Centre for Genome Engineering and Maintainance
@cengem.bsky.social
The Centre for #Genome Engineering and Maintenance nurtures #interdisciplinary research focused on improving the quality of life and increasing #lifespans. 👨🔬🧬 https://tinyurl.com/3wdwkasz Brunel University of London
🚀 Big news! Meet the new leadership team at #CenGEM!🧬🔬 We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance. #GenomeMaintenance #BrunelUniversity #BioScience
cengem.org
When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph rudolphlab.com/blog/on-narr...
Rudolph BLOG
Pages of the Rudolph laboratory at Brunel University London.
rudolphlab.com
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway. www.embopress.org/doi/full/10....
FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer | EMBO reports
imageimageKRAS mutations at codon 12 induce profound metabolic changes in colorectal cancer cells. These oncogenic mutations promote FOXO1-dependent glutamine and nitrogen recycling, uncovering a vuln...
embopress.org
Very exciting few days this week as we attended and presented our work at the 5th Crick International Cancer Conference. Well done Rebecca! @crick.ac.uk @cengem.bsky.social @cancerresearchuk.org
The Authors have found that overexpression of the centriolar protein SAS-6 causes an increase in cell invasion through the activation of the YAP/TAZ pathway @cengem.bsky.social @tanosbarbara.bsky.social www.life-science-alliance.org/content/8/10...
Happy new academic year for all our students and colleagues at Brunel. #bruneluniversity #success @cengem.bsky.social
SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social www.life-science-alliance.org/content/8/10...
Thrilled for the publication of our latest paper on the role of SAS-6 in invasion. This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends! @zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles
Life Science Alliance@lsajournal.org · last yr.SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social www.life-science-alliance.org/content/8/10...
We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology open.spotify.com/episode/3vv8...
E03 - CHRDL2 in Colorectal Cancer [New paper from Lewis Lab]
CenGEM | Centre for Genome Engineering and Maintenance · Episode
open.spotify.com
Centre for Genome Engineering and Maintenance at Brunel University of London Research Showcase at Senate House.
When the work of centre members has an impact on people. News from Dr Victor Hernandez and Axovia Therapeutics. #gentherapy #cengem axoviatherapeutics.com/axovia-thera...
Axovia Therapeutics Presents New Preclinical Data for AXV-101 for the Treatment of Blindness Associated with BBS Mutations at ASGCT - Axovia Therapeutics
London, UK – May 13, 2025 – Axovia Therapeutics Ltd., a biotechnology company developing therapies to address the genetic causes of blindness and obesity, announced the presentation of new preclinical...
axoviatherapeutics.com
#Microscopills Episode 1. A brief refresher about what #FRET is and FRET #microscopy can do. A primer in a conversational podcast format. open.spotify.com/episode/4JoK...
Microscopills E01 - A FRET primer: the basics
Quantitative Biology: Papers and Perspectives · Episode
open.spotify.com
Dear Colleagues, I want to ask you a favour. As you know, I joined Brunel two years ago and I am committed to making Biosciences, @cengem.bsky.social and Brunel University of London grow. Bunel is a very special project for me.
Microsoft Forms
bit.ly
Single nucleic acids probe imaged by #FLIM exemplifies how #fluorescence #lifetimes can reveal physicochemical characteristics of the sample hidden within the mere brightness of the sample. Shared just for fun :) red: high lifetime; blue: low lifetime. Probe: to be announced ;) #livecellimaging
Very humbled and honored to share my story. Thank you @jcellsci.bsky.social and Sara Morais da Silva for the interview! journals.biologists.com/jcs/article/... @cengem.bsky.social
Cell scientist to watch – Barbara Tanos
ABSTRACT. Barbara Tanos is a Senior Lecturer in Biomedical Sciences in the Department of Life Sciences at Brunel University London (UK). Barbara received her undergraduate degree from the University o...
