorectalcancer" doi.org/10.1038/s443...
www.embopress.org/doi/full/10.... Congratulations to Dilem Shakir, Michael Batie, Chun-Sui Kwok, Niall Kenneth and @srochaliv.bsky.social on their their lovely study describing NF-ΞΊBβs central role in the hypoxia response - just out in EMBO Reports. A pleasure to collaborate with Team Rocha!!π πΎ π
NF-ΞΊB is a central regulator of hypoxia-induced gene expression | EMBO reports
imageimageHypoxia induces a specific NF-ΞΊB-dependent gene signature across multiple cell systems. NF-ΞΊB is required for over 60% of gene repression occurring in response to hypoxia, controlling oxidat...
embopress.org
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway. www.embopress.org/doi/full/10....
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...
embopress.org
www.embopress.org/doi/full/10.... Congratulations to Suzan Ber and @aesposito1975.bsky.social on their lovely study of KRAS alleles on glutamine and nitrogen metablism and signalling - just out in EMBO Reports. Such a pleasure to collaborate on this fascinating project! π
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...
embopress.org
Another key milestone in the #HILIGHTProject development roadmap π Our first multi-section 905 nm laser purpose-built for #2phFLIM is fabricated! π¬ π§ͺ Next: characterisation at #III-VLab. @csem.ch , #BrunelUniversityLondon, @aesposito1975.bsky.social, #FBK, #VivaScope hilighthorizon.eu/blog/
HILIGHT
EU HORIZON project
hilighthorizon.eu
Happy new academic year for all our students and colleagues at Brunel. #bruneluniversity #success @cengem.bsky.social