journals.biologists.com
[new review] Zhang Lab. Recent advances and applications of artificial intelligence in 3D bioprinting. Biophys Rev (Melville) http://dlvr.it/TGbPnR
Recent advances and applications of artificial intelligence in 3D bioprinting
3D bioprinting techniques enable the precise deposition of living cells, biomaterials, and biomolecules, emerging as a promising approach for engineering functi
dlvr.it
[New paper] Roberts Lab. 5-aza-2'-deoxycytidine induces #telomere dysfunction in #breast #cancer cells. Biomed Pharmacother. http://dlvr.it/TGZ4HL
Redirecting
dlvr.it
[New review] Tosi Lab. The role of #diet in #cancer: the potential of shaping public #policy and #clinical outcomes in the UK. Genes Nutr http://dlvr.it/TGWz87
The role of diet in cancer: the potential of shaping public policy and clinical outcomes in the UK - Genes & Nutrition
dlvr.it
Scientists have developed an automated tool to study cell growth and division, including hard-to-study, free-floating blood cancer cells.
Cell cycle tracker
Scientists have developed an automated tool to study cell growth and division, including hard-to-study, free-floating blood cancer cells.
buff.ly
[new paper ] Rudolph Lab. Repurposing Proximity-Dependent Protein Labeling (#BioID2) for Protein Interaction Mapping in E. coli. Methods Mol Biol http://dlvr.it/TGTj3D
Repurposing Proximity-Dependent Protein Labeling (BioID2) for Protein Interaction Mapping in E. coli
Methods that identify protein-protein interactions are essential for understanding molecular mechanisms controlling biological systems. Proximity-dependent labeling has proven to be a valuable method for revealing protein-protein interaction networks in living cells....
dlvr.it
[new review] Karteris Lab. The "Road" to Malignant Transformation from #Endometriosis to Endometriosis-Associated #Ovarian #Cancers (EAOCs): An #mTOR-Centred Review. Cancers (Basel) http://dlvr.it/TGSRX0
The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review
dlvr.it
[new paper] Drenos Lab. No Evidence That Vitamin D Levels or Deficiency Are Associated with the Risk of Open-Angle #Glaucoma in Individuals of European Ancestry: A Mendelian Randomisation Analysis. Genes http://dlvr.it/TGSQdz
No Evidence That Vitamin D Levels or Deficiency Are Associated with the Risk of Open-Angle Glaucoma in Individuals of European Ancestry: A Mendelian Randomisation Analysis
dlvr.it
[New #preprint] Sisu Lab. #GENCODE: massively expanding the #lncRNA catalog through capture long-read #RNA sequencing. http://dlvr.it/TGPqVQ
GENCODE: massively expanding the lncRNA catalog through capture long-read RNA sequencing
dlvr.it
[new paper] Sisu lab. GENCODE 2025: reference gene annotation for human and mouse http://dlvr.it/TGNfV3
GENCODE 2025: reference gene annotation for human and mouse
Abstract. GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as n
dlvr.it
[new review paper] Silva Lab. #Breast #cancer risk and prevention in 2024: An overview from the Breast Cancer UK - Breast Cancer Prevention Conference - Cancer Medicine http://dlvr.it/TGMWyN
Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference
Breast Cancer Risk Factors Mechanism and Epidemiology Research. Chemicals such as bisphenols, PFOS and aluminium have extensive research into their mechanism of action in cell lines and animal models...
dlvr.it
Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity https://www.biorxiv.org/content/10.1101/2024.11.20.624298v1
Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity https://www.biorxiv.org/content/10.1101/2024.11.20.624298v1
Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multip
biorxiv.org
Very excited to be co-chairing the British Society of Antimicrobial Chemotheraphy Antibiotic Resistance and Mechanisms conference with @friendlymicrobe.bsky.social Looking forward to 2 days of great talks and networking @kateduncan.bsky.social @craigmaclean.bsky.social @catrinm.bsky.social
Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding https://www.biorxiv.org/content/10.1101/2024.11.21.624660v1
Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding https://www.biorxiv.org/content/10.1101/2024.11.21.624660v1
Epigenetic memory enables the stable propagation of gene expression patterns in response to transien
biorxiv.